DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and norpA

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster

Alignment Length:	1245	Identity:	273/1245 - (21%)
Similarity:	402/1245 - (32%)	Gaps:	533/1245 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 WATVATQTPRTDYE-----------------------GAIQLREIREIRVGKHSKEFRLF----- 90
            |.....:|...|:|                       ..|:|.::.:||.|...|:.::.
  Fly    26 WFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTK 90

  Fly    91 --ADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLR---YMVKDTLGAPYPLQID 150
              ..:....:.....:..:.::..:....|:......|..|:.|:|   :.||.....|......
  Fly    91 KNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVKANNICPMMCLRK 155

  Fly   151 RWLRREYYQIENVNTHSAKATEQSPAQVTIKDF-KLFLAGVSCKMTTGKFMEHFTEDVRR----K 210
            .|:|..|            ..|:| .::.:|.. |.|.:|.:.|:......:....|.:.    |
  Fly   156 HWMRLSY------------CVEKS-GKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTK 207

  Fly   211 HDLKFDDFSRLYQKLLLPNG----FASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSAS 271
            ....||.|..||.|:...|.    |.|:..|.          |..:...:..||:..:|||...:
  Fly   208 EQFTFDKFYALYHKVCPRNDIEELFTSITKGK----------QDFISLEQFIQFMNDKQRDPRMN 262

  Fly   272 EI-----SSAAIASFIRDFVQDVE--RDVQEPYLTFPEFVDFLFSKQN-DLWNSKYDQVFMDMNL 328
            ||     ........|.|:..|.|  ::||   ::...|..:|.|.:| .::..:.| .:|:|:.
  Fly   263 EILYPLYEEKRCTEIINDYELDEEKKKNVQ---MSLDGFKRYLMSDENAPVFLDRLD-FYMEMDQ 323

  Fly   329 PLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWN--GPDNLPYIFHGHTITSK 391
            ||:.|:|.|||||||:|.|...:||.|.|.:.|..||||:||||||  |.|..|.:.|||...::
  Fly   324 PLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTE 388

  Fly   392 IKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRNEQH---- 452
            |.|.|.|:.|.|.||.|||||||||.|.:|:..||..:|:...:.|||:||.:|.   ..|
  Fly   389 ILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPL---PDHPLDP 450

  Fly   453 ---LPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKE 514
               ||.|.:|:|||::|:|::
  Fly   451 GLPLPPPCKLKRKILIKNKRM-------------------------------------------- 471

  Fly   515 GLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSA 579
                 |..|:|         ...||....|:       ..|||               .::|.||
  Fly   472 -----KPEVEK---------VELELWLKGEL-------KTDDD---------------PEEDASA 500

  Fly   580 NDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIK 644
                            |...||
  Fly   501 ----------------GKPPEA------------------------------------------- 506

  Fly   645 LKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKE 709
                                                     ...|.|.|:
  Fly   507 -----------------------------------------AAAPAPAPE--------------- 515

  Fly   710 QAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYY 774

  Fly   516 ----------------------------------------------------------------- 515

  Fly   775 TRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANK 839
                                ..|.||.|.....|...:..|:||.||.
  Fly   516 --------------------AAAAAEGAAEGGGGAEAEAAAANYSGST----------------- 543

  Fly   840 PDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSI 904
                        |||..     |:...         .||.:.|
  Fly   544 ------------TNVHP-----WLSSM---------VNYAQPI---------------------- 560

  Fly   905 EIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRK 969
                               |.|            |||         |||::.
  Fly   561 -------------------KFQ------------GFD---------KAIEKN------------- 572

  Fly   970 KERTARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVY 1034
                                        |...||||.|: |...:.:|::..|::|::.|:||:|
  Fly   573 ----------------------------IAHNMSSFAES-AGMNYLKQSSIDFVNYNKRQMSRIY 608

  Fly  1035 PKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMK--SDSFN 1097
            |||.|.||||:.|..|||.|.||::||:|:.|..|||||.||..||.|||:|||.||:  ...|:
  Fly   609 PKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFD 673

  Fly  1098 P--NNPLCDGLSEVKVSIRLIAARHLFRGGKSNNPQIVVELIGASFDTGVK-YRTK-VNENGFNP 1158
            |  :.|: ||:...:.|:::||.:  |...|.....:.|::.|...||..| :||: |..||.||
  Fly   674 PFADAPV-DGVIAAQCSVKVIAGQ--FLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNP 735

  Fly  1159 VWNESCEFNVRN---PQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELE 1220
            |:||. .|..|.   |..|:|||.|.:|    ....:.|...||..::.|||.|.||.:.:..:.
  Fly   736 VYNED-PFVFRKVVLPDLAVLRFGVYEE----SGKILGQRILPLDGLQAGYRHVSLRTEANFPMS 795

  Fly  1221 LSSLLINIKI 1230
            |..|.:||::
  Fly   796 LPMLFVNIEL 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	18/125 (14%)
		PI-PLCc_gamma	323..>470	CDD:176534	74/155 (48%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	3/97 (3%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	0/99 (0%)
		SH3_PLCgamma	828..880	CDD:212759	6/51 (12%)
		PLCYc	981..1091	CDD:128454	48/109 (44%)
		C2_PLC_like	1109..1215	CDD:175974	38/110 (35%)
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	17/122 (14%)
		PLN02952	224..786	CDD:178538	231/1013 (23%)
		EF-hand_like	227..318	CDD:286375	22/104 (21%)
		PI-PLCc_beta	318..653	CDD:176533	157/764 (21%)
		C2_PLC_like	689..806	CDD:175974	42/124 (34%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456391
Domainoid	1	1.000	112	1.000	Domainoid score	I2055
eggNOG	1	0.900	-	-		E1_KOG0169
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2757
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10336
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850