DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and Plcg2

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	NP_758489.1	Gene:	Plcg2 / 234779	MGIID:	97616	Length:	1265	Species:	Mus musculus

Alignment Length:	1263	Identity:	473/1263 - (37%)
Similarity:	719/1263 - (56%)	Gaps:	144/1263 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EMEQTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLLWATVATQTPRTDYEGAIQLREIREI 78
            |..|....||.||::|....::..|:||.:.:|.||||:.|:..|.:     .||.:.:.||:||
Mouse    14 EKSQIKRALELGTVMTVFNARKSTPERRTVQMIMETRQVAWSKTADK-----IEGFLDIMEIKEI 73

  Fly    79 RVGKHSKEFRLFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMVKDTLGA 143
            |.||:||:|.  .....|.::..||.||:|..|.|.:.|:...|:.:|..|:.||:.:.::.:.|
Mouse    74 RPGKNSKDFE--RAKAVRHKAECCFTILYGTQFVLSTLSLATDSKEDAVKWLSGLKILHQEAMSA 136

  Fly   144 PYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGKFM-EHFTEDV 207
            ..|..|:.|||::.|.::....:|          :::::.|..|..|:.|::..||: :...|..
Mouse   137 STPTMIESWLRKQIYSVDQTRRNS----------ISLRELKTILPLVNFKVSGIKFLKDKLVEIG 191

  Fly   208 RRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVV------RP-------AELKQ 259
            .:|.:|.|:.|...|:||:.... .|:|.       .:.:|..|.      ||       .:.::
Mouse   192 AQKDELSFEQFHLFYKKLMFDQQ-KSILD-------EFKKDSSVFILGNTDRPDASAVYLQDFQR 248

  Fly   260 FLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFM 324
            ||..||:::.|.:::.  :...:..|:.|..|:..||:|...||:.:|||::|.:|:.|||.|.|
Mouse   249 FLLHEQQELWAQDLNK--VRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDM 311

  Fly   325 -DMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFHGHTI 388
             |||.|||.|||:|||||||||||..||||.|||.|.||.||||||||||:|||..|.|:||.|.
Mouse   312 QDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDCWDGPDGKPIIYHGWTR 376

  Fly   389 TSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRNEQHL 453
            |:||||.||::.|:||||.:|.:|||||||::||:||||:||:...||.||||||:|.:.:...|
Mouse   377 TTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKVFKEVLGDMLLTKPTEASADQL 441

  Fly   454 PSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGLLY 518
            |||.|||.|||:|||||....|:...:                      .|.::..|  .:|.||
Mouse   442 PSPSQLREKIIIKHKKLGPKGDVDVNV----------------------EDKKDEHK--PQGELY 482

  Fly   519 FKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSANDEL 583
            ..|.:|:.|..:...:...:|.:..:|.::                     ::::....:...||
Mouse   483 MWDSIDQKWTRHYCAIADAKLSFGDDIEQA---------------------VEEEPVQDTPPTEL 526

  Fly   584 HFGENWFHGKLEGGRKEADDLLKKY-KHFG--DGTFLVRESATFVGDYSLSFWRRNRPNHCRIKL 645
            ||||.|||.|:| .|..|:.||::| ...|  |||||||||.||..||:|||||..|..||||:.
Mouse   527 HFGEKWFHKKVE-SRTSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRS 590

  Fly   646 KHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQ 710
            ..|||.:||||.:|..|:|:|:||.:||:..||.:||.:.|.:|||.|..||.:.|::.:.::.:
Mouse   591 TMENGVMKYYLTDNLTFNSIYALIQHYREAHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGE 655

  Fly   711 AEQGLYRL-EIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDT-MNFESLVSLINY 773
            ||..|.|: ..|:||:|.. :..|::.|:|....|:|||||.::||.:.:.| ..|||||.|::|
Mouse   656 AEDMLMRIPRDGAFLIRKR-EGTNSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSY 719

  Fly   774 YTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNG----ASNYMG-SNLEENV---TCK 830
            |.::.|||.::|.:||:.|||.:...|         .|.|.    :..|:. |.:..::   |.|
Mouse   720 YEKHALYRKMRLRYPVTPELLERYNME---------RDINSLYDVSRMYVDPSEINPSMPQRTVK 775

  Fly   831 ALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEE 895
            |||.|||.:.|||:|.:.|:|.||.::...||.||||..|:::.|:|||:  |.:..|...:.::
Mouse   776 ALYDYKAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVE--DISAGDAEEMEKQ 838

  Fly   896 GTD---------GRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQN--PFVIGFDNQETAYEW 949
            ..:         |..| :..:..|.:....|....:|.|:   |..|.  |.....|..|..:||
Mouse   839 IIEDNPLGSLCKGILD-LNTYNVVKAPQGKNQKAFVFILE---PKKQGDPPVEFATDRVEELFEW 899

  Fly   950 IKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFR-SVPFREH--SWIFQEMSSFPETKAE 1011
            .::|:|.........:..:..||...:|.|:|||::|.: :...::|  :..|:|:.||.||||:
Mouse   900 FQSIREITWKMDTKENNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVETKAD 964

  Fly  1012 KQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKF 1076
            ....|:...| |.|::..::||||||||:||||::|...|..||||:|||:||.||.||:|.|.|
Mouse   965 SIVRQKPVDL-LRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALF 1028

  Fly  1077 RNNGQCGYILKPSFMKSDSFNPNNPLCDGLSEVKV----SIRLIAARHLFRGGKS-NNPQIVVEL 1136
            ..||:.||:|:|..|:|:.::| .||   .|:.|:    :::::.||||.:.|:| ..|.:.||:
Mouse  1029 SLNGRTGYVLQPESMRSEKYDP-MPL---ESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEI 1089

  Fly  1137 IGASFDTGVKYRTKVNENGFNPVW---NESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYP 1198
            .||.:|:.....|.||:||.:|||   .|...|.:.:|..|.|||.|.:||||::.:|:|.|.||
Mouse  1090 CGAEYDSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYP 1154

  Fly  1199 LTCIRQGYRSVILRNKFSEELELSSLLI 1226
            :..|:.|:|||.|:|.:||::||:|||:
Mouse  1155 IKGIKSGFRSVPLKNGYSEDIELASLLV 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	42/124 (34%)
		PI-PLCc_gamma	323..>470	CDD:176534	99/147 (67%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	55/100 (55%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	40/101 (40%)
		SH3_PLCgamma	828..880	CDD:212759	26/51 (51%)
		PLCYc	981..1091	CDD:128454	53/112 (47%)
		C2_PLC_like	1109..1215	CDD:175974	45/113 (40%)
Plcg2	NP_758489.1	PH_PLC_gamma	22..140	CDD:270168	42/124 (34%)
		PH-like	235..>276	CDD:302622	8/42 (19%)
		PI-PLCc_gamma	311..>458	CDD:176534	99/146 (68%)
		PH-like	475..>512	CDD:302622	9/38 (24%)
		SH2_N-SH2_PLC_gamma_like	527..627	CDD:199829	55/100 (55%)
		SH2_C-SH2_PLC_gamma_like	641..744	CDD:198186	40/103 (39%)
		SH3_PLCgamma2	773..827	CDD:212902	27/55 (49%)
		PHsplit_PLC_gamma	<840..909	CDD:270054	15/72 (21%)
		PI-PLCc_GDPD_SF	<926..1031	CDD:301322	49/105 (47%)
		C2_PLC_like	1061..1187	CDD:175974	51/122 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841997
Domainoid	1	1.000	226	1.000	Domainoid score	I2507
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	923	1.000	Inparanoid score	I354
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0003159
OrthoInspector	1	1.000	-	-		otm43555
orthoMCL	1	0.900	-	-		OOG6_104615
Panther	1	1.100	-	-	O	PTHR10336
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760