DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sl and Plch1

DIOPT Version :9

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:XP_017446352.2 Gene:Plch1 / 310463 RGDID:1561991 Length:1703 Species:Rattus norvegicus


Alignment Length:1243 Identity:306/1243 - (24%)
Similarity:491/1243 - (39%) Gaps:422/1243 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 MEQTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETR-QLLWATVATQTPRTDYEGAIQLREIREI 78
            :|:.:.:::.||.:.||  |:.......|..:.|.| :|.|     :..|...:..|.:..|.::
  Rat    27 VERCMSVMQSGTQMIKL--KRGTKGLVRLFYLDEHRTRLRW-----RPSRKSEKAKILIDSIYKV 84

  Fly    79 RVGKHSKEFRLFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMV-----K 138
            ..|:.|:.|...|:.  .|:.|.||.|.||||  ::|..::..:..||..|:.||:|::     :
  Rat    85 TEGRQSEIFHRQAEG--NFDPSCCFTIYHGNH--MESLDLITSNPEEARTWITGLKYLMAGISDE 145

  Fly   139 DTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGKFMEHF 203
            |:| |......|:|:::.:          .:|.:.....:.|::....:..::..:...|..:.|
  Rat   146 DSL-AKRQRTHDQWVKQTF----------EEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMF 199

  Fly   204 TE-DV-RRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQR 266
            .| |. ..:..|.|::|...|:.:.|......:|       ..||:.:..:...||.|||:.||:
  Rat   200 QEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLL-------LSYSDKKDHLTVEELAQFLKVEQK 257

  Fly   267 DVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNLPLS 331
               .|.::.......|:.|....|..|:. .|....|.:|:.|...|::|..:.:|:.||:.||.
  Rat   258 ---MSNVTLDYCLDVIKKFEVSEENKVKN-VLGIEGFTNFMRSPACDVFNPLHHEVYQDMDQPLC 318

  Fly   332 SYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFHGHTITSKIKFMD 396
            :|:|||||||||||||..|:|..:.|||.|:.||||:|:|||:|||..|.:.||:|:||||.|.|
  Rat   319 NYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFKD 383

  Fly   397 VIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRNE-QHLPSPYQLR 460
            |::||..|||..:|:|||||||.:||::|||.:||.|..:|.|.|.....|..| :.||||..|:
  Rat   384 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFQDKLDLSSVDTGECRQLPSPQSLK 448

  Fly   461 RKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDPVDK 525
            .||::|.||||.                           |..:|.|                   
  Rat   449 GKILVKGKKLPY---------------------------HLGDDAE------------------- 467

  Fly   526 SWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGENWF 590
                                    .|...|:|                                 
  Rat   468 ------------------------EGEVSDED--------------------------------- 475

  Fly   591 HGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYY 655
                     .||::                                 .:.|:.||.:.||:.::.
  Rat   476 ---------SADEI---------------------------------EDECKFKLHYSNGTTEHQ 498

  Fly   656 LVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEI 720
             ||:|:...|.||                 |||...:.|:..|                      
  Rat   499 -VESFIRKKLDSL-----------------LKESQIRDKEDPD---------------------- 523

  Fly   721 GSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKL 785
                             |||:                                            
  Rat   524 -----------------SFTV-------------------------------------------- 527

  Fly   786 SHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAI 850
                      :||.:|.   |.|          :.::|::|:..|........:....:|.||..
  Rat   528 ----------RALLKAT---HEG----------LNAHLKQNLDVKESGKKSHGRSLMANFGKHKQ 569

  Fly   851 ITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFE 915
            .|...|..|.                       ||.::.::|...|.:|                
  Rat   570 KTPKSRSKSY-----------------------STDDEEDTLQNPGKEG---------------- 595

  Fly   916 SNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVAKEM 980
                |.:::|                                          .::.||.::.:|:
  Rat   596 ----GQLYRL------------------------------------------GRRRRTMKLCREL 614

  Fly   981 SDLIIYFRSVPFREHSWIFQE-----MSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRL 1040
            |||::|..||..::   |..:     :.||.||:|. |..||.::.|:.|::.|::|:||...|:
  Rat   615 SDLVVYTNSVAAQD---IVDDGTTGNVLSFSETRAH-QVVQQKSEQFMIYNQKQLTRIYPSAYRI 675

  Fly  1041 DSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSDSFNP--NNPLC 1103
            |||||||:|:||.|.|::|||||:..:.||:|:|||:.||.|||||||..|...:|||  .:|| 
  Rat   676 DSSNFNPLPYWNAGCQLVALNYQSEGRMMQINRAKFKANGNCGYILKPQQMCKGTFNPLSGDPL- 739

  Fly  1104 DGLSEVKVSIRLIAARHLFR--------GGKSNNPQIVVELIGASFDTGVKYRTKVNENGFNPVW 1160
            ....:.::.:::|:.:.|.:        .|:..:|.:.||:||...|........|::|||||||
  Rat   740 PANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVW 804

  Fly  1161 NESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLL 1225
            .|:..|.|..|:.|::||.|.|.|.... .|:.|.....:.:..|||.|.|     |.|..:|:.
  Rat   805 EETLTFTVHMPEIALVRFLVWDHDPIGR-DFVGQRTVTFSSLVPGYRHVYL-----EGLTEASIF 863

  Fly  1226 INIKIANV 1233
            ::|.|..:
  Rat   864 VHITINEI 871

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 36/130 (28%)
PI-PLCc_gamma 323..>470 CDD:176534 81/147 (55%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 13/97 (13%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 4/99 (4%)
SH3_PLCgamma 828..880 CDD:212759 7/51 (14%)
PLCYc 981..1091 CDD:128454 54/114 (47%)
C2_PLC_like 1109..1215 CDD:175974 34/113 (30%)
Plch1XP_017446352.2 PH-like 34..140 CDD:418428 33/116 (28%)
EFh_PI-PLCeta1 158..298 CDD:320050 31/160 (19%)
EF-hand motif 158..187 CDD:320050 3/38 (8%)
EF-hand motif 194..223 CDD:320050 8/28 (29%)
EF-hand motif 228..256 CDD:320050 8/34 (24%)
EF-hand motif 265..298 CDD:320050 8/33 (24%)
PI-PLCc_eta1 310..714 CDD:176569 180/761 (24%)
C2_PLC_like 744..868 CDD:175974 38/129 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345386
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.750

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