DRSC/TRiP Functional Genomics Resources

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Protein Alignment sl and PLCL1

DIOPT Version :9

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_006217.3 Gene:PLCL1 / 5334 HGNCID:9063 Length:1095 Species:Homo sapiens


Alignment Length:1279 Identity:258/1279 - (20%)
Similarity:418/1279 - (32%) Gaps:575/1279 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 FSAM-SAPLLGEMEQTIGMLERGTIVTKLYGKQRRPD----RRHLMLIRETRQLLWATVATQTPR 63
            ||:| |...:......|..::.|..:.|:     ||:    .|...|..:.:.|.|     :..:
Human    96 FSSMPSEKKISSANDCISFMQAGCELKKV-----RPNSRIYNRFFTLDTDLQALRW-----EPSK 150

  Fly    64 TDYEGA-IQLREIREIRVGKHSKEFR------LFADDCQRFESSKCFVILHGNHFKLKSFSVVAL 121
            .|.|.| :.:..|:|||:||:::.||      ...:||       .|.||||.::  :|..:||.
Human   151 KDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDC-------AFSILHGENY--ESLDLVAN 206

  Fly   122 SEIEADNWVRGLRYMVKDTLGAPYPLQIDR---------WLRREYYQIENVNTHSAKATEQSPAQ 177
            |...|:.||.||||:|.   .:..||....         || :..::..:|:.:.....:.|...
Human   207 SADVANIWVSGLRYLVS---RSKQPLDFMEGNQNTPRFMWL-KTVFEAADVDGNGIMLEDTSVEL 267

  Fly   178 V-----TIKDFKLFL---------AGVSCKMTTGKFMEHFTEDVRRKHDLKFDDFSRLYQKLLLP 228
            :     |:|:.|:.|         ..::.::|..:|.|.|.|...|         ..:|..|:  
Human   268 IKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTR---------PEVYFLLV-- 321

  Fly   229 NGFASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERDV 293
                           ..|::::.:...:|..|||.||   ..:.|:.......||.: :..|...
Human   322 ---------------QISKNKEYLDANDLMLFLEAEQ---GVTHITEDICLDIIRRY-ELSEEGR 367

  Fly   294 QEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYA 358
            |:.:|....|..:|.|.:.|:::.:..:|..||..|||.|:|.:||||||..|||...:....|.
Human   368 QKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYI 432

  Fly   359 RALRMGCRCIELDCWNGPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSL 423
            |||:||||.:|||..:|.||.|.:.:.:.:|:.:.|..||:.|...||.:||||:||.:..:|||
Human   433 RALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSL 497

  Fly   424 EQQRNMAQALIEVFGDMLLTQPCDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGH 488
            .||:.|||.:.:|||:.|.|:....:|.:||||.:|:|.||:|.||||...|:..|         
Human   498 PQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEG--------- 553

  Fly   489 RSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNS 553
                                                                   |:.:      
Human   554 -------------------------------------------------------EVTD------ 557

  Fly   554 EDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLV 618
            ||::..:|...|::.|.:|||                                            
Human   558 EDEEAEMSRRMSVDYNGEQKQ-------------------------------------------- 578

  Fly   619 RESATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFS 683
                                                                             
Human   579 ----------------------------------------------------------------- 578

  Fly   684 IILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHC 748
                                                                         |:.|
Human   579 -------------------------------------------------------------IRLC 582

  Fly   749 RIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDN 813
            |                                                                
Human   583 R---------------------------------------------------------------- 583

  Fly   814 GASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANY 878
                                                                             
Human   584 ----------------------------------------------------------------- 583

  Fly   879 VKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQ 943
                                                                             
Human   584 ----------------------------------------------------------------- 583

  Fly   944 ETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFRE-----HSWIFQEMS 1003
                                               |:|||:...:||.:|:     .|..:.||.
Human   584 -----------------------------------ELSDLVSICKSVQYRDFELSMKSQNYWEMC 613

  Fly  1004 SFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKA 1068
            ||.||:|.: ...:..:.|::|::..:||:||...|:||||.||..|||.|.|::|:|:||....
Human   614 SFSETEASR-IANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPM 677

  Fly  1069 MQLNQAKFRNNGQCGYILKPSFMKSD--SFNPNNP-LCDGLSEVKVSIRLIAARHLFR------G 1124
            |.|:...|..||.|||:|:||.|:.:  .|:.|.. :..|:|.:.:.|::|:.::..:      .
Human   678 MDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAK 742

  Fly  1125 GKSNNPQIVVELIGASFDTGVKYRTK-VNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAE 1188
            |...:|.:.:|:.|...|.. :.||| |.:|..||:::|:.||.|..|:.|::||.|.|:|...:
Human   743 GDVIDPYVCIEIHGIPADCS-EQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGD 806

  Fly  1189 THFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKIAN 1232
             .||.|...|..|::.|||.|.||:...:.:|..:|.::|.|.|
Human   807 -EFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITN 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 38/135 (28%)
PI-PLCc_gamma 323..>470 CDD:176534 68/146 (47%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 0/97 (0%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 3/99 (3%)
SH3_PLCgamma 828..880 CDD:212759 0/51 (0%)
PLCYc 981..1091 CDD:128454 47/114 (41%)
C2_PLC_like 1109..1215 CDD:175974 36/112 (32%)
PLCL1NP_006217.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..61
Interaction with PPP1C 83..222 42/144 (29%)
PH_PLC_eta 115..223 CDD:270170 37/126 (29%)
PH 118..223 CDD:278594 37/123 (30%)
EF-hand_like 315..396 CDD:286375 19/101 (19%)
PLN02228 330..850 CDD:177873 196/996 (20%)
PI-PLCc_PRIP_metazoa 398..688 CDD:176539 125/759 (16%)
Interaction with GABA A beta subunit. /evidence=ECO:0000250 543..567 9/93 (10%)
C2_PLC_like 720..848 CDD:175974 39/129 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1066..1095
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151857
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X101
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.750

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