DRSC/TRiP Functional Genomics Resources

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Protein Alignment sl and PLCB4

DIOPT Version :9

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_001364071.1 Gene:PLCB4 / 5332 HGNCID:9059 Length:1206 Species:Homo sapiens


Alignment Length:1228 Identity:274/1228 - (22%)
Similarity:405/1228 - (32%) Gaps:536/1228 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 IREIRVGKHSKEFRLFA---------DDCQRFESSKCFVILHGNHFKLKSFS-VVALSEIEADNW 129
            |..||.|...|:.::.|         :|.:    .:...:..|......||: :||.:......|
Human    65 INSIRSGAIPKDPKILAALEAVGKSENDLE----GRIVCVCSGTDLVNISFTYMVAENPEVTKQW 125

  Fly   130 VRGLRYMVKDTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSP-----------AQVTIKDF 183
            |.|||.::                            |:.:|...||           |.:|..:.
Human   126 VEGLRSII----------------------------HNFRANNVSPMTCLKKHWMKLAFMTNTNG 162

  Fly   184 KLFLAGVSCKMTTGKFMEHFTEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSED 248
            |:.:..::....:||     ||.|          ..:..::|.||:|....:..:..:...:.|.
Human   163 KIPVRSITRTFASGK-----TEKV----------IFQALKELGLPSGKNDEIEPTAFSYEKFYEL 212

  Fly   249 QQVVRPA---------------------ELKQFLETEQRDVSASEI----SSAAIASFIRDFVQD 288
            .|.:.|.                     :|..||...|||...:||    ..|..|..|.:..:.
Human   213 TQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEP 277

  Fly   289 VERDVQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMD-------MNLPLSSYWIASSHNTYLTGD 346
            .|...::..::...|..:|.|.:|       ..||:|       |:.||:.|:|:|||||||||.
Human   278 DEDLKKKGLISSDGFCRYLMSDEN-------APVFLDRLELYQEMDHPLAHYFISSSHNTYLTGR 335

  Fly   347 QFSSESSCEAYARALRMGCRCIELDCWN--GPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSS 409
            ||..:||.|.|.:.|..||||:|||||:  |.|..|.|.||..:.:.|.|.|||:.||:.||.:|
Human   336 QFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTS 400

  Fly   410 EYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRNEQH-------LPSPYQLRRKIILKH 467
            |||||||.|.:||..||..|::...::|||:||.|..   |.|       ||||..|:|||::|:
Human   401 EYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQAL---ESHPLEPGRALPSPNDLKRKILIKN 462

  Fly   468 KKL-PQFDDIANGISSTGSLGHRSSLGGAGGGAHGEN--DGENVRKVFKEGLLYFKDPVDKSWNL 529
            |:| |:.:        ...|....|:..||..|...|  :.:|..::         :..|:... 
Human   463 KRLKPEVE--------KKQLEALRSMMEAGESASPANILEDDNEEEI---------ESADQEEE- 509

  Fly   530 YQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKL 594
                 .|.|..:.:|::.        ||.|              .|:..||..            
Human   510 -----AHPEFKFGNELSA--------DDLG--------------HKEAVANSV------------ 535

  Fly   595 EGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVEN 659
               :|.:||                                         |:|||.......|| 
Human   536 ---KKASDD-----------------------------------------LEHENNKKGLVTVE- 555

  Fly   660 FVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFL 724
                                                 ::|.|                       
Human   556 -------------------------------------DEQAW----------------------- 560

  Fly   725 VRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPV 789
                                      |...:..|..|.....|.::|||            :.||
Human   561 --------------------------MASYKYVGATTNIHPYLSTMINY------------AQPV 587

  Fly   790 SQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNV 854
            .           .||.|                                                
Human   588 K-----------FQGFH------------------------------------------------ 593

  Fly   855 QRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDP 919
                                                                             
Human   594 ----------------------------------------------------------------- 593

  Fly   920 GIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLI 984
                                                       :|.||.                
Human   594 -------------------------------------------VAEERN---------------- 599

  Fly   985 IYFRSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMP 1049
                         |...||||.|: ....:.:.:...|::|::.|:||:||||.|:||||:.|..
Human   600 -------------IHYNMSSFNES-VGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQI 650

  Fly  1050 FWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMK--SDSFNP--NNPLCDGLSEVK 1110
            |||.|.||::|||||.|.||||||.||..||.|||:|||.||:  ..:|:|  ..|: ||:....
Human   651 FWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPV-DGVIAAT 714

  Fly  1111 VSIRLIAARHLFRGGKSNNPQIVVELIGASFDTGVK-YRTK-VNENGFNPVWNESCEFNVRN--- 1170
            .|:::|:.:  |...|.....:.|::.|...||..| :||: |..||.|||:||. .|..|.   
Human   715 CSVQVISGQ--FLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEE-SFVFRKVIL 776

  Fly  1171 PQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINI 1228
            |..|:||..|.|::    ...|.|...||..::.|||.:.|||:.::.|.|.::..||
Human   777 PDLAVLRIAVYDDN----NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNI 830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 17/81 (21%)
PI-PLCc_gamma 323..>470 CDD:176534 79/162 (49%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 9/97 (9%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 11/99 (11%)
SH3_PLCgamma 828..880 CDD:212759 0/51 (0%)
PLCYc 981..1091 CDD:128454 49/109 (45%)
C2_PLC_like 1109..1215 CDD:175974 37/110 (34%)
PLCB4NP_001364071.1 PH_PLC_beta 17..143 CDD:270167 19/109 (17%)
EFh_PI-PLCbeta4 148..300 CDD:320041 30/166 (18%)
PI-PLCc_beta 312..680 CDD:176533 163/767 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 482..511 6/43 (14%)
C2_PLC_like 714..830 CDD:175974 39/122 (32%)
PTZ00121 <859..1206 CDD:173412
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 875..907
DUF1154 926..967 CDD:399553
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1094..1122
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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