DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sl and plcd4b

DIOPT Version :9

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:XP_689964.4 Gene:plcd4b / 561475 ZFINID:ZDB-GENE-080512-3 Length:753 Species:Danio rerio


Alignment Length:1245 Identity:272/1245 - (21%)
Similarity:409/1245 - (32%) Gaps:540/1245 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 QTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLL----WATVATQTPRTDYEGAIQLREIRE 77
            |.:..::.|....|:..:..| .:||..|..:.:.:.    ||..:..|        ..:.::..
Zfish    13 QNLEAMKAGMFFRKVKSRMWR-RQRHYKLQDDCKTIAYKSSWAINSYST--------FSISDVEA 68

  Fly    78 IRVGKHSKEFRLFADDCQRFESSKCFVIL----HGNHFKLKSFSVVALSEIEADNWVRGLRYMVK 138
            :|.|..|:.....||:   |...:||.::    .||      ..:||.|..||..|::|:|.:::
Zfish    69 VREGHQSEALLGVADE---FPPDRCFTLVFRGRKGN------LDLVAESAEEAQAWIQGVRGLME 124

  Fly   139 DTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGKFMEHF 203
            :........::|:|          ::...:||......::..|:.|..|..::..|..    ||.
Zfish   125 NMENMDESTKLDQW----------ISDWFSKADRNKDGRINFKEAKKLLKMMNIDMNE----EHA 175

  Fly   204 -----TEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQFLET 263
                 ..|..|...|:..:|...|:.|........:..       .||.|.|::...:|::||..
Zfish   176 CCLFKMADKSRSGTLEDQEFVEFYKMLTERREVLDLFQ-------DYSSDGQILSQCDLEEFLRE 233

  Fly   264 EQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNL 328
            ||.:..    ||...|..:.|..:..|.......::...|:.:|.|.:..::|.:...:|.||:.
Zfish   234 EQLEGE----SSYEHALQLIDRYEPSETARMNHSMSVDGFLMYLTSPEGSIFNPERQGIFQDMSQ 294

  Fly   329 PLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFHGHTITSKIK 393
            .|:.|:|:|||||||..||....||.|||.:||:.||||:|:|||||.:..|.::||||.||||.
Zfish   295 SLAHYYISSSHNTYLMEDQLKGPSSVEAYIQALKRGCRCVEVDCWNGANGEPVVYHGHTFTSKIL 359

  Fly   394 FMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRN-EQHLPSPY 457
            ..|||.||..:||.:||||:|:|||.:||:|||:.|||...|:.||||||...|.. ...||||.
Zfish   360 LKDVITTIASYAFKASEYPLIISIENHCSVEQQKVMAQQFREILGDMLLTSTADTEVSSELPSPE 424

  Fly   458 QLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDP 522
            .|:|||:||.||                :||.|                                
Zfish   425 ALKRKILLKGKK----------------IGHES-------------------------------- 441

  Fly   523 VDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGE 587
                                    ||......|:|                              
Zfish   442 ------------------------ESPTAEVSDED------------------------------ 452

  Fly   588 NWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLKHENGSI 652
                                                                             
Zfish   453 ----------------------------------------------------------------- 452

  Fly   653 KYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYR 717
                                                                    |.||     
Zfish   453 --------------------------------------------------------EAAE----- 456

  Fly   718 LEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRN 782
                                                        ||.||..|             
Zfish   457 --------------------------------------------MNKESSTS------------- 464

  Fly   783 VKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPDELSFPK 847
                                                                             
Zfish   465 ----------------------------------------------------------------- 464

  Fly   848 HAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVAS 912
                                    :.|||                     ||             
Zfish   465 ------------------------ESLPA---------------------DG------------- 471

  Fly   913 LFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVA 977
                                                                     |:....:.
Zfish   472 ---------------------------------------------------------KKSKQNLC 479

  Fly   978 KEMSDLIIYFRSVPFR--EHSWIF---QEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKG 1037
            ||:|| |::.:||.|.  |||.|.   .|||||.|:||.| :.::....|:.::..|:.||||.|
Zfish   480 KELSD-IMFCKSVHFHSFEHSRISAKPYEMSSFSESKARK-YSKEAGSDFVLHNTRQLIRVYPSG 542

  Fly  1038 QRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSDS--FNPNN 1100
            .|.||||:.|:..|::|.|::|||:||....|.||...|..||..||:|||..:::..  |:|..
Zfish   543 MRTDSSNYCPVDMWSMGCQIVALNFQTAGMEMDLNDGLFSQNGCSGYVLKPEILRNRERRFDPEK 607

  Fly  1101 P-LCDGLSEVKVSIRLIAARHLFRGGKSN-----NPQIVVELIGASFDTGVKYRTK-VNENGFNP 1158
            | ..:..:.:..|:::|:.:.|.: .|.|     :|.:.||:.|...|. .|..|| ::.|||||
Zfish   608 PEEHEDYNPLVFSVKVISGQQLPK-LKQNEWSIVDPFVRVEIYGVPLDQ-AKQETKYIDNNGFNP 670

  Fly  1159 VWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSS 1223
            .||||.:|.|..|:.|::||.|:|.|..:...||.|...||:||:.|||.|.|.:|....:..||
Zfish   671 YWNESVQFTVHTPELALVRFVVEDHDKASRNDFIGQYTLPLSCIQPGYRHVHLLSKDGTSIRPSS 735

  Fly  1224 LLINIKIANV 1233
            :.::|||..:
Zfish   736 IFVHIKITEL 745

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 27/132 (20%)
PI-PLCc_gamma 323..>470 CDD:176534 83/147 (56%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 0/97 (0%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 8/99 (8%)
SH3_PLCgamma 828..880 CDD:212759 3/51 (6%)
PLCYc 981..1091 CDD:128454 51/114 (45%)
C2_PLC_like 1109..1215 CDD:175974 43/111 (39%)
plcd4bXP_689964.4 PH-like 18..130 CDD:302622 27/129 (21%)
PH 18..124 CDD:278594 27/123 (22%)
EF-hand_5 139..163 CDD:289945 4/23 (17%)
EF-hand_7 143..199 CDD:290234 12/59 (20%)
EF-hand_10 153..202 CDD:291454 11/52 (21%)
PLN02228 207..738 CDD:177873 225/1010 (22%)
EF-hand_like 207..289 CDD:286375 18/92 (20%)
PI-PLCc_delta 289..584 CDD:176535 151/761 (20%)
C2_PLC_like 616..743 CDD:175974 48/128 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586441
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R928
SonicParanoid 1 1.000 - - X101
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.880

Return to query results.
Submit another query.