DRSC/TRiP Functional Genomics Resources

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Protein Alignment sl and PLCG2

DIOPT Version :10

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_002652.2 Gene:PLCG2 / 5336 HGNCID:9066 Length:1265 Species:Homo sapiens


Alignment Length:1265 Identity:478/1265 - (37%)
Similarity:722/1265 - (57%) Gaps:148/1265 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 EMEQTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLLWATVATQTPRTDYEGAIQLREIREI 78
            |..|....||.||::|....::..|:||.:.:|.||||:.|:..|.:     .||.:.:.||:||
Human    14 EKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK-----IEGFLDIMEIKEI 73

  Fly    79 RVGKHSKEF-RLFA----DDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMVK 138
            |.||:||:| |..|    :||       ||.||:|..|.|.:.|:.|.|:.:|.||:.||:.:.:
Human    74 RPGKNSKDFERAKAVRQKEDC-------CFTILYGTQFVLSTLSLAADSKEDAVNWLSGLKILHQ 131

  Fly   139 DTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGKFM-EH 202
            :.:.|..|..|:.|||::.|.::....:|          :::::.|..|..::.|:::.||: :.
Human   132 EAMNASTPTIIESWLRKQIYSVDQTRRNS----------ISLRELKTILPLINFKVSSAKFLKDK 186

  Fly   203 FTEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVV------RP------- 254
            |.|....|.:|.|:.|...|:||:.... .|:|.       .:.:|..|.      ||       
Human   187 FVEIGAHKDELSFEQFHLFYKKLMFEQQ-KSILD-------EFKKDSSVFILGNTDRPDASAVYL 243

  Fly   255 AELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKY 319
            .:.::||..||::..|.:::.  :...:..|:.|..|:..||:|...||:.:|||::|.:|:.||
Human   244 HDFQRFLIHEQQEHWAQDLNK--VRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKY 306

  Fly   320 DQVFM-DMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIF 383
            |.|.| |||.|||.|||:|||||||||||..||||.|||.|.|||||||||||||:|||..|.|:
Human   307 DAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIY 371

  Fly   384 HGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDR 448
            ||.|.|:||||.||::.||||||.:|.:|||||||::||:||||:||:|..|||||:|||:|.:.
Human   372 HGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEA 436

  Fly   449 NEQHLPSPYQLRRKIILKHKKL-PQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVF 512
            :...||||.|||.|||:||||| |:.|...|                       ..|.::..|  
Human   437 SADQLPSPSQLREKIIIKHKKLGPRGDVDVN-----------------------MEDKKDEHK-- 476

  Fly   513 KEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDT 577
            ::|.||..|.:|:.|..:...:...:|.:|.:|.::                     |:::....
Human   477 QQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQT---------------------MEEEVPQD 520

  Fly   578 SANDELHFGENWFHGKLEGGRKEADDLLKKY-KHFG--DGTFLVRESATFVGDYSLSFWRRNRPN 639
            ....||||||.|||.|:| .|..|:.||::| ...|  |||||||||.||..||:|||||..|..
Human   521 IPPTELHFGEKWFHKKVE-KRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQ 584

  Fly   640 HCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHP 704
            ||||:...|.|::||||.:|..|.|:|:||.:||:..||.:||.:.|.:|||.|..||.:.|::.
Human   585 HCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYD 649

  Fly   705 NTTKEQAEQGLYRL-EIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDT-MNFESL 767
            :.::.:||..|.|: ..|:||:|.. :..:::.|:|....|:|||||.::||.:.:.| ..||||
Human   650 SLSRGEAEDMLMRIPRDGAFLIRKR-EGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESL 713

  Fly   768 VSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNG----ASNYMG-SNLEENV 827
            |.|::||.::.|||.::|.:||:.|||.:...|         .|.|.    :..|:. |.:..::
Human   714 VELVSYYEKHSLYRKMRLRYPVTPELLERYNME---------RDINSLYDVSRMYVDPSEINPSM 769

  Fly   828 ---TCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDY 889
               |.||||.|||.:.|||||.:.|:|.||.::...||.||||..|:::.|:|||:  |.:|.|:
Human   770 PQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVE--DISTADF 832

  Fly   890 NSLNEEGTD---------GRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQN--PFVIGFDNQ 943
            ..|.::..:         |..| :..:..|.:....|....:|.|:   |..|.  |.....|..
Human   833 EELEKQIIEDNPLGSLCRGILD-LNTYNVVKAPQGKNQKSFVFILE---PKQQGDPPVEFATDRV 893

  Fly   944 ETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFREHSW---IFQEMSSF 1005
            |..:||.::|:|.........:..:..|:...:|.|:|||::|.:.....:.:.   .|:|:.||
Human   894 EELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSF 958

  Fly  1006 PETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQ 1070
            .||||:....|:...| |.|::..::||||||||:||||::|...|..||||:|||:||.||.||
Human   959 VETKADSIIRQKPVDL-LKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQ 1022

  Fly  1071 LNQAKFRNNGQCGYILKPSFMKSDSFNPNNPLCDGLSEVKVSIRLIAARHLFRGGKS-NNPQIVV 1134
            :|.|.|..||:.||:|:|..|:::.::|..|.......:.::::::.||||.:.|:| ..|.:.|
Human  1023 MNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEV 1087

  Fly  1135 ELIGASFDTGVKYRTKVNENGFNPVW---NESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQAC 1196
            |:.||.:|......|.||:||.:|:|   .|...|.:.:|..|.|||.|.:||||::.:|:|.|.
Human  1088 EICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHAT 1152

  Fly  1197 YPLTCIRQGYRSVILRNKFSEELELSSLLI 1226
            ||:..::.|:|||.|:|.:||::||:|||:
Human  1153 YPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 47/129 (36%)
EFh_PI-PLCgamma 152..311 CDD:320031 41/172 (24%)
EF-hand motif 152..191 CDD:320031 7/38 (18%)
EF-hand motif 198..226 CDD:320031 10/28 (36%)
EF-hand motif 230..265 CDD:320031 8/47 (17%)
EF-hand motif 277..311 CDD:320031 11/33 (33%)
PI-PLCc_gamma 323..>470 CDD:176534 102/147 (69%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 54/100 (54%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 39/101 (39%)
SH3_PLCgamma 828..880 CDD:212759 27/51 (53%)
PLCYc 981..1091 CDD:128454 52/112 (46%)
C2_PLC_like 1109..1215 CDD:175974 42/109 (39%)
PLCG2NP_002652.2 PH_PLC_gamma 22..140 CDD:270168 47/129 (36%)
EFh_PI-PLCgamma2 145..298 CDD:320045 41/172 (24%)
PI-PLCc_gamma 311..>458 CDD:176534 102/146 (70%)
PH-like 475..>510 CDD:473070 9/36 (25%)
SH2_N-SH2_PLC_gamma_like 527..627 CDD:199829 54/100 (54%)
SH2_C-SH2_PLC_gamma_like 641..744 CDD:198186 39/103 (38%)
SH3_PLCgamma2 773..827 CDD:212902 28/55 (51%)
PHsplit_PLC_gamma <840..910 CDD:270054 15/73 (21%)
PI-PLCc_GDPD_SF <926..1031 CDD:472694 48/105 (46%)
C2_PLC_like 1061..1187 CDD:175974 49/122 (40%)

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