DRSC/TRiP Functional Genomics Resources

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Protein Alignment sl and PLCB3

DIOPT Version :10

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_000923.1 Gene:PLCB3 / 5331 HGNCID:9056 Length:1234 Species:Homo sapiens


Alignment Length:1259 Identity:279/1259 - (22%)
Similarity:428/1259 - (33%) Gaps:478/1259 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 EMEQTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQ---LLWATVATQTPRTDYEGAIQLREI 75
            |....:..|.||   :|..........|:|:.:|....   |.|.     .|..:.: .:.:..|
Human    14 EPPTVVETLRRG---SKFIKWDEETSSRNLVTLRVDPNGFFLYWT-----GPNMEVD-TLDISSI 69

  Fly    76 REIRVGKHS--------KEFRLFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRG 132
            |:.|.|:::        :|...|.....|.|.....|:...:.......:.:|:.:..|..|...
Human    70 RDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEE 134

  Fly   133 LRYMVKDTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKD-FKLFLAGVSCKMTT 196
            |..:..:.|.  .....:.:||:.|.::        |.......::.:|: .|:|.|.   |...
Human   135 LFKLAMNILA--QNASRNTFLRKAYTKL--------KLQVNQDGRIPVKNILKMFSAD---KKRV 186

  Fly   197 GKFMEHFTEDVRRKHDLKFDDFS-----RLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAE 256
            ...:|.......|...::.|:||     |...||.|......:|...|....||...:|      
Human   187 ETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQ------ 245

  Fly   257 LKQFLETEQRDVSASEI-------SSAAIASFIRDF---VQDVERDVQEPYLTFPEFVDFLFSKQ 311
            |..|:..:|||...:|:       |.|.:  .|..:   .|.:|||    .::...|..:|..::
Human   246 LMDFINQKQRDPRLNEVLYPPLRPSQARL--LIEKYEPNQQFLERD----QMSMEGFSRYLGGEE 304

  Fly   312 NDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNG- 375
            |.:...:...:..||..|||:|:|.||||||||..|.:..||.|.|.:||..||||:|||.|.| 
Human   305 NGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGR 369

  Fly   376 -PDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNC-SLEQQRNMAQALIEVFG 438
             |:..|:|.||.|:|:::...||::.|.:.||.:|.||||||.|.:. |.:||..||:....:||
Human   370 PPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFG 434

  Fly   439 DMLLTQPCDRNE----QHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGA 499
            |.||.:|.|:..    ..||||..|..:|::|:||                 .||.|.||.....
Human   435 DALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKK-----------------RHRPSAGGPDSAG 482

  Fly   500 HGENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSC 564
            .                   |.|:::|               :|.::|             ||:.
Human   483 R-------------------KRPLEQS---------------NSALSE-------------SSAA 500

  Fly   565 SLNSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYS 629
            :..|:.|.....:.:...|..||.                                    ||   
Human   501 TEPSSPQLGSPSSDSCPGLSNGEE------------------------------------VG--- 526

  Fly   630 LSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPK 694
                                                                    |::|..:|:
Human   527 --------------------------------------------------------LEKPSLEPQ 535

  Fly   695 KHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGI 759
                         |...::||.|   |.:::.|                                
Human   536 -------------KSLGDEGLNR---GPYVLGP-------------------------------- 552

  Fly   760 DTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLE 824
                                                                             
Human   553 ----------------------------------------------------------------- 552

  Fly   825 ENVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDY 889
                        |::.||..                                      |...|:.
Human   553 ------------ADREDEEE--------------------------------------DEEEEEQ 567

  Fly   890 NSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQ 954
            ....:..||..|.|.|:                                                
Human   568 TDPKKPTTDEGTASSEV------------------------------------------------ 584

  Fly   955 EAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPF------REHSWIFQEMSSFPETKAEKQ 1013
                                ...:|||.|:.|...|.|      |:.:..| |||||.||||.:|
Human   585 --------------------NATEEMSTLVNYIEPVKFKSFEAARKRNKCF-EMSSFVETKAMEQ 628

  Fly  1014 FFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRN 1078
            ..:...: |:.|::.|:||:||||.|:||||:.|..|||||.|::|||:||.|.|||||...|..
Human   629 LTKSPME-FVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEY 692

  Fly  1079 NGQCGYILKPSFMK--SDSFNP-NNPLCDGLSEVKVSIRLIAARHLFRGGKSNNPQIVVELIGAS 1140
            ||:.||:|||.||:  ..||:| ...:.||:....:.:::|:.:  |...:.....:.|::.|..
Human   693 NGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQ--FLSDRKVGIYVEVDMFGLP 755

  Fly  1141 FDTGVKYRTKVNE-NGFNPVWNES-CEF-NVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCI 1202
            .||..||||:.:: |.|||||:|. .:| .|..|..|.||....:|.    ..|:.....|::.|
Human   756 VDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEG----GKFVGHRILPVSAI 816

  Fly  1203 RQGYRSVILRNKFSEELELSSLLI 1226
            |.||..|.|||:.::.|.|.:|||
Human   817 RSGYHYVCLRNEANQPLCLPALLI 840

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 24/135 (18%)
EFh_PI-PLCgamma 152..311 CDD:320031 38/174 (22%)
EF-hand motif 152..191 CDD:320031 8/39 (21%)
EF-hand motif 198..226 CDD:320031 7/32 (22%)
EF-hand motif 230..265 CDD:320031 7/34 (21%)
EF-hand motif 277..311 CDD:320031 7/36 (19%)
PI-PLCc_gamma 323..>470 CDD:176534 71/153 (46%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 4/97 (4%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 6/99 (6%)
SH3_PLCgamma 828..880 CDD:212759 3/51 (6%)
PLCYc 981..1091 CDD:128454 57/115 (50%)
C2_PLC_like 1109..1215 CDD:175974 34/108 (31%)
PLCB3NP_000923.1 PH_PLC_beta 22..149 CDD:270167 24/137 (18%)
EFh_PI-PLCbeta3 154..304 CDD:320040 37/172 (22%)
EF-hand motif 154..183 CDD:320040 7/39 (18%)
EF-hand motif 187..216 CDD:320040 5/28 (18%)
EF-hand motif 225..254 CDD:320040 7/34 (21%)
EF-hand motif 271..304 CDD:320040 8/38 (21%)
PI-PLCc_beta3 316..693 CDD:176562 162/768 (21%)
PLN02952 <318..833 CDD:178538 210/912 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..587 40/509 (8%)
PRK06975 <873..>1066 CDD:235899
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 887..937
DUF1154 951..990 CDD:461969
PLC-beta_C 1029..1202 CDD:462571
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1198..1234
Interaction with SHANK2. /evidence=ECO:0000250 1231..1234
Blue background indicates that the domain is not in the aligned region.

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