Protein Alignment sl and plcb2

DIOPT Version :10

• Sequence 1: NP_476726.2
• Gene: sl / 32601
• FlyBaseID: FBgn0003416
• Length: 1236
• Species: Drosophila melanogaster
• Sequence 2: XP_073784100.1
• Gene: plcb2 / 569376
• ZFINID: ZDB-GENE-080419-1
• Length: 1208
• Species: Danio rerio
• Alignment Length: 1250
• Identity: 269/1250 - (21%)
• Similarity: 400/1250 - (32%)
• Gaps: 563/1250 - (45%)

  Fly    52 LLWATVATQTPRTDYEGAIQLREIREIRVG------KHSKEFRLFADDCQRFESS----KCFVIL 106
            |.|   ..|:..|::   :.:..||:.|.|      ||.|...:|..|   |..|    |...|:
Zfish    47 LYW---VNQSKETEF---LDVATIRDTRAGKYAKMPKHPKVRNIFNMD---FPDSHHLAKTLTIV 102

  Fly   107 HG-NHFKLKSFSVVALSEIEADNWVRGLRYMVKDTLGAPYPLQIDRWLRREYYQIENVNTHSAKA 170
            .| :...|...:..|..|: |..|...:..:..:||.|....|:  :|.:.|.::........|
Zfish   103 TGPDTVNLTYHNFFAAKEV-AQMWADDILAIAYNTLRANSCRQL--YLDKVYVRLTLQTNKDGK- 163

  Fly   171 TEQSPAQVTIKD-FKLFLAG--------VSCKMTTGKFMEHFTEDVRRKHDLKFDDFSRLYQKLL 226
                   :.:|: ||:|.|.        .:..:..|||           ..:|.|.|:....|..
Zfish   164 -------IPVKNIFKMFPADKKRVDAALAAANLPRGKF-----------DTIKTDVFTEAAFKTF 210

  Fly   227 LPN---------GFASVLSGSG------VANFPYSEDQQ----------VVRPAELKQFLETEQR 266
            :.|         .|.|...|.|      .|.| .:|.|:          .:||.::|..:  |:.
Zfish   211 IMNLCPRPEINDIFTSFTKGKGFMTKEMFAKF-LNEKQRDSRLNEELFPPMRPEQVKSLI--EKY 272

  Fly   267 DVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPE-FVDFLFSKQNDLWNSKYDQVFM--DMNL 328
            :.|:|..|.:.|:                     || .:.:|...:..:  .|.|::..  ||..
Zfish   273 EPSSSNASRSQIS---------------------PEGLMFYLMGSETSV--VKLDKLAQSHDMTQ 314

  Fly   329 PLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNG--PDNLPYIFHGHTITSK 391
            .|:.|:|.||||||||..|.:..||.|.|.:.|..||||:|||||.|  ||..|.|.||.|:|::
Zfish   315 TLAHYFIKSSHNTYLTAGQLTGVSSPEMYRQCLLAGCRCLELDCWKGKPPDEEPIITHGFTMTTE 379

  Fly   392 IKFMDVIKTIKDHAFTSSEYPVILSIEQNC-SLEQQRNMAQALIEVFGDMLLTQPCDRNE----Q 451
            |.|.|||:.|.:.||.:|:|||:||.|.:. |::||..||.....:|||.||....|:..    |
Zfish   380 ILFKDVIEAIAESAFKTSKYPVVLSFENHVDSVKQQEKMANYCRTIFGDALLIDLLDKYPLKPGQ 444

  Fly   452 HLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGL 516
            .:|||.:|..||::|:||
Zfish   445 PIPSPSELMGKILIKNKK----------------------------------------------- 462

  Fly   517 LYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSAND 581
                                                        ||:....:
Zfish   463 --------------------------------------------SSAAPSKA------------- 470

  Fly   582 ELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLK 646
                                                                             
Zfish   471 ----------------------------------------------------------------- 470

  Fly   647 HENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQA 711
                                                     ||..:|...|.        |.:.|
Zfish   471 -----------------------------------------EPSKKPAAQEQ--------TSDPA 486

  Fly   712 EQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTR 776
            |        ||    .:.||.:|                                         .
Zfish   487 E--------GS----EATQSTDA-----------------------------------------T 498

  Fly   777 NPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPD 841
            .|...|.:.:.|           .||.|:....|||:
Zfish   499 QPTPNNPEGTDP-----------PAATGEDREEHDDH---------------------------- 524

  Fly   842 ELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEI 906
                                                     |...|:....::|||.|:
Zfish   525 -----------------------------------------DEQDEEKMKNSDEGTAGQ------ 542

  Fly   907 FGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKE 971
                                                :.||||
Zfish   543 ------------------------------------EVTAYE----------------------- 548

  Fly   972 RTARVAKEMSDLIIY--------FRSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRN 1028
                   |||.|:.|        |.:...:...::   :|||.|||.| ....:|...::.|::.
Zfish   549 -------EMSALVNYVQPNKFISFENAAKKNRCFV---ISSFVETKGE-SLIAKNAVDWVEYNKR 602

  Fly  1029 QISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKS 1093
            |:||:||||.|:||||::|.|||:.|.|.:||||||.|..||||.|.|..||:.||:||...|:.
Zfish   603 QLSRIYPKGTRVDSSNYSPQPFWSAGCQFVALNYQTMDFPMQLNMALFEFNGRTGYLLKHDVMRR 667

  Fly  1094 DSFNPNNPLCDGLSEV---KVSIRLIAARHLFRGGKSNNPQIVVELIGASFDTGVKYRTKVNE-- 1153
             |....:|.||.:..:   .::|::.:.:  |...|:....:.|||||...|...|||||::.
Zfish   668 -SDKKFDPFCDRIDTIIASTLTIKIYSGQ--FLSDKAVKTGVEVELIGLPKDPKRKYRTKMSSTA 729

  Fly  1154 NGFNPVWNESCEF---NVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKF 1215
            ||.||.|||. .|   .|..|:.|.||..||:|.    ..||.....||..::.|::.:.||::.
Zfish   730 NGINPDWNEE-PFIFEKVLLPEMAYLRLVVQEEG----GKFIGHRIIPLDALQTGFQHIGLRSES 789

  Fly  1216 SEELELSSLLINIKI 1230
            :..|.|.||.::|::
Zfish   790 NMPLMLPSLFVHIEM 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	26/105 (25%)
		EFh_PI-PLCgamma	152..311	CDD:320031	35/193 (18%)
		EF-hand motif	152..191	CDD:320031	8/47 (17%)
		EF-hand motif	198..226	CDD:320031	6/27 (22%)
		EF-hand motif	230..265	CDD:320031	11/50 (22%)
		EF-hand motif	277..311	CDD:320031	4/34 (12%)
		PI-PLCc_gamma	323..>470	CDD:176534	72/155 (46%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	0/97 (0%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	12/99 (12%)
		SH3_PLCgamma	828..880	CDD:212759	0/51 (0%)
		PLCYc	981..1091	CDD:128454	50/117 (43%)
		C2_PLC_like	1109..1215	CDD:175974	37/113 (33%)
plcb2	XP_073784100.1	None