Protein Alignment sl and plcd4b

DIOPT Version :10

• Sequence 1: NP_476726.2
• Gene: sl / 32601
• FlyBaseID: FBgn0003416
• Length: 1236
• Species: Drosophila melanogaster
• Sequence 2: XP_689964.4
• Gene: plcd4b / 561475
• ZFINID: ZDB-GENE-080512-3
• Length: 753
• Species: Danio rerio
• Alignment Length: 1245
• Identity: 272/1245 - (21%)
• Similarity: 409/1245 - (32%)
• Gaps: 540/1245 - (43%)

  Fly    17 QTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLL----WATVATQTPRTDYEGAIQLREIRE 77
            |.:..::.|....|:..:..| .:||..|..:.:.:.    ||..:..|        ..:.::..
Zfish    13 QNLEAMKAGMFFRKVKSRMWR-RQRHYKLQDDCKTIAYKSSWAINSYST--------FSISDVEA 68

  Fly    78 IRVGKHSKEFRLFADDCQRFESSKCFVIL----HGNHFKLKSFSVVALSEIEADNWVRGLRYMVK 138
            :|.|..|:.....||:   |...:||.::    .||      ..:||.|..||..|::|:|.:::
Zfish    69 VREGHQSEALLGVADE---FPPDRCFTLVFRGRKGN------LDLVAESAEEAQAWIQGVRGLME 124

  Fly   139 DTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGKFMEHF 203
            :........::|:|          ::...:||......::..|:.|..|..::..|..    ||.
Zfish   125 NMENMDESTKLDQW----------ISDWFSKADRNKDGRINFKEAKKLLKMMNIDMNE----EHA 175

  Fly   204 -----TEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQFLET 263
                 ..|..|...|:..:|...|:.|........:..       .||.|.|::...:|::||..
Zfish   176 CCLFKMADKSRSGTLEDQEFVEFYKMLTERREVLDLFQ-------DYSSDGQILSQCDLEEFLRE 233

  Fly   264 EQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNL 328
            ||.:..    ||...|..:.|..:..|.......::...|:.:|.|.:..::|.:...:|.||:.
Zfish   234 EQLEGE----SSYEHALQLIDRYEPSETARMNHSMSVDGFLMYLTSPEGSIFNPERQGIFQDMSQ 294

  Fly   329 PLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFHGHTITSKIK 393
            .|:.|:|:|||||||..||....||.|||.:||:.||||:|:|||||.:..|.::||||.||||.
Zfish   295 SLAHYYISSSHNTYLMEDQLKGPSSVEAYIQALKRGCRCVEVDCWNGANGEPVVYHGHTFTSKIL 359

  Fly   394 FMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRN-EQHLPSPY 457
            ..|||.||..:||.:||||:|:|||.:||:|||:.|||...|:.||||||...|.. ...||||.
Zfish   360 LKDVITTIASYAFKASEYPLIISIENHCSVEQQKVMAQQFREILGDMLLTSTADTEVSSELPSPE 424

  Fly   458 QLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDP 522
            .|:|||:||.||                :||.|
Zfish   425 ALKRKILLKGKK----------------IGHES-------------------------------- 441

  Fly   523 VDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGE 587
                                    ||......|:|
Zfish   442 ------------------------ESPTAEVSDED------------------------------ 452

  Fly   588 NWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLKHENGSI 652
                                                                             
Zfish   453 ----------------------------------------------------------------- 452

  Fly   653 KYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYR 717
                                                                    |.||
Zfish   453 --------------------------------------------------------EAAE----- 456

  Fly   718 LEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRN 782
                                                        ||.||..|
Zfish   457 --------------------------------------------MNKESSTS------------- 464

  Fly   783 VKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPDELSFPK 847
                                                                             
Zfish   465 ----------------------------------------------------------------- 464

  Fly   848 HAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVAS 912
                                    :.|||                     ||
Zfish   465 ------------------------ESLPA---------------------DG------------- 471

  Fly   913 LFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVA 977
                                                                     |:....:.
Zfish   472 ---------------------------------------------------------KKSKQNLC 479

  Fly   978 KEMSDLIIYFRSVPFR--EHSWIF---QEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKG 1037
            ||:|| |::.:||.|.  |||.|.   .|||||.|:||.| :.::....|:.::..|:.||||.|
Zfish   480 KELSD-IMFCKSVHFHSFEHSRISAKPYEMSSFSESKARK-YSKEAGSDFVLHNTRQLIRVYPSG 542

  Fly  1038 QRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSDS--FNPNN 1100
            .|.||||:.|:..|::|.|::|||:||....|.||...|..||..||:|||..:::..  |:|..
Zfish   543 MRTDSSNYCPVDMWSMGCQIVALNFQTAGMEMDLNDGLFSQNGCSGYVLKPEILRNRERRFDPEK 607

  Fly  1101 P-LCDGLSEVKVSIRLIAARHLFRGGKSN-----NPQIVVELIGASFDTGVKYRTK-VNENGFNP 1158
            | ..:..:.:..|:::|:.:.|.: .|.|     :|.:.||:.|...|. .|..|| ::.|||||
Zfish   608 PEEHEDYNPLVFSVKVISGQQLPK-LKQNEWSIVDPFVRVEIYGVPLDQ-AKQETKYIDNNGFNP 670

  Fly  1159 VWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSS 1223
            .||||.:|.|..|:.|::||.|:|.|..:...||.|...||:||:.|||.|.|.:|....:..||
Zfish   671 YWNESVQFTVHTPELALVRFVVEDHDKASRNDFIGQYTLPLSCIQPGYRHVHLLSKDGTSIRPSS 735

  Fly  1224 LLINIKIANV 1233
            :.::|||..:
Zfish   736 IFVHIKITEL 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	27/132 (20%)
		EFh_PI-PLCgamma	152..311	CDD:320031	32/163 (20%)
		EF-hand motif	152..191	CDD:320031	6/38 (16%)
		EF-hand motif	198..226	CDD:320031	7/32 (22%)
		EF-hand motif	230..265	CDD:320031	7/34 (21%)
		EF-hand motif	277..311	CDD:320031	6/33 (18%)
		PI-PLCc_gamma	323..>470	CDD:176534	83/147 (56%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	0/97 (0%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	8/99 (8%)
		SH3_PLCgamma	828..880	CDD:212759	3/51 (6%)
		PLCYc	981..1091	CDD:128454	51/114 (45%)
		C2_PLC_like	1109..1215	CDD:175974	43/111 (39%)
plcd4b	XP_689964.4	PH-like	18..130	CDD:473070	27/129 (21%)
		EF-hand_5	139..163	CDD:433035	4/23 (17%)
		EF-hand_10	153..202	CDD:405477	11/52 (21%)
		PLN02228	207..738	CDD:177873	225/1010 (22%)
		PI-PLCc_delta	289..584	CDD:176535	151/761 (20%)