DRSC/TRiP Functional Genomics Resources

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Protein Alignment sl and plcl1

DIOPT Version :10

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:XP_001921798.4 Gene:plcl1 / 563105 ZFINID:ZDB-GENE-090313-194 Length:1137 Species:Danio rerio


Alignment Length:1295 Identity:261/1295 - (20%)
Similarity:417/1295 - (32%) Gaps:540/1295 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 FSAM-SAPLLGEMEQTIGMLERGTIVTKLYGKQRRPD----RRHLMLIRETRQLLWATVATQTPR 63
            ||:| |...:......:..::.|..:.|:     ||:    .|...|..|...|.|     :..:
Zfish    75 FSSMPSEKKVSSAADCLAFMQGGCELKKV-----RPNSRIYSRFYTLDTELGCLRW-----EPSK 129

  Fly    64 TDYEGA-IQLREIREIRVGKHSKEFRLFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEAD 127
            .|.:.| :.:..|||:|.||.::.| :.............|.|:||:.:  :|..:||||...|:
Zfish   130 KDGDRARLDISAIREVRTGKSTETF-IHNGPLDNLAEEAAFSIIHGDDY--QSLDLVALSADVAN 191

  Fly   128 NWVRGLRYMV-----------------KDTLGAPYPLQIDR-WLRREYYQIENVNTHSAKATEQS 174
            .||.|:||::                 :.::|:    ::.| ||..|:..::. :.|...:.:.:
Zfish   192 IWVTGMRYLLSHPGAIGGGIGGDGGVGEGSIGS----KMRRNWLVAEFALVDE-DGHGIVSEDTA 251

  Fly   175 PAQVTIKDFKLFLAGVSCKMTTG----KFMEHFTEDVRRKHDL----KFDDFSRLYQKLLL-PNG 230
            .|.:             ||:..|    |....|.|..|.|..|    ..::|...|.:|.. |:.
Zfish   252 VATI-------------CKLCPGIKEAKVRLRFKEIQRSKEKLTSHVTLEEFQEAYCELCTRPDV 303

  Fly   231 FASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSASEISSAAIASFIRDFVQDV---ERD 292
            :..::.        .|:|::.:...:|:.|||:||   ..|..::......:|.|....   ||.
Zfish   304 YFLLVQ--------LSKDRECLDAQDLRLFLESEQ---GLSMATTEGCLELLRLFEPSAAGRERG 357

  Fly   293 VQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAY 357
            :    |....|..:|.|.:..|.:.::..|..||.:|||.|:|::|:.:||..||....:.....
Zfish   358 L----LGLDGFARYLQSAECQLLDPEHQNVCQDMKMPLSHYFISASYRSYLLDDQVHGRADLGGL 418

  Fly   358 ARALRMGCRCIELDCWNGPDNLPYI---------------FHGHTITSKIKFMDVIKTIKDHAFT 407
            .|||:.||||:||...:||:..|.:               .|.|.....:.....::.:..:||.
Zfish   419 TRALQAGCRCLELGVTDGPEGEPLLGVDHGAEVKHHHHHHHHHHHHHGSVTLRSALEVVNKYAFL 483

  Fly   408 SSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQ---PCDRNEQ--HLPSPYQLRRKIILKH 467
            :|:||::|.:.|.||..|||.:||.|.:|||..|.|.   |.....:  .||||.||:.|::|..
Zfish   484 TSQYPLLLYLCQRCSPSQQRTLAQHLKKVFGPKLYTPESLPVSLGGRATTLPSPEQLKGKVLLVG 548

  Fly   468 KKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDPVDKSWNLYQF 532
            ||||.                             |.:|       .||                 
Zfish   549 KKLPP-----------------------------EEEG-------SEG----------------- 560

  Fly   533 VLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEGG 597
                       |::|      ||::.|..                              |.|.|.
Zfish   561 -----------EVSE------EDEEIGGG------------------------------GPLAGR 578

  Fly   598 RKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVF 662
            |                       .|..|:..|..                              
Zfish   579 R-----------------------MTIPGEEELGV------------------------------ 590

  Fly   663 DSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRP 727
                                 :::..|.|||                                  
Zfish   591 ---------------------VLVVPPPPQP---------------------------------- 600

  Fly   728 SVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQE 792
                                                                 |.::|.|.:|. 
Zfish   601 -----------------------------------------------------RRLRLRHELSD- 611

  Fly   793 LLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRD 857
                 |...|:         .|:.|:....      ...|.|.:.:.|...|.|.    |.:..|
Zfish   612 -----LVAVAR---------TGSRNFYAHR------ASILPSQQHSPPSTPSTPG----TPLNID 652

  Fly   858 NSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGII 922
            .|.|.:...|                           ||..||                      
Zfish   653 PSYWTLCSLG---------------------------EGEAGR---------------------- 668

  Fly   923 FKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYF 987
                                                    ||||.                    
Zfish   669 ----------------------------------------LASES-------------------- 673

  Fly   988 RSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWN 1052
                              ||.             .:|:.:..::||.|...||||||.||..:|.
Zfish   674 ------------------PEE-------------LVSFTKRNLTRVRPSSVRLDSSNPNPQGYWK 707

  Fly  1053 VGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSD--SFNPNNPLC-DGLSEVKVSIR 1114
            .|.|::|||.||....:.||:.:|..||.|||:|:|:.|:.:  .|:..:..| .|:....:.::
Zfish   708 GGVQLVALNQQTPGAMLDLNRGRFMQNGGCGYVLRPAVMREEVSYFSAQSQGCVPGVPPQTLRVK 772

  Fly  1115 LIAARHLFR----GGKSN--NPQIVVELIGASFD-TGVKYRTKVNENGFNPVWNESCEFNVRNPQ 1172
            :|:|..|.:    |.|..  :|.:|:||.|...| |..:.||.. :|..:|:::|:.||.|..|:
Zfish   773 VISAHSLPKPQGSGAKGEVIDPYVVLELHGVPADCTEQRTRTAA-QNQDDPLFDETFEFQVNMPE 836

  Fly  1173 FAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKIAN 1232
            .|:|||.|.|:|...: .||.|......|::.|||:|.|.....:.|..:||.|:|.|.|
Zfish   837 LALLRFVVLDDDYIGD-DFIGQYTIAFECLQPGYRNVPLLGLAGDPLPHASLFIHIAITN 895

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 34/146 (23%)
EFh_PI-PLCgamma 152..311 CDD:320031 35/170 (21%)
EF-hand motif 152..191 CDD:320031 5/38 (13%)
EF-hand motif 198..226 CDD:320031 8/31 (26%)
EF-hand motif 230..265 CDD:320031 6/34 (18%)
EF-hand motif 277..311 CDD:320031 8/36 (22%)
PI-PLCc_gamma 323..>470 CDD:176534 56/166 (34%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 7/97 (7%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 4/99 (4%)
SH3_PLCgamma 828..880 CDD:212759 10/51 (20%)
PLCYc 981..1091 CDD:128454 32/109 (29%)
C2_PLC_like 1109..1215 CDD:175974 37/112 (33%)
plcl1XP_001921798.4 PH_PLC_eta 94..202 CDD:270170 33/120 (28%)
EFh_PI-PLC 230..372 CDD:333715 35/170 (21%)
EF-hand motif 230..259 CDD:320029 7/42 (17%)
EF-hand motif 266..297 CDD:320029 8/30 (27%)
EF-hand motif 302..330 CDD:320029 6/35 (17%)
EF-hand motif 339..372 CDD:320029 8/36 (22%)
PI-PLCc_GDPD_SF 384..734 CDD:472694 130/775 (17%)
C2_PLC_like 766..894 CDD:175974 42/129 (33%)

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