DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and Plcg2

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	NP_058864.1	Gene:	Plcg2 / 29337	RGDID:	3348	Length:	1265	Species:	Rattus norvegicus

Alignment Length:	1259	Identity:	471/1259 - (37%)
Similarity:	715/1259 - (56%)	Gaps:	136/1259 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EMEQTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLLWATVATQTPRTDYEGAIQLREIREI 78
            |..|....||.||::|....::..|:||.:.:|.||||:.|:..|.:     .||.:.:.||:||
  Rat    14 EKSQIKRALELGTVMTVFSARKSTPERRTVQMIMETRQVAWSKTADK-----IEGFLDIMEIKEI 73

  Fly    79 RVGKHSKEFRLFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMVKDTLGA 143
            |.||:||:|.  .....|.::..||.|.:|..|.|.:.|:...|:.:|..|:.||:.:.::.:.|
  Rat    74 RPGKNSKDFE--RAKAVRHKADCCFTIFYGTQFVLSTLSLATDSKEDAVKWLSGLKILHQEAMNA 136

  Fly   144 PYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGKFM-EHFTEDV 207
            ..|..|:.|||::.|.::....:|          :::::.|..|..|:.|::..||: :...|..
  Rat   137 STPTMIESWLRKQIYSVDQTRRNS----------ISLRELKTILPLVNFKVSGIKFLKDKLVEIG 191

  Fly   208 RRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVV------RP-------AELKQ 259
            .:|.:|.|:.|...|:||:.... .|:|.       .:.:|..|.      ||       .:.::
  Rat   192 AQKDELSFEQFHLFYKKLMFEQQ-KSILD-------EFKKDSSVFILGNTDRPDASAVYLQDFQR 248

  Fly   260 FLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFM 324
            ||..||:::.|.:::.  :...:..|:.|..|:..||:|...||:.:|||::|.:|:.|||.|.|
  Rat   249 FLLHEQQELWAQDLNK--VRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDM 311

  Fly   325 -DMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFHGHTI 388
             |||.|||.|||:|||||||||||..||||.|||.|.||.||||||||||:|||..|.|:||.|.
  Rat   312 QDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDCWDGPDGKPIIYHGWTR 376

  Fly   389 TSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRNEQHL 453
            |:||||.||::.|:||||.:|.:|||||||::||:||||:||:...||.||:|||:|.:.:...|
  Rat   377 TTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKVFKEVLGDLLLTKPTEASADQL 441

  Fly   454 PSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGLLY 518
            |||.|||.|||:|||||....|:...:                      .|.::..|.  :|.||
  Rat   442 PSPSQLREKIIIKHKKLGPRGDVDVNV----------------------EDKKDEHKT--QGELY 482

  Fly   519 FKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSANDEL 583
            ..|.:|:.|..:...:...:|.:|.:|.::    .|:|..                :||... ||
  Rat   483 MWDSIDQKWTRHYCAIADAKLSFSDDIEQT----VEEDPV----------------QDTPPT-EL 526

  Fly   584 HFGENWFHGKLEGGRKEADDLLKKY-KHFG--DGTFLVRESATFVGDYSLSFWRRNRPNHCRIKL 645
            ||||.|||.|:| .|..|:.||::| ...|  |||||||||.||..||:|||||..|..||||:.
  Rat   527 HFGEKWFHKKVE-SRTSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRS 590

  Fly   646 KHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQ 710
            ..|.|.:||||.:|..|:|:|:||.:||:..||.:||.:.|.:|||.|..||.:.|::...::.:
  Rat   591 TMEGGVMKYYLTDNLTFNSIYALIQHYREAHLRCAEFELRLTDPVPNPNPHESKPWYYDRLSRGE 655

  Fly   711 AEQGLYRL-EIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDT-MNFESLVSLINY 773
            ||..|.|: ..|:||:|.. :..:::.|:|....|:|||||.::||.:.:.| ..|||||.|::|
  Rat   656 AEDMLMRIPRDGAFLIRKR-EGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSY 719

  Fly   774 YTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNG----ASNYMG-SNLEENV---TCK 830
            |.::.|||.::|.:||:.|||.:...|         .|.|.    :..|:. |.:..::   |.|
  Rat   720 YEKHALYRKMRLRYPVTPELLERYNME---------RDINSLYDVSRMYVDPSEINPSMPQRTVK 775

  Fly   831 ALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEE 895
            |||.|||.:.|||:|.:.|:|.||.::...||.||||..|:::.|:|||:  |.:..|...:.::
  Rat   776 ALYDYKAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVE--DISAGDAEEMEKQ 838

  Fly   896 GTD---------GRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQN--PFVIGFDNQETAYEW 949
            ..:         |..| :..:..|.:....|....:|.|:   |..|.  |.....|..|..:||
  Rat   839 IIEDNPLGSLCRGILD-LNTYNVVKAPQGKNQKAFVFILE---PKKQGDPPVEFATDRVEELFEW 899

  Fly   950 IKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFR-SVPFREH--SWIFQEMSSFPETKAE 1011
            .::|:|.........:..:..||...:|.|:|||::|.: :...::|  :..|:|:.||.||||:
  Rat   900 FQSIREITWKIDTKENNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVETKAD 964

  Fly  1012 KQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKF 1076
            ....|:...| |.|::..::||||||||:||||::|...|..||||:|||:||.||.||:|.|.|
  Rat   965 SIVRQKPVDL-LRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALF 1028

  Fly  1077 RNNGQCGYILKPSFMKSDSFNPNNPLCDGLSEVKVSIRLIAARHLFRGGKS-NNPQIVVELIGAS 1140
            ..||:.||:|:|..|:|:.::|..|.......:.::::::.||||.:.|:| ..|.:.||:.||.
  Rat  1029 SLNGRTGYVLQPESMRSEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAE 1093

  Fly  1141 FDTGVKYRTKVNENGFNPVW---NESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCI 1202
            :|:.....|.||:||.:|||   .|...|.:.:|..|.|||.|.:||||::.:|:|.|.||:..|
  Rat  1094 YDSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFLVYEEDMFSDPNFLAHATYPIKGI 1158

  Fly  1203 RQGYRSVILRNKFSEELELSSLLI 1226
            :.|:|||.|:|.:||::||:|||:
  Rat  1159 KSGFRSVPLKNGYSEDIELASLLV 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	41/124 (33%)
		PI-PLCc_gamma	323..>470	CDD:176534	98/147 (67%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	54/100 (54%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	39/101 (39%)
		SH3_PLCgamma	828..880	CDD:212759	26/51 (51%)
		PLCYc	981..1091	CDD:128454	53/112 (47%)
		C2_PLC_like	1109..1215	CDD:175974	44/109 (40%)
Plcg2	NP_058864.1	PH_PLC_gamma	22..140	CDD:270168	41/124 (33%)
		PH-like	235..>276	CDD:302622	8/42 (19%)
		PI-PLCc_gamma	311..>458	CDD:176534	98/146 (67%)
		PH-like	475..>510	CDD:302622	9/36 (25%)
		SH2_N-SH2_PLC_gamma_like	527..627	CDD:199829	54/100 (54%)
		SH2_C-SH2_PLC_gamma_like	641..744	CDD:198186	39/103 (38%)
		SH3_PLCgamma2	773..827	CDD:212902	27/55 (49%)
		PHsplit_PLC_gamma	<840..910	CDD:270054	15/73 (21%)
		PI-PLCc_GDPD_SF	<926..1031	CDD:301322	49/105 (47%)
		C2_PLC_like	1061..1187	CDD:175974	51/122 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345392
Domainoid	1	1.000	225	1.000	Domainoid score	I2449
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	922	1.000	Inparanoid score	I338
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0003159
OrthoInspector	1	1.000	-	-		otm45622
orthoMCL	1	0.900	-	-		OOG6_104615
Panther	1	1.100	-	-	O	PTHR10336
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X101
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900