DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and PLCB2

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	XP_024305716.1	Gene:	PLCB2 / 5330	HGNCID:	9055	Length:	1208	Species:	Homo sapiens

Alignment Length:	1279	Identity:	272/1279 - (21%)
Similarity:	406/1279 - (31%)	Gaps:	560/1279 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PDRRHLMLIRETRQLLW---ATVATQT-PRTDYEG-------------AIQLREIREIRVGKHSK 85
            |.:....|.:..|.:.|   .|||:.. .|.|.:|             .:.:..||:.|.||.:|
Human    10 PPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAK 74

  Fly    86 ---------EFRL-FADDCQRFESSKCFVILHGNHFKLKSFSVVA---LSEIEADN--------- 128
                     .|.: |.|                |.|.||:.:||:   :.::...|
Human    75 MPKSQKLRDVFNMDFPD----------------NSFLLKTLTVVSGPDMVDLTFHNFVSYKENVG 123

  Fly   129 --WVRGLRYMVKD--TLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKD-FKLFLA 188
              |...:..:||.  |..|.....:|:.|.:...|:            .|..::.:|: |::|.|
Human   124 KAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQL------------NSEGKIPVKNFFQMFPA 176

  Fly   189 G--------VSCKMTTGKFMEHFTEDVRRKHDLKFDDFSR-LYQKLLL-----PNGFASVLSGSG 239
            .        .:|.:..||           ...:..:||.. :|:..|:     |. ...:.:...
Human   177 DRKRVEAALSACHLPKGK-----------NDAINPEDFPEPVYKSFLMSLCPRPE-IDEIFTSYH 229

  Fly   240 VANFPYSEDQQVVRPAELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEP-------- 296
            ....||...:      .|.:|:..:|||   |.::|........|.||.: .|..||
Human   230 AKAKPYMTKE------HLTKFINQKQRD---SRLNSLLFPPARPDQVQGL-IDKYEPSGINAQRG 284

  Fly   297 YLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARAL 361
            .|:....|.||...:|.:.......:..||..||:.|:|.||||||||..|||..||.|.|.:.|
Human   285 QLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVL 349

  Fly   362 RMGCRCIELDCWNG--PDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNC-SL 423
            ..||||:|||||.|  ||..|.|.||.|:|:.|.|.:.|:.|.:.||.:|.||:|||.|.:. |.
Human   350 LSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSP 414

  Fly   424 EQQRNMAQALIEVFGDMLLTQPCDRNEQH----LPSPYQLRRKIILKHKKLPQFDDIANGISSTG 484
            .||..||:....:|||||||:|.::....    ||||..||.||::|:|| .||.
Human   415 RQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKK-NQFS---------- 468

  Fly   485 SLGHRSSLGGAGGGAHGEND-----GENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSE 544
              |..||....||.|.|.:.     ||......:||                           :|
Human   469 --GPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEG---------------------------TE 504

  Fly   545 INESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYK 609
            :.|......|:::.|         |:.:::
Human   505 LEEEEVEEEEEEESG---------NLDEEE----------------------------------- 525

  Fly   610 HFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRK 674
                                                      ||
Human   526 ------------------------------------------IK--------------------- 527

  Fly   675 NMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISF 739
                                             |.|:::|...||:.:
Human   528 ---------------------------------KMQSDEGTAGLEVTA----------------- 542

  Fly   740 TINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQG 804
                                    :|.:.||:||
Human   543 ------------------------YEEMSSLVNY------------------------------- 552

  Fly   805 DHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGM 869
                                                             :|
Human   553 -------------------------------------------------IQ-------------- 554

  Fly   870 IKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQN 934
                 |..:|.                                 ||.:.|
Human   555 -----PTKFVS---------------------------------FEFSAP--------------- 566

  Fly   935 PFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFREHSWIF 999
                                  .|.....:..:.||.|                       |::
Human   567 ----------------------RLFTCIFSGHKHKKNR-----------------------SYV- 585

  Fly  1000 QEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQT 1064
              :|||.|.||.....:.:.| |:.|::.|:||:||||.|:||||:.|..|||.|.||:|||:||
Human   586 --ISSFTELKAYDLLSKASVQ-FVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQT 647

  Fly  1065 GDKAMQLNQAKFRNNGQCGYILKPSFMK--SDSFNP-NNPLCDGLSEVKVSIRLIAARHLFRGGK 1126
            .|..||.|.|.|..|||.||:||..||:  ...||| :....|.:....:||.:|:.:  |...:
Human   648 MDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQ--FLSER 710

  Fly  1127 SNNPQIVVELIGASFDTGVKYRTKV--NENGFNPVWNESCEF---NVRNPQFAILRFEVQDEDMF 1186
            |....:.|||.|...|...:||||:  :.|..||||.|. .|   .:..|:.|.||..|.:|.
Human   711 SVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEE-PFVFEKILMPELASLRVAVMEEG-- 772

  Fly  1187 AETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKI 1230
              ..|:.....|:..:..||..:.|.::.:..|.:.:|.|.:::
Human   773 --NKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEM 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	31/151 (21%)
		PI-PLCc_gamma	323..>470	CDD:176534	76/153 (50%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	2/97 (2%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	10/99 (10%)
		SH3_PLCgamma	828..880	CDD:212759	2/51 (4%)
		PLCYc	981..1091	CDD:128454	47/109 (43%)
		C2_PLC_like	1109..1215	CDD:175974	32/110 (29%)
PLCB2	XP_024305716.1	PH_PLC_beta	17..144	CDD:270167	30/142 (21%)
		EFh_PI-PLCbeta2	149..299	CDD:320039	35/183 (19%)
		EF-hand motif	149..178	CDD:320039	8/40 (20%)
		EF-hand motif	182..211	CDD:320039	6/39 (15%)
		EF-hand motif	220..249	CDD:320039	4/35 (11%)
		EF-hand motif	266..299	CDD:320039	9/33 (27%)
		PI-PLCc_beta2	311..662	CDD:176561	157/767 (20%)
		C2_PLC_like	694..815	CDD:175974	35/128 (27%)
		PLC-beta_C	991..1176	CDD:312287
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151859
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750