DRSC/TRiP Functional Genomics Resources

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Protein Alignment sl and PLCB1

DIOPT Version :10

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_056007.1 Gene:PLCB1 / 23236 HGNCID:15917 Length:1216 Species:Homo sapiens


Alignment Length:1242 Identity:254/1242 - (20%)
Similarity:407/1242 - (32%) Gaps:524/1242 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 LIRETRQLLWATVAT-QTP---RTDYEG-------------AIQLREIREIRVGKHSK-----EF 87
            |.:.|:.:.|...:| .||   |||.:|             .:.|..:::.|.|:|:|     :.
Human    22 LKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKL 86

  Fly    88 RLFAD--DCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMVKDTLGAPYPLQID 150
            |...|  :..|.|.....|:...:...:...::||..|..|..|...:..:..:.|.  ..:..|
Human    87 RELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLA--QNMSRD 149

  Fly   151 RWLRREYYQIENVNTHSAKATEQSPAQVTIKD-FKLFLAG--------VSCKMTTGKF----MEH 202
            .:|.:.|.::        |.......::.:|: ::||.|.        .:|.:.:.:.    .|.
Human   150 AFLEKAYTKL--------KLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQED 206

  Fly   203 FTEDVRRKHDLKFDDFSRLYQKLLLPN-GFASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQR 266
            ||.:|           .|::...|.|. ...::.|..|..:.||....|::      .|:..:||
Human   207 FTPEV-----------YRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMM------DFINLKQR 254

  Fly   267 DVSASEISSAAI-ASFIRDFVQDVERD---VQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMN 327
            |...:||....: ...::..::..|.:   .::..::...|:.:|..::|.:.:.:...:..||:
Human   255 DPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMS 319

  Fly   328 LPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNG--PDNLPYIFHGHTITS 390
            .|||.|:|.||||||||..|.:..||.|.|.:.|..||||:|||||.|  .:..|.|.||.|:|:
Human   320 QPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTT 384

  Fly   391 KIKFMDVIKTIKDHAFTSSEYPVILSIEQNC-SLEQQRNMAQALIEVFGDMLLTQPCDR----NE 450
            :|.|.:||:.|.:.||.:|.:|::||.|.:. |.:||..||:....:|||.||.:|.::    :.
Human   385 EISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESG 449

  Fly   451 QHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEG 515
            ..||||..|..||::|:||                ..|:||            :|...:|:.::.
Human   450 VPLPSPMDLMYKILVKNKK----------------KSHKSS------------EGSGKKKLSEQA 486

  Fly   516 LLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSAN 580
            ...:.|.                   ||....|..|..|                    .||.::
Human   487 SNTYSDS-------------------SSMFEPSSPGAGE--------------------ADTESD 512

  Fly   581 DELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKL 645
            |:                 :.||..||                                      
Human   513 DD-----------------DDDDDCKK-------------------------------------- 522

  Fly   646 KHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQ 710
                                             ||                              
Human   523 ---------------------------------SS------------------------------ 524

  Fly   711 AEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYT 775
                                                    |.||.. |.:.|..|.:.:|:||. 
Human   525 ----------------------------------------MDEGTA-GSEAMATEEMSNLVNYI- 547

  Fly   776 RNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKP 840
                       .||..|                                         |::.:|.
Human   548 -----------QPVKFE-----------------------------------------SFEISKK 560

  Fly   841 DELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIE 905
            ...||                                                            
Human   561 RNKSF------------------------------------------------------------ 565

  Fly   906 IFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKK 970
                                                                             
Human   566 ----------------------------------------------------------------- 565

  Fly   971 ERTARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYP 1035
                                          |||||.|||..:|..:...: |:.|::.|:||:||
Human   566 ------------------------------EMSSFVETKGLEQLTKSPVE-FVEYNKMQLSRIYP 599

  Fly  1036 KGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMK--SDSFNP 1098
            ||.|:||||:.|..|||.|.||:|||:||.|.|||:|...:..||:.||.|||.||:  ...|:|
Human   600 KGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDP 664

  Fly  1099 -NNPLCDGLSEVKVSIRLIAARHLFRGGKSNNPQIVVELIGASFDTGVK-YRTKVNE-NGFNPVW 1160
             ...:.||:....:|:::|:.:  |...|.....:.|::.|...||..| ::||.:: |..||||
Human   665 FTEGIVDGIVANTLSVKIISGQ--FLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVW 727

  Fly  1161 NES-CEF-NVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSS 1223
            .|. ..| .|..|..|.||..|.:|.    ..||.....|:..||.||..:.|||:.::.|.|.:
Human   728 EEEPIVFKKVVLPTLACLRIAVYEEG----GKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788

  Fly  1224 LLINIKI 1230
            :.:.|::
Human   789 VFVYIEV 795

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 26/125 (21%)
EFh_PI-PLCgamma 152..311 CDD:320031 29/176 (16%)
EF-hand motif 152..191 CDD:320031 7/47 (15%)
EF-hand motif 198..226 CDD:320031 5/31 (16%)
EF-hand motif 230..265 CDD:320031 6/34 (18%)
EF-hand motif 277..311 CDD:320031 3/37 (8%)
PI-PLCc_gamma 323..>470 CDD:176534 69/153 (45%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 6/97 (6%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 12/99 (12%)
SH3_PLCgamma 828..880 CDD:212759 4/51 (8%)
PLCYc 981..1091 CDD:128454 47/109 (43%)
C2_PLC_like 1109..1215 CDD:175974 35/109 (32%)
PLCB1NP_056007.1 PH_PLC_beta 22..148 CDD:270167 26/127 (20%)
EFh_PI-PLCbeta1 153..303 CDD:320038 28/174 (16%)
EF-hand motif 153..182 CDD:320038 6/36 (17%)
EF-hand motif 186..215 CDD:320038 6/39 (15%)
EF-hand motif 224..253 CDD:320038 6/34 (18%)
EF-hand motif 270..303 CDD:320038 3/32 (9%)
PI-PLCc_beta 316..643 CDD:176533 146/761 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 469..534 24/274 (9%)
C2_PLC_like 677..796 CDD:175974 38/125 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 834..891
DUF1154 903..939 CDD:461969
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 963..994
PLC-beta_C 1003..1170 CDD:462571
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1071..1095
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1173..1216
Blue background indicates that the domain is not in the aligned region.

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