DRSC/TRiP Functional Genomics Resources

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Protein Alignment sl and PLCG1

DIOPT Version :9

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:XP_005260495.1 Gene:PLCG1 / 5335 HGNCID:9065 Length:1330 Species:Homo sapiens


Alignment Length:1323 Identity:527/1323 - (39%)
Similarity:760/1323 - (57%) Gaps:189/1323 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 APLLGEMEQTIGMLERGTIVTKLYGKQ-RRPDRRHLMLIRETRQLLWATVATQTPRTDYEGAIQL 72
            ||...|:......||.||::|..|.|: :||:|:...:..||||:.|:..|.:     .||||.:
Human    16 APSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADK-----IEGAIDI 75

  Fly    73 REIREIRVGKHSKEFRLFADD-CQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYM 136
            |||:|||.||.|::|..:.:| ..|.:.|.|||||:|..|:||:.|:.|.||.|.:.|::||.::
Human    76 REIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWL 140

  Fly   137 VKDTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGKFM- 200
            ::|||.||.||||:||||:::|.::          .....:::.||.|..|:.|:.::...:|: 
Human   141 MEDTLQAPTPLQIERWLRKQFYSVD----------RNREDRISAKDLKNMLSQVNYRVPNMRFLR 195

  Fly   201 EHFTEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQV---VRP-------A 255
            |..|:..:|..|:.:..|::||:.|:        .|.....:.|:.|...:   .||       .
Human   196 ERLTDLEQRSGDITYGQFAQLYRSLM--------YSAQKTMDLPFLEASTLRAGERPELCRVSLP 252

  Fly   256 ELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKYD 320
            |.:|||...|.::.|  :....:..|:..|::|..|:::|||....|||.|||||:|.:|||:.|
Human   253 EFQQFLLDYQGELWA--VDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLD 315

  Fly   321 QVFMD-MNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFH 384
            .|..| ||.|||.|||:|||||||||||||||||.|||||.|||||||||||||:|||.:|.|:|
Human   316 AVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYH 380

  Fly   385 GHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRN 449
            |||:|:||||.||:.|||:|||.:||||||||||.:||:.|||||||...:|.||.|||:|.:.:
Human   381 GHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEIS 445

  Fly   450 EQHLPSPYQLRRKIILKHKKLPQ---FDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKV 511
            ...||||.||:|||::|||||.:   ::::...:                  .:.|||   :...
Human   446 ADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSM------------------MYSEND---ISNS 489

  Fly   512 FKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKD 576
            .|.|:||.:|||:..|..:.||||..::.||.| ..|..||.::::                .|:
Human   490 IKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEE-TSSDQGNEDEEE----------------PKE 537

  Fly   577 TSANDELHFGENWFHGKL---EGGRKEADDLLKKY---KHFGDGTFLVRESATFVGDYSLSFWRR 635
            .|::.|||..|.||||||   ..||..|:.||.:|   ....||:||||||.||||||:|||||.
Human   538 VSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRN 602

  Fly   636 NRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQE 700
            .:..||||..:.:.|:.|::|.:|.||||||.||.:|::..||.:||.:.|.|||||...||.:|
Human   603 GKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKE 667

  Fly   701 WFHPNTTKEQAEQGLYRL-EIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNF 764
            |:|.:.|:.|||..|.|: ..|:||||...:. |::.|||....||||||:.|||:...:....|
Human   668 WYHASLTRAQAEHMLMRVPRDGAFLVRKRNEP-NSYAISFRAEGKIKHCRVQQEGQTVMLGNSEF 731

  Fly   765 ESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTC 829
            :|||.||:||.::||||.:||.:|:::|.|.:  ...|:.|:...::......|:.:|......|
Human   732 DSLVDLISYYEKHPLYRKMKLRYPINEEALEK--IGTAEPDYGALYEGRNPGFYVEANPMPTFKC 794

  Fly   830 --KALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVK------VIDSTT 886
              |||:.|||.:.|||:|.|.|||.||::....||.|||||..:...|:|||:      .::...
Human   795 AVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPER 859

  Fly   887 E--DYNS------------------LNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPT 931
            |  |.||                  :..||.:.|                     :|...|...:
Human   860 EHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNR---------------------LFVFSISMAS 903

  Fly   932 MQN-PFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFREH 995
            :.: ...:..|:||...:|:|.|:|.|..|....:|.:..||..::|.|:|:|::|.|.|||.|.
Human   904 VAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEE 968

  Fly   996 S-----WIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGS 1055
            .     ..:::|||||||||||...:...:.||.|:|.|:||:|||||||||||::|:|.|..||
Human   969 KIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGS 1033

  Fly  1056 QMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSDSFNP-NNPLCDGLSEVKVSIRLIAAR 1119
            |::|||:||.||.||:|||.|.....|||:|:||.|:.::|:| :.....||....:||.::.||
Human  1034 QLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGAR 1098

  Fly  1120 HLFRGGKS-NNPQIVVELIGASFDTGVKYRTK--------------------------------- 1150
            ||.:.|:. ..|.:.:|:.||.:|: .|.:|:                                 
Human  1099 HLPKNGRGIVCPFVEIEVAGAEYDS-TKQKTEFVGQSVFPVILLILLGHCKPLPTSHPILSHGDL 1162

  Fly  1151 -------VNENGFNPVW-NESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYR 1207
                   ..:||.|||| .:...|.:.||:||.|||.|.:||||::.:|:|||.:|:..::.|||
Human  1163 KPFVVAFTVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYR 1227

  Fly  1208 SVILRNKFSEELELSSLLINIKI 1230
            :|.|:|.:||:|||:||||.|.|
Human  1228 AVPLKNNYSEDLELASLLIKIDI 1250

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 55/126 (44%)
PI-PLCc_gamma 323..>470 CDD:176534 104/147 (71%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 52/103 (50%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 46/100 (46%)
SH3_PLCgamma 828..880 CDD:212759 27/53 (51%)
PLCYc 981..1091 CDD:128454 62/114 (54%)
C2_PLC_like 1109..1215 CDD:175974 44/147 (30%)
PLCG1XP_005260495.1 PH_PLC_gamma 29..151 CDD:270168 55/126 (44%)
PH <71..142 CDD:278594 33/70 (47%)
PI-PLCc_gamma 319..>466 CDD:176534 104/146 (71%)
PH-like 489..>523 CDD:302622 15/34 (44%)
SH2_N-SH2_PLC_gamma_like 545..649 CDD:199829 52/103 (50%)
SH2_C-SH2_PLC_gamma_like 663..765 CDD:198186 46/104 (44%)
SH3_PLCgamma1 791..850 CDD:212903 28/58 (48%)
PHsplit_PLC_gamma <864..933 CDD:270054 15/89 (17%)
PLCYc 954..1069 CDD:128454 62/114 (54%)
C2_PLC_like 1087..1250 CDD:175974 54/163 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151865
Domainoid 1 1.000 225 1.000 Domainoid score I2539
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1997
Inparanoid 1 1.050 921 1.000 Inparanoid score I355
Isobase 1 0.950 - 0 Normalized mean entropy S3205
OMA 1 1.010 - - QHG45872
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 1 1.000 - - FOG0003159
OrthoInspector 1 1.000 - - otm41507
orthoMCL 1 0.900 - - OOG6_104615
Panther 1 1.100 - - LDO PTHR10336
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R928
SonicParanoid 1 1.000 - - X101
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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