Protein Alignment sl and PLCD1

DIOPT Version :10

• Sequence 1: NP_476726.2
• Gene: sl / 32601
• FlyBaseID: FBgn0003416
• Length: 1236
• Species: Drosophila melanogaster
• Sequence 2: NP_001124436.1
• Gene: PLCD1 / 5333
• HGNCID: 9060
• Length: 777
• Species: Homo sapiens
• Alignment Length: 1250
• Identity: 274/1250 - (21%)
• Similarity: 434/1250 - (34%)
• Gaps: 523/1250 - (41%)

  Fly     5 SAMSAPLLG-EMEQTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLLWATVATQTPRTDYEG 68
            :|::...|| :.::.:..|.:|:.:.|:.....|  |.....::|..:.:|.. :.:..||....
Human    25 AALNGRRLGLQDDEDLQALLKGSQLLKVKSSSWR--RERFYKLQEDCKTIWQE-SRKVMRTPESQ 86

  Fly    69 AIQLREIREIRVGKHSKEFRLFADDCQRFESSKCFVILHGNHFK--LKSFSVVALSEIEADNWVR 131
            ...:.:|:|:|:|..::....||.|   ....:||.|:    ||  ..:..::|.|..:|.:||.
Human    87 LFSIEDIQEVRMGHRTEGLEKFARD---VPEDRCFSIV----FKDQRNTLDLIAPSPADAQHWVL 144

  Fly   132 GLRYMVKDTLGAPYPLQIDRWLRREYYQIENVNTHSA--KATEQSPAQVTIKDFKLFLAGVSCKM 194
            ||..::..:.......::..|:            ||.  ||.:....:::.|:.:.||..::.::
Human   145 GLHKIIHHSGSMDQRQKLQHWI------------HSCLRKADKNKDNKMSFKELQNFLKELNIQV 197

  Fly   195 TTGKFMEHFTE-DVRRKHDLKFDDFSRLY----QKLLLPNGFASVLSGSGVANFPYSEDQQVVRP 254
            ......:.|.| |..:...|:.::....|    |::.:...||.. :|||..   .|.||.|.
Human   198 DDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEA-AGSGET---LSVDQLVT-- 256

  Fly   255 AELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKY 319
                 ||:.:||:    |.:..|:|..:.:..:..|....:..:|...|:.:|.|.....::..:
Human   257 -----FLQHQQRE----EAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAH 312

  Fly   320 DQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFH 384
            .:|:.||..|||.|.::|||||||..||.:..||.|||.|||..||||:|||||:||:..|.|:|
Human   313 RRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYH 377

  Fly   385 GHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRN 449
            |:|.||||.|.||::.|:|:||.:|.||||||:|.:|:|||||.||:.|..:.|.|||.:|.|..
Human   378 GYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGV 442

  Fly   450 EQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKE 514
            ...||||.||:.||:||.||                ||.....||.||
Human   443 TNSLPSPEQLKGKILLKGKK----------------LGGLLPPGGEGG----------------- 474

  Fly   515 GLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSA 579
                                                                             
Human   475 ----------------------------------------------------------------- 474

  Fly   580 NDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIK 644
                                                    ..||.|.|
Human   475 ----------------------------------------PEATVVSD----------------- 482

  Fly   645 LKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKE 709
                                                                ||
Human   483 ----------------------------------------------------ED----------- 484

  Fly   710 QAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYY 774
                                                                             
Human   485 ----------------------------------------------------------------- 484

  Fly   775 TRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANK 839
                                     |||:.:
Human   485 -------------------------EAAEME---------------------------------- 490

  Fly   840 PDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSI 904
             ||      |:.:.||                 |.|
Human   491 -DE------AVRSRVQ-----------------HKP----------------------------- 502

  Fly   905 EIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRK 969
                                                                             
Human   503 ----------------------------------------------------------------- 502

  Fly   970 KERTARVAKEMSDLIIYFRSVPFREHS------WIFQEMSSFPETKAEKQFFQQNTQLFLSYHRN 1028
            ||...|:|:|:||::||.:||.|...|      ..|.||:||.|.:| .:..|::...|:.::..
Human   503 KEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRA-LRLLQESGNGFVRHNVG 566

  Fly  1029 QISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMK- 1092
            .:||:||.|.|.||||::|:..||.|.|::|||:||....|.:.|.:|::||.|||:|||:|::
Human   567 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRD 631

  Fly  1093 -SDSFNPNNPLCDG--LSEVKVSIRLIAARHLFRGGKSNN----PQIVVELIGASFDTGVKYRTK 1150
             :.:||| ..|..|  .:..:::||:|:.:.|.:..|:.|    |::.||:.|.|.|...:....
Human   632 PNGTFNP-RALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAV 695

  Fly  1151 VNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKF 1215
            :..|||||.|:....|.|..|..|::||.|:|.|..::..||.|:..||..::||||.|.|.:|.
Human   696 ITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKN 760

  Fly  1216 SEELELSSLLINIKI 1230
            .::...::|.:.|.:
Human   761 GDQHPSATLFVKISL 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	28/126 (22%)
		EFh_PI-PLCgamma	152..311	CDD:320031	35/165 (21%)
		EF-hand motif	152..191	CDD:320031	8/40 (20%)
		EF-hand motif	198..226	CDD:320031	6/32 (19%)
		EF-hand motif	230..265	CDD:320031	11/34 (32%)
		EF-hand motif	277..311	CDD:320031	7/33 (21%)
		PI-PLCc_gamma	323..>470	CDD:176534	84/146 (58%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	4/97 (4%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	2/99 (2%)
		SH3_PLCgamma	828..880	CDD:212759	7/51 (14%)
		PLCYc	981..1091	CDD:128454	48/115 (42%)
		C2_PLC_like	1109..1215	CDD:175974	38/109 (35%)
PLCD1	NP_001124436.1	PH_PLC_delta	43..160	CDD:270169	28/126 (22%)
		EFh_PI-PLCdelta1	165..304	CDD:320047	35/165 (21%)
		EF-hand motif	165..194	CDD:320047	8/40 (20%)
		EF-hand motif	201..230	CDD:320047	5/28 (18%)
		EF-hand motif	234..265	CDD:320047	13/45 (29%)
		EF-hand motif	271..304	CDD:320047	6/32 (19%)
		PI-PLCc_delta	316..617	CDD:176535	152/761 (20%)
		C2_PLC_like	650..776	CDD:175974	41/125 (33%)