Protein Alignment sl and plch2b

DIOPT Version :10

• Sequence 1: NP_476726.2
• Gene: sl / 32601
• FlyBaseID: FBgn0003416
• Length: 1236
• Species: Drosophila melanogaster
• Sequence 2: XP_068080446.1
• Gene: plch2b / 560919
• ZFINID: ZDB-GENE-101112-1
• Length: 1260
• Species: Danio rerio
• Alignment Length: 1263
• Identity: 290/1263 - (22%)
• Similarity: 476/1263 - (37%)
• Gaps: 484/1263 - (38%)

  Fly     5 SAMSAP--LLGE-MEQTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLL-WATVATQTPRTD 65
            |.:::|  .:|: :|:.:..::.|:.:.||.||.:...|  |..:.|.:..: |      .|...
Zfish    66 SIVASPKWRMGQIVERCMCNMQAGSQMIKLRGKSKALVR--LFYLDEHKSCIRW------RPSRK 122

  Fly    66 YEGA-IQLREIREIRVGKHSKEFRLFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNW 129
            :|.| |.:..|.|:..|..::.||.||::  .|:.:.||.|.||:|  ::|..:|:.:..||..|
Zfish   123 HERAKITIDSIHEVCEGMRTEVFRRFANN--NFDPNCCFSIYHGDH--VESLDLVSTNGEEARTW 183

  Fly   130 VRGLRYMV-----KDTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAG 189
            :.||:|::     :|:| |......|:|||:.:          ::|.:.....::|.:....|..
Zfish   184 ITGLKYLLAGISDEDSL-AKRQRTRDQWLRQTF----------SEADKNGDGNLSIGEVLQLLHK 237

  Fly   190 VSCKMTTGKFMEHFTE-DV-RRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVV 252
            ::..:...|..|.|.| |. ..:..|.|::|...| ||:.......:|..|      ||..::.:
Zfish   238 LNVNLPKQKVREMFQEADTDENQGSLTFEEFCTFY-KLISTRRDLYLLMIS------YSNHKEHL 295

  Fly   253 RPAELKQFLETEQRDVSAS-EISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWN 316
            ...:|::|||:||:.|:.: |.....|..|     :...::.....|....|.:::.|...|::|
Zfish   296 DLNDLQRFLESEQKMVNVTKEYCKMIINQF-----EPCSQNQSHVVLGIDGFTNYMRSPAGDIFN 355

  Fly   317 SKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPY 381
            .::.||..||..||::|:|||||||||||||..|:|..:.||..|:|||||:|:|||:|||..|.
Zfish   356 PEHYQVNQDMTQPLTNYYIASSHNTYLTGDQLLSQSRVDMYAYVLQMGCRCVEVDCWDGPDGEPI 420

  Fly   382 IFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPC 446
            :.||:|:||||.|.||::||..:||..:::|||||||.:|::.||:.|||.|:||..|.:.....
Zfish   421 VHHGYTLTSKILFKDVVETINKYAFAKTQFPVILSIENHCTVPQQKKMAQYLMEVLQDKVDLSNI 485

  Fly   447 DRNE-QHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRK 510
            :.|| :.||||..|:.||::|.||||                           |:.:.|.:
Zfish   486 NTNESRRLPSPEDLKGKILVKGKKLP---------------------------ANIDADAD---- 519

  Fly   511 VFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQK 575
               ||                            ::::..:|..::::     ...||.:..:...
Zfish   520 ---EG----------------------------DVSDEDSGEEDEEE-----ELQLNGDTTEGAP 548

  Fly   576 DTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNH 640
            ::::.||         .|....||                        |:|.:     ||.:...
Zfish   549 ESASADE---------SKKRSRRK------------------------FMGSF-----RRKKKKQ 575

  Fly   641 CRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPN 705
            .::|                                          |:|:
Zfish   576 VKVK------------------------------------------KKPI--------------- 583

  Fly   706 TTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSL 770
                                                                             
Zfish   584 ----------------------------------------------------------------- 583

  Fly   771 INYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSY 835
                                                                             
Zfish   584 ----------------------------------------------------------------- 583

  Fly   836 KANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGR 900
                                                         |.||.||
Zfish   584 ---------------------------------------------VSDSDTE------------- 590

  Fly   901 TDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLAS 965
                      ..:..:||..:|
Zfish   591 ----------PEITSTNDKQVI------------------------------------------- 602

  Fly   966 ERRKKERTARVAKEMSDLIIYFRSVPFREH---------SWIFQEMSSFPETKAEKQFFQQNTQL 1021
            ...|:.:|.|:::.:|||:.|.:||  |.|         ||   ::||..|: ...|..|.....
Zfish   603 NYGKRRKTMRLSRALSDLVKYTKSV--RVHDIETQAYMSSW---QVSSLNES-ITNQILQLKPAQ 661

  Fly  1022 FLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYIL 1086
            .:.:::.|:.||||...|:|||||||.||||.|..::||||||..:.:|||:|||..||.|||:|
Zfish   662 LVRFNQRQLLRVYPSNYRVDSSNFNPQPFWNAGCHLVALNYQTEGRMLQLNRAKFAANGNCGYVL 726

  Fly  1087 KPSFMKSDSFNP--NNPLCDGLSEVKVSIRLIAARHLFR--------GGKSNNPQIVVELIGASF 1141
            ||..|...:|||  .:|| .|..:.::.:::|:.:.|.:        .|:..:|.:.||:||...
Zfish   727 KPKCMCKGAFNPVLEDPL-PGHRKSQLVLKIISGQQLPKPKDSMLGDRGEIIDPFVEVEIIGLPI 790

  Fly  1142 DTGVKYRTKVNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGY 1206
            |...:....|::|||||.|.|:..|.:..||.|::||.|.|.|.... .||.|.......:..||
Zfish   791 DCNKQQTRVVDDNGFNPTWEETLVFTLHMPQIALVRFMVWDHDPIGR-DFIGQRTISFKSMMPGY 854

  Fly  1207 RSVILRNKFSEELELSSLLINIKIANVT 1234
            |.|.|     |.:|.:|:.:::.:.::|
Zfish   855 RHVYL-----EGMEEASIFVHVAVNDIT 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	38/131 (29%)
		EFh_PI-PLCgamma	152..311	CDD:320031	34/161 (21%)
		EF-hand motif	152..191	CDD:320031	6/38 (16%)
		EF-hand motif	198..226	CDD:320031	10/29 (34%)
		EF-hand motif	230..265	CDD:320031	8/34 (24%)
		EF-hand motif	277..311	CDD:320031	5/33 (15%)
		PI-PLCc_gamma	323..>470	CDD:176534	78/147 (53%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	8/97 (8%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	0/99 (0%)
		SH3_PLCgamma	828..880	CDD:212759	0/51 (0%)
		PLCYc	981..1091	CDD:128454	53/118 (45%)
		C2_PLC_like	1109..1215	CDD:175974	34/113 (30%)
plch2b	XP_068080446.1	PH_PLC_eta	86..192	CDD:270170	35/117 (30%)
		EFh_PI-PLC	210..350	CDD:333715	34/161 (21%)
		EF-hand motif	210..239	CDD:320029	6/38 (16%)
		EF-hand motif	246..275	CDD:320029	10/29 (34%)
		EF-hand motif	280..308	CDD:320029	8/33 (24%)
		EF-hand motif	317..350	CDD:320029	5/37 (14%)
		PI-PLCc_GDPD_SF	362..719	CDD:472694	156/765 (20%)
		C2_PLC_like	749..873	CDD:175974	37/129 (29%)