DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sl and Plch2

DIOPT Version :9

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:XP_011248570.1 Gene:Plch2 / 269615 MGIID:2443078 Length:1759 Species:Mus musculus


Alignment Length:1269 Identity:313/1269 - (24%)
Similarity:504/1269 - (39%) Gaps:447/1269 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 MEQTIGMLERGTIVTKLYGKQRRPDRRHLMLIR-----ETRQLL-WATVATQTPRTDYEGAIQLR 73
            ||:.:..::.||.:.||.|..:.       |:|     |.|..| |     :..|.:.:..|.:.
Mouse   186 MERCMSAMQEGTQMVKLRGSSKG-------LVRFYYLDEHRSCLRW-----RPSRKNEKAKISID 238

  Fly    74 EIREIRVGKHSKEFRLFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMV- 137
            .|:|:..|:.|:.|:.:.|  ..|:.:.||.|.||:|  .:|..:|:.|..||..||.||||:: 
Mouse   239 SIQEVSEGRQSEIFQRYPD--SSFDPNCCFSIYHGSH--RESLDLVSPSSEEARTWVTGLRYLMA 299

  Fly   138 ----KDTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGK 198
                :|:|......: |:||::.:          .:|.:.....::|.:....|..::..:...:
Mouse   300 GISDEDSLARRQRTR-DQWLKQTF----------DEADKNGDGSLSISEVLQLLHKLNVNLPRQR 353

  Fly   199 FMEHFTEDVRRKHD--LKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQFL 261
            ..:.|.|.....|.  |.|::|...|:.:       |......:....||..:..:..::|::||
Mouse   354 VKQMFREADTDDHQGTLGFEEFCAFYKMM-------STRRDLYLLMLTYSNHKDHLDASDLQRFL 411

  Fly   262 ETEQRDVSASEISSAAIASFIRDFVQDVER---------------DVQEPYLTFP----EFVDFL 307
            |.||:   .:.::..:..:.|..|...:|.               .|.|.:...|    .|.::.
Mouse   412 EVEQK---MNGVTLESCQNIIEQFEPCLENKSKGMLGIDGSREPSPVMEIHHGAPVYTAGFTNYT 473

  Fly   308 FSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDC 372
            .|...|::|.::::|..||..|||.|:|.|||||||.|||..|:|..:.||..|:.||||:|:||
Mouse   474 RSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDC 538

  Fly   373 WNGPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVF 437
            |:|||..|.:.||:|:||||.|.|||:||..:||..:|||||||||.:||:.||:.|||.|.::.
Mouse   539 WDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDIL 603

  Fly   438 GDML-LTQPCDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHG 501
            ||.| |:.....:...||||..|:.||::|.||||                              
Mouse   604 GDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLP------------------------------ 638

  Fly   502 ENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSL 566
                .|:.:..:||                            |:::..:.:..:||      |.|
Mouse   639 ----ANISEDAEEG----------------------------EVSDEDSADEMEDD------CKL 665

  Fly   567 NSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLS 631
            .:.      |.|.|                 ||..:::.||                        
Mouse   666 LNG------DASTN-----------------RKRVENIAKK------------------------ 683

  Fly   632 FWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKH 696
                        ||                 |||                    :||        
Mouse   684 ------------KL-----------------DSL--------------------IKE-------- 691

  Fly   697 EDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDT 761
                                                          .||:.|   ::...:.:.|
Mouse   692 ----------------------------------------------SKIRDC---EDPNDFSVST 707

  Fly   762 MNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEEN 826
            ::                         .|.:|.|:|.|:..|                 |.:||:
Mouse   708 LS-------------------------PSGKLGRKAEAKKGQ-----------------SKVEED 730

  Fly   827 VTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNS 891
            |        :|.:.           :.|.|.||..::..:....||   .:.:|.:.|..|...:
Mouse   731 V--------EAGED-----------SGVSRQNSRLFMSSFSKRKKK---GSKIKKVASVEEGDET 773

  Fly   892 LNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEA 956
            |:..|:..|                                                        
Mouse   774 LDSPGSQSR-------------------------------------------------------- 782

  Fly   957 ALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFRE------HSWIFQEMSSFPETKAEKQFF 1015
                   .:.|:||  |.::::.:|||:.|.:||...:      .||   ::|||.||||. |..
Mouse   783 -------GTARQKK--TMKLSRALSDLVKYTKSVGTHDVEIEVVSSW---QVSSFSETKAH-QIL 834

  Fly  1016 QQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNG 1080
            ||....:|.::::|:||:||...|:||||:||.||||.|.||:|||||:..:.:|||:|||..||
Mouse   835 QQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANG 899

  Fly  1081 QCGYILKPSFMKSDSFNPN--NPLCDGLSEVKVSIRLIAARHLFR--------GGKSNNPQIVVE 1135
            .|||:|||..|....||||  :|| .|..:.::::|:|:.:.|.:        .|:..:|.:.||
Mouse   900 DCGYVLKPQCMCQGVFNPNSEDPL-PGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVE 963

  Fly  1136 LIGASFDTGVKYRTKVNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLT 1200
            :||...|...:....|::|||||:|.|:..|.|..|:.|::||.|.|.|.... .||.|.....:
Mouse   964 VIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGR-DFIGQRTLAFS 1027

  Fly  1201 CIRQGYRSVILRNKFSEELELSSLLINIKIANVT 1234
            .|..|||.|.|     |.:|.:|:.:::.:::::
Mouse  1028 SIMPGYRHVYL-----EGMEEASIFVHVAVSDIS 1056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 39/135 (29%)
PI-PLCc_gamma 323..>470 CDD:176534 79/147 (54%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 9/97 (9%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 6/99 (6%)
SH3_PLCgamma 828..880 CDD:212759 7/51 (14%)
PLCYc 981..1091 CDD:128454 57/115 (50%)
C2_PLC_like 1109..1215 CDD:175974 36/113 (32%)
Plch2XP_011248570.1 PH_PLC_eta 193..299 CDD:270170 37/121 (31%)
EFh_PI-PLC 317..477 CDD:333715 29/179 (16%)
EF-hand motif 317..346 CDD:320029 5/38 (13%)
EF-hand motif 353..383 CDD:320029 7/36 (19%)
EF-hand motif 387..415 CDD:320029 6/27 (22%)
EF-hand motif 424..477 CDD:320029 8/52 (15%)
PLN02228 459..1038 CDD:177873 241/934 (26%)
PI-PLCc_eta2 489..898 CDD:176570 184/762 (24%)
PHA03247 <1087..1579 CDD:223021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841985
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X101
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.750

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