DRSC/TRiP Functional Genomics Resources

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Protein Alignment sl and plcd3a

DIOPT Version :9

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_001092893.1 Gene:plcd3a / 569040 ZFINID:ZDB-GENE-070620-1 Length:784 Species:Danio rerio


Alignment Length:1261 Identity:271/1261 - (21%)
Similarity:428/1261 - (33%) Gaps:558/1261 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 PL--LGEM-EQTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLLWATVATQTPRTDYEGAIQ 71
            ||  ||.: ::.:.::.:|:.:.|:..::.|.|||..:|  |....:|...:..:.:::.:....
Zfish    25 PLRRLGVLDDEDVLLMLQGSKMMKVRSQRWRKDRRLKLL--EDCVTVWCESSKTSRKSNRQQTFS 87

  Fly    72 LREIREIRVGKHSKEFRLFADDCQRFESSKCF-VILHGNHFKLKSFSVVALSEIEADNWVRGLRY 135
            :.|:..:|.|..|:..|...|   ......|| |:..|..   ||..:...::.||:.||||:|.
Zfish    88 VTEVECVREGCQSECLRRMTD---LVPEKNCFTVVFRGGR---KSLDLCCHTQEEAERWVRGIRT 146

  Fly   136 MVKDTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMT----- 195
            :...........::|.|:|          .:..:|.:....:::..:.|..|..::..:.     
Zfish   147 LKDRVSNMSQKEKLDHWIR----------GYLRRADQNQDGKMSYDEVKHLLQLINIDLNEQYAR 201

  Fly   196 ----------TGKF----MEHFTEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYS 246
                      .|:.    :|.|..::.|:.:|  |...|.|             ||:|.      
Zfish   202 TLFKKCDRSCDGRLDHVEIEEFCREMMRRPEL--DAVFRHY-------------SGNGC------ 245

  Fly   247 EDQQVVRPAELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQ 311
                |:...||:.||..:..|.|.....|......:.|:.|      :..::|...|..::.||:
Zfish   246 ----VLTTLELRDFLGDQGEDASLVHAKSLIQTFELNDWAQ------KNLFMTQNGFTMYMLSKE 300

  Fly   312 NDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGP 376
            ||::|..:..|:.||:.||:.|:|:||||||||.||.:|.||.|.|.|||..||||:|||||:|.
Zfish   301 NDVFNPDHTHVYQDMSKPLAHYYISSSHNTYLTKDQVTSASSTEPYIRALNQGCRCVELDCWDGD 365

  Fly   377 DNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDML 441
            ...|.|:||||:|||:.|.:||:||..:||.:|.||:|||:|.:||:|||..|||.|..:.|..|
Zfish   366 KGEPIIYHGHTLTSKVLFKEVIETIAQYAFKASPYPLILSLENHCSVEQQAIMAQQLQSILGKKL 430

  Fly   442 LTQP-CDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDG 505
            |.:| .|...:.||||.:|:.:|:||.|||       ||:     ||.                 
Zfish   431 LAKPLSDLPLKQLPSPEELKGRILLKGKKL-------NGL-----LGK----------------- 466

  Fly   506 ENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNM 570
                              .:||..:.                    ||.|::             
Zfish   467 ------------------TESWTSFT--------------------NSSDEE------------- 480

  Fly   571 QQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRR 635
                                  .:.||.|                   :||              
Zfish   481 ----------------------SVAGGNK-------------------KES-------------- 490

  Fly   636 NRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQE 700
                                                 :|::.||:                    
Zfish   491 -------------------------------------KKDLARSA-------------------- 498

  Fly   701 WFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFE 765
                                                                             
Zfish   499 ----------------------------------------------------------------- 498

  Fly   766 SLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCK 830
                                                                             
Zfish   499 ----------------------------------------------------------------- 498

  Fly   831 ALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEE 895
                                                                             
Zfish   499 ----------------------------------------------------------------- 498

  Fly   896 GTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIA 960
                                                                             
Zfish   499 ----------------------------------------------------------------- 498

  Fly   961 SQLASERRKKERTARVAKEMSDLIIYFRSVPFREHSWIFQE----MSSFPETKAEKQFFQQNTQL 1021
                        :.:::.|:|||::|.:||||.......|.    ::||.|.:|.| ..:.:.:|
Zfish   499 ------------STKLSPELSDLVVYCQSVPFSGFETANQRPPSVITSFSENEALK-LIKDSGKL 550

  Fly  1022 FLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYIL 1086
            |:..:..|:||:||..|||.||||:|...||.|.||:|||:||..:.|.|||.:|..||:|||:|
Zfish   551 FVRNNSRQLSRIYPSAQRLQSSNFDPQDMWNAGCQMVALNFQTPGEQMDLNQGRFLPNGRCGYVL 615

  Fly  1087 KPSFM---KSDSFNPNN----PLCDGLSEVKVSIRLIAARHL--FRGGKSN---NPQIVVELIGA 1139
            ||.|:   ||| |:|.|    |   |....:::||:|:|:.|  ....|.|   :||:.||:.|.
Zfish   616 KPEFLCDPKSD-FDPENTGGGP---GHIPTQLTIRVISAQQLPKINTDKPNSIVDPQVWVEIHGV 676

  Fly  1140 SFDTGVKYRTKVNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQ 1204
            |.|.......:::.|||||.|:.:..|.::.|:.|::||.|:|.|..::..||.|...|.|.:|.
Zfish   677 SIDKARAKTQRIDNNGFNPRWDCTVSFQLQLPELALVRFMVEDHDHKSKNDFIGQFTLPFTSLRT 741

  Fly  1205 GYRSVILRNKFSEELELSSLLINIKI 1230
            |||.|.|.......|..::|.|::|:
Zfish   742 GYRHVHLLKADGSTLSPATLFIHVKV 767

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 28/125 (22%)
PI-PLCc_gamma 323..>470 CDD:176534 80/147 (54%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 8/97 (8%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 0/99 (0%)
SH3_PLCgamma 828..880 CDD:212759 0/51 (0%)
PLCYc 981..1091 CDD:128454 52/113 (46%)
C2_PLC_like 1109..1215 CDD:175974 39/110 (35%)
plcd3aNP_001092893.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25 271/1261 (21%)
PH_PLC_delta 40..158 CDD:270169 28/125 (22%)
PH 48..145 CDD:278594 26/104 (25%)
Substrate binding. /evidence=ECO:0000250 48..78 8/31 (26%)
EF-hand_7 164..227 CDD:290234 7/72 (10%)
EF-hand_10 178..227 CDD:291454 5/48 (10%)
EF-hand_like 232..312 CDD:286375 24/110 (22%)
PLN02952 236..768 CDD:178538 227/1030 (22%)
PI-PLCc_delta3 312..608 CDD:176567 144/760 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 473..498 10/149 (7%)
C2_PLC_like 640..767 CDD:175974 42/126 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586451
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R928
SonicParanoid 1 1.000 - - X101
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
76.780

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