DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sl and Plce1

DIOPT Version :9

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:XP_006527457.1 Gene:Plce1 / 74055 MGIID:1921305 Length:2298 Species:Mus musculus


Alignment Length:1354 Identity:312/1354 - (23%)
Similarity:475/1354 - (35%) Gaps:517/1354 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 GMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLL----------------------WAT------ 56
            |:||..|.|.|:   :|.||:|...|.::...|.                      |:|      
Mouse   998 GLLELTTAVRKI---RRFPDQRQQWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSTRNPSPG 1059

  Fly    57 ------------------VATQTPR------------TDYEGAIQLREI-REIRVGKHSKEFRLF 90
                              ::|...:            ||.|.|.:..:: ||.|....|.     
Mouse  1060 MSAKNAEKPNMQRNNTLGISTTKKKKKMLMRGESGEVTDDEMATRKAKMYRECRSRSGSD----- 1119

  Fly    91 ADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMVKDTLGAPYPLQIDRWLRR 155
            ..|....|.|:..||.:..: .|.|....:|:...:.|...|        :.:|           
Mouse  1120 PQDVNEQEESEANVITNPPN-PLHSRRAYSLTTAGSPNLATG--------MSSP----------- 1164

  Fly   156 EYYQIENVNTHSAKATEQSPAQV------------TIKDFKLFLAGVSCKMTTGKFMEHFTE-DV 207
                |..|::....::.:||:..            .::.|:.|:...| .|:..:|:|.|.. .:
Mouse  1165 ----IRPVSSPVLSSSNKSPSSAWSSSSWHGRIRGGMQGFQSFMVSDS-NMSFVEFVELFKSFSI 1224

  Fly   208 RRKHDLK--FDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRP---------------A 255
            |.:.|||  ||.:|       :|...::..|.....|....|:...::|               .
Mouse  1225 RSRKDLKDIFDIYS-------VPCNRSASESAPLYTNLTIEENTSDLQPDLDLLTRNVSDLGLFI 1282

  Fly   256 ELKQFLETEQRDVS-----------ASEISSAAIASF------IRDF-----------------V 286
            :.||.|...||.:|           .:.|.|.::..|      :.||                 :
Mouse  1283 KSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIFGVGILQLNDFLVNCQGEHCTYDEILSII 1347

  Fly   287 QDVERDV---QEPYLTFPEFVDFLFSKQNDLWNSKYDQV---FMDMNLPLSSYWIASSHNTYLTG 345
            |..|..|   .:..|:|..|..||..|.|  :.||.|:.   ..::.||||.|:|.|||||||||
Mouse  1348 QKFEPSVSMCHQGLLSFEGFARFLMDKDN--FASKNDESRENKKELQLPLSYYYIESSHNTYLTG 1410

  Fly   346 DQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSE 410
            .|...|||.|.|::.|..|||.||||||:|.|.:|.|:||||:|:||.|.:|::.|...||.:|:
Mouse  1411 HQLKGESSVELYSQVLLQGCRSIELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFITSD 1475

  Fly   411 YPVILSIEQNCSLEQQRNMAQALIEVFGDML----LTQPCDRNEQHLPSPYQLRRKIILKHKKLP 471
            .|:|:|||.:|||.|||.||:....|||:.|    |.:....::..||||.|||||::||:|||.
Mouse  1476 LPIIISIENHCSLPQQRKMAEIFKSVFGEKLVAKFLFETDFSDDPMLPSPDQLRRKVLLKNKKLK 1540

  Fly   472 QFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDPVD-KSWNLYQFVLT 535
                                       ||                   :.||| .....:|....
Mouse  1541 ---------------------------AH-------------------QTPVDILKQKAHQLASM 1559

  Fly   536 HQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEGGRKE 600
            ..:.......|.....|.|::|                                          |
Mouse  1560 QAQAFTGGNANPPPASNEEEED------------------------------------------E 1582

  Fly   601 ADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNH--CRIKLKHENGSIKYYLVENFVFD 663
            .|:....|:...|...|                 .:||.:  |..||:.|               
Mouse  1583 EDEYDYDYESLSDDNIL-----------------EDRPENKSCADKLQFE--------------- 1615

  Fly   664 SLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPS 728
                                  ..|.||:..|..|      |::..:.:  :|.:|:|.      
Mouse  1616 ----------------------YNEEVPKRIKKAD------NSSGNKGK--VYDMELGE------ 1644

  Fly   729 VQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQEL 793
                                                       .:|    |.:|.|.|..::.||
Mouse  1645 -------------------------------------------EFY----LPQNKKESRQIAPEL 1662

  Fly   794 LRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRDN 858
                                       |:|.  :.|:|           :.||            
Mouse  1663 ---------------------------SDLV--IYCQA-----------VKFP------------ 1675

  Fly   859 SMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTD---GRTDSIEIFGAVASLFESNDPG 920
                     |:                    ::||..|:.   .|.....|||        |:||
Mouse  1676 ---------GL--------------------STLNSSGSSRGKERKSRKSIFG--------NNPG 1703

  Fly   921 IIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLII 985
            .:      :|....||     |:.:.....:.::.....:|.|:.           :..:|.:| 
Mouse  1704 RM------SPGETAPF-----NRTSGKGSCEGMRHTWEESSPLSP-----------STSLSAII- 1745

  Fly   986 YFRSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPF 1050
               ..|...|      :||..| .|.|:..::.:|..:.:...|:.|.||...|:||||.||:.|
Mouse  1746 ---RTPKCYH------ISSLNE-NAAKRLCRRGSQKLIQHTAYQLLRTYPAATRIDSSNPNPIMF 1800

  Fly  1051 WNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSDS------FNPNNPLCDGLSEV 1109
            |..|.|::||||||.|..:.||.|.|..||.|||:|||..:...|      |:|.....|.|...
Mouse  1801 WLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKSCPMYQKFSPLERDLDNLDPA 1865

  Fly  1110 KVSIRLIAARHLFRGGKSNNPQIVVELIGASFDTGVKYRTK-VNENGFNPVWNESCEFNVRNPQF 1173
            ..|:.:|:.:::.....:.:|.|.|:::|...|: ..:||| ::.|..||:|||...|.|.....
Mouse  1866 IYSLTIISGQNVCPSNSTGSPCIEVDVLGMPLDS-CHFRTKPIHRNTLNPMWNEQFLFRVHFEDL 1929

  Fly  1174 AILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLIN 1227
            ..|||.|.:.:..|.|   ||...||..:::|||.:.|||..:|.||:|||.||
Mouse  1930 VFLRFAVVENNSSAIT---AQRIIPLRALKRGYRHLQLRNLHNEILEISSLFIN 1980

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 33/183 (18%)
PI-PLCc_gamma 323..>470 CDD:176534 78/150 (52%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 11/99 (11%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 12/99 (12%)
SH3_PLCgamma 828..880 CDD:212759 5/51 (10%)
PLCYc 981..1091 CDD:128454 44/109 (40%)
C2_PLC_like 1109..1215 CDD:175974 34/106 (32%)
Plce1XP_006527457.1 PRK12355 <221..>283 CDD:237072
RasGEF 528..826 CDD:382986
EFh_PI-PLCepsilon 1195..1375 CDD:320033 38/187 (20%)
EF-hand motif 1196..1223 CDD:320033 7/27 (26%)
EF-hand motif 1229..1285 CDD:320033 11/62 (18%)
EF-hand motif 1300..1337 CDD:320033 5/36 (14%)
EF-hand motif 1342..1375 CDD:320033 8/32 (25%)
PI-PLCc_epsilon 1388..1829 CDD:176538 176/765 (23%)
C2_PLC_like 1864..1980 CDD:175974 40/119 (34%)
RA1_PLC-epsilon 2003..2110 CDD:340749
RA2_PLC-epsilon 2130..2232 CDD:340478
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

Return to query results.
Submit another query.