DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and plch1

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	XP_021323527.1	Gene:	plch1 / 566479	ZFINID:	ZDB-GENE-060503-398	Length:	1795	Species:	Danio rerio

Alignment Length:	1260	Identity:	299/1260 - (23%)
Similarity:	491/1260 - (38%)	Gaps:	462/1260 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MEQTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLL-WATVATQTPRTDYEGAIQLREIREI 78
            :|:.:.:::.||.:.||  |........|..:.|.|..: |     :..|...:..|.:..:.::
Zfish    57 VERCMSVMQSGTQMVKL--KTGSKGLVRLFYLDEHRSCIRW-----RPSRKSEKAKITIDSLYKV 114

  Fly    79 RVGKHSKEFRLFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMV-----K 138
            ..|:.|..|...|:.  .|:.|.||.|.||||  ::|..:|..:..||..||.||||::     :
Zfish   115 TEGRQSDIFHRHAEG--SFDPSCCFTIYHGNH--MESLDLVTSNSEEARTWVTGLRYLMAGISDE 175

  Fly   139 DTLGAPYPLQIDRWLRR----------------EYYQI---ENVNTHSAKATEQSPAQVTIKDFK 184
            |:| |......|:|:::                |.||:   .|||....|..:.
Zfish   176 DSL-AKRQRTHDQWMKQTFEEADKNGDGLLNMEEIYQLLHKMNVNLPRRKVKQM----------- 228

  Fly   185 LFLAGVSCKMTTGKFMEHFTEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQ 249
                          |.|..|:|  ::..|.|::|:..|:.:.|......:|       ..:|:.:
Zfish   229 --------------FQEADTDD--QQGTLTFEEFTVFYKMMSLRRDLFLLL-------MCFSDKK 270

  Fly   250 QVVRPAELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDL 314
            ..:...||..||..||:   .|.::.......|..| :..|.:.|...|....|.:::.|...|:
Zfish   271 DHLTAEELGNFLRVEQK---MSSVTPECCLDIINKF-EVSEENKQNGVLGIEGFTNYMRSPACDV 331

  Fly   315 WNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNL 379
            :|.::.::..||:.|:.:|:|||||||||||||..|.|..:.||..|:.||||:|:|||:|||..
Zfish   332 FNPQHHEINQDMDQPICNYFIASSHNTYLTGDQLLSHSKTDMYAWVLQAGCRCVEVDCWDGPDGE 396

  Fly   380 PYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDML-LT 443
            |.:.||:|:||||.|..||:||..:||.::|:|||||||.:||::||:.:||.|.|:|||.| :.
Zfish   397 PMVQHGYTLTSKITFKSVIETINKYAFVNNEFPVILSIENHCSIQQQKKIAQHLKEIFGDKLDVG 461

  Fly   444 QPCDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENV 508
            :..:::.:.||||..|:.||:||.|:||.:      :|:                     |.|
Zfish   462 EALNKDPKQLPSPNLLKGKILLKGKRLPSY------LSA---------------------DAE-- 497

  Fly   509 RKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQK 573
                 ||                            |:::..:.:..:|||.|.:|.|...:..|.
Zfish   498 -----EG----------------------------EVSDDDSADEIEDDFKLKNSTSNGPSQHQV 529

  Fly   574 QKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRP 638
                    |.|.            ||:.|.|:|:.:               :||
Zfish   530 --------ESHI------------RKKLDSLMKESQ---------------IGD----------- 548

  Fly   639 NHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFH 703
                   |.:..|              :|:     :.:||::               ||..:
Zfish   549 -------KEDTDS--------------FSI-----RALLRAT---------------HEGLQ--- 569

  Fly   704 PNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLV 768
             ...::.::.|:.:.:..||:                  ..:||.|
Zfish   570 -RNLRKNSKDGMKKSQSRSFI------------------SNLKHKR------------------- 596

  Fly   769 SLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALY 833
                                                 ||                :..:.|:::
Zfish   597 -------------------------------------HS----------------KSRLKCQSV- 607

  Fly   834 SYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTD 898
                                                               .|||  ...:|.:.
Zfish   608 ---------------------------------------------------ETED--DSQQEPSG 619

  Fly   899 GRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQL 963
            |               :.|..|
Zfish   620 G---------------QFNRGG------------------------------------------- 626

  Fly   964 ASERRKKERTARVAKEMSDLIIYFRSVPFREHSWIFQEMS-----SFPETKAEKQFFQQNTQLFL 1023
               ||:|  |.::::::|||:::..||..:|   ...|.|     ||.|.:|: .......:.||
Zfish   627 ---RRRK--TIKLSRDLSDLVVFTNSVASQE---CLDEGSPCNVLSFSEARAQ-NLVHHRAERFL 682

  Fly  1024 SYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKP 1088
            ::::.|:||:||...|:|||||||..:||||.|::||||||..:.||||:|||..||..||:|||
Zfish   683 TFNQRQLSRIYPSAYRIDSSNFNPQTYWNVGCQLVALNYQTEGRMMQLNRAKFMVNGGSGYVLKP 747

  Fly  1089 SFMKSDSFNP--NNPLCDGLSEVKVSIRLIAARHLFR--------GGKSNNPQIVVELIGASFDT 1143
            |.|...:|||  :.|| ....:.::.|::|:.:.|.:        .|:..:|.:.||:||...|.
Zfish   748 SLMSKGAFNPLSDEPL-PANPKKQLVIKIISGQQLPKPPDSMLGDRGEIIDPFVEVEIIGLPVDC 811

  Fly  1144 GVKYRTKVNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRS 1208
            ..:....|::|||||||.|:..|.:..|:.|::||.|.|.|.... .|:.|.....:.:..|||.
Zfish   812 CKEQTRVVDDNGFNPVWEETLSFTLHMPEVALVRFLVWDHDPIGR-DFVGQRTIAFSSLMPGYRH 875

  Fly  1209 VILRNKFSEELELSSLLINIKIANV 1233
            |.|     |.:..:|:.::|.:.::
Zfish   876 VYL-----EGMTEASIFVHITVHDI 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	37/130 (28%)
		PI-PLCc_gamma	323..>470	CDD:176534	78/147 (53%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	13/97 (13%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	8/99 (8%)
		SH3_PLCgamma	828..880	CDD:212759	1/51 (2%)
		PLCYc	981..1091	CDD:128454	53/114 (46%)
		C2_PLC_like	1109..1215	CDD:175974	34/113 (30%)
plch1	XP_021323527.1	PH_PLC_eta	64..170	CDD:270170	34/116 (29%)
		EFh_PI-PLCeta1	188..328	CDD:320050	33/177 (19%)
		EF-hand motif	188..217	CDD:320050	4/28 (14%)
		EF-hand motif	224..254	CDD:320050	9/56 (16%)
		EF-hand motif	258..286	CDD:320050	6/34 (18%)
		EF-hand motif	295..328	CDD:320050	7/33 (21%)
		PI-PLCc_GDPD_SF	340..738	CDD:326331	174/761 (23%)
		C2_PLC_like	768..892	CDD:175974	37/129 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750