Protein Alignment sl and Plch2

DIOPT Version :10

• Sequence 1: NP_476726.2
• Gene: sl / 32601
• FlyBaseID: FBgn0003416
• Length: 1236
• Species: Drosophila melanogaster
• Sequence 2: XP_011248570.1
• Gene: Plch2 / 269615
• MGIID: 2443078
• Length: 1759
• Species: Mus musculus
• Alignment Length: 1269
• Identity: 313/1269 - (24%)
• Similarity: 504/1269 - (39%)
• Gaps: 447/1269 - (35%)

  Fly    15 MEQTIGMLERGTIVTKLYGKQRRPDRRHLMLIR-----ETRQLL-WATVATQTPRTDYEGAIQLR 73
            ||:.:..::.||.:.||.|..:.       |:|     |.|..| |     :..|.:.:..|.:.
Mouse   186 MERCMSAMQEGTQMVKLRGSSKG-------LVRFYYLDEHRSCLRW-----RPSRKNEKAKISID 238

  Fly    74 EIREIRVGKHSKEFRLFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMV- 137
            .|:|:..|:.|:.|:.:.|  ..|:.:.||.|.||:|  .:|..:|:.|..||..||.||||::
Mouse   239 SIQEVSEGRQSEIFQRYPD--SSFDPNCCFSIYHGSH--RESLDLVSPSSEEARTWVTGLRYLMA 299

  Fly   138 ----KDTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGK 198
                :|:|......: |:||::.:          .:|.:.....::|.:....|..::..:...:
Mouse   300 GISDEDSLARRQRTR-DQWLKQTF----------DEADKNGDGSLSISEVLQLLHKLNVNLPRQR 353

  Fly   199 FMEHFTEDVRRKHD--LKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQFL 261
            ..:.|.|.....|.  |.|::|...|:.:       |......:....||..:..:..::|::||
Mouse   354 VKQMFREADTDDHQGTLGFEEFCAFYKMM-------STRRDLYLLMLTYSNHKDHLDASDLQRFL 411

  Fly   262 ETEQRDVSASEISSAAIASFIRDFVQDVER---------------DVQEPYLTFP----EFVDFL 307
            |.||:   .:.::..:..:.|..|...:|.               .|.|.:...|    .|.::.
Mouse   412 EVEQK---MNGVTLESCQNIIEQFEPCLENKSKGMLGIDGSREPSPVMEIHHGAPVYTAGFTNYT 473

  Fly   308 FSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDC 372
            .|...|::|.::::|..||..|||.|:|.|||||||.|||..|:|..:.||..|:.||||:|:||
Mouse   474 RSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDC 538

  Fly   373 WNGPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVF 437
            |:|||..|.:.||:|:||||.|.|||:||..:||..:|||||||||.:||:.||:.|||.|.::.
Mouse   539 WDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDIL 603

  Fly   438 GDML-LTQPCDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHG 501
            ||.| |:.....:...||||..|:.||::|.||||
Mouse   604 GDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLP------------------------------ 638

  Fly   502 ENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSL 566
                .|:.:..:||                            |:::..:.:..:||      |.|
Mouse   639 ----ANISEDAEEG----------------------------EVSDEDSADEMEDD------CKL 665

  Fly   567 NSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLS 631
            .:.      |.|.|                 ||..:::.||
Mouse   666 LNG------DASTN-----------------RKRVENIAKK------------------------ 683

  Fly   632 FWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKH 696
                        ||                 |||                    :||
Mouse   684 ------------KL-----------------DSL--------------------IKE-------- 691

  Fly   697 EDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDT 761
                                                          .||:.|   ::...:.:.|
Mouse   692 ----------------------------------------------SKIRDC---EDPNDFSVST 707

  Fly   762 MNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEEN 826
            ::                         .|.:|.|:|.|:..|                 |.:||:
Mouse   708 LS-------------------------PSGKLGRKAEAKKGQ-----------------SKVEED 730

  Fly   827 VTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNS 891
            |        :|.:.           :.|.|.||..::..:....||   .:.:|.:.|..|...:
Mouse   731 V--------EAGED-----------SGVSRQNSRLFMSSFSKRKKK---GSKIKKVASVEEGDET 773

  Fly   892 LNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEA 956
            |:..|:..|
Mouse   774 LDSPGSQSR-------------------------------------------------------- 782

  Fly   957 ALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFRE------HSWIFQEMSSFPETKAEKQFF 1015
                   .:.|:||  |.::::.:|||:.|.:||...:      .||   ::|||.||||. |..
Mouse   783 -------GTARQKK--TMKLSRALSDLVKYTKSVGTHDVEIEVVSSW---QVSSFSETKAH-QIL 834

  Fly  1016 QQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNG 1080
            ||....:|.::::|:||:||...|:||||:||.||||.|.||:|||||:..:.:|||:|||..||
Mouse   835 QQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANG 899

  Fly  1081 QCGYILKPSFMKSDSFNPN--NPLCDGLSEVKVSIRLIAARHLFR--------GGKSNNPQIVVE 1135
            .|||:|||..|....||||  :|| .|..:.::::|:|:.:.|.:        .|:..:|.:.||
Mouse   900 DCGYVLKPQCMCQGVFNPNSEDPL-PGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVE 963

  Fly  1136 LIGASFDTGVKYRTKVNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLT 1200
            :||...|...:....|::|||||:|.|:..|.|..|:.|::||.|.|.|.... .||.|.....:
Mouse   964 VIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGR-DFIGQRTLAFS 1027

  Fly  1201 CIRQGYRSVILRNKFSEELELSSLLINIKIANVT 1234
            .|..|||.|.|     |.:|.:|:.:::.:::::
Mouse  1028 SIMPGYRHVYL-----EGMEEASIFVHVAVSDIS 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	39/135 (29%)
		EFh_PI-PLCgamma	152..311	CDD:320031	29/179 (16%)
		EF-hand motif	152..191	CDD:320031	5/38 (13%)
		EF-hand motif	198..226	CDD:320031	7/29 (24%)
		EF-hand motif	230..265	CDD:320031	7/34 (21%)
		EF-hand motif	277..311	CDD:320031	8/52 (15%)
		PI-PLCc_gamma	323..>470	CDD:176534	79/147 (54%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	9/97 (9%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	6/99 (6%)
		SH3_PLCgamma	828..880	CDD:212759	7/51 (14%)
		PLCYc	981..1091	CDD:128454	57/115 (50%)
		C2_PLC_like	1109..1215	CDD:175974	36/113 (32%)
Plch2	XP_011248570.1	PH_PLC_eta	193..299	CDD:270170	37/121 (31%)
		EFh_PI-PLC	317..477	CDD:333715	29/179 (16%)
		EF-hand motif	317..346	CDD:320029	5/38 (13%)
		EF-hand motif	353..382	CDD:320029	7/28 (25%)
		EF-hand motif	387..415	CDD:320029	6/27 (22%)
		EF-hand motif	424..477	CDD:320029	8/52 (15%)
		PLN02228	459..1038	CDD:177873	241/934 (26%)
		PI-PLCc_eta2	489..898	CDD:176570	184/762 (24%)
		PHA03247	<1087..1579	CDD:223021