DRSC/TRiP Functional Genomics Resources

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Protein Alignment sl and Plcl1

DIOPT Version :9

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_001108135.1 Gene:Plcl1 / 227120 MGIID:3036262 Length:1096 Species:Mus musculus


Alignment Length:1274 Identity:262/1274 - (20%)
Similarity:422/1274 - (33%) Gaps:565/1274 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 FSAM-SAPLLGEMEQTIGMLERGTIVTKLYGKQRRPD----RRHLMLIRETRQLLWATVATQTPR 63
            ||:| |...:......|..::.|..:.|:     ||:    .|...|..:.:.|.|     :..:
Mouse    97 FSSMPSEKKISSAHDCISFMQAGCELKKV-----RPNSRIYNRFFTLDTDLQALRW-----EPSK 151

  Fly    64 TDYEGA-IQLREIREIRVGKHSKEFR------LFADDCQRFESSKCFVILHGNHFKLKSFSVVAL 121
            .|.|.| :.:..|:|||:||:::.||      ...:||       .|.||||.::  :|..:||.
Mouse   152 KDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDC-------AFSILHGENY--ESLDLVAN 207

  Fly   122 SEIEADNWVRGLRYMVKDTLGAPYPLQIDR---------WLRREY---------YQIENVNTHSA 168
            |...|:.||.||||:|.   .:..||....         ||:..:         ..:|:.:....
Mouse   208 SADVANIWVSGLRYLVS---RSKQPLDFIEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELI 269

  Fly   169 K----ATEQSPAQVTIKDFKLFLAGVSCKMTTGKFMEHFTEDVRRKHDLKFDDFSRLYQKLLLPN 229
            |    ..::|..::..|:.:.....::.::|..:|.|.|.|...|         ..:|..|:   
Mouse   270 KQLNPTLKESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTR---------PEVYFLLV--- 322

  Fly   230 GFASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERD-V 293
                          ..|::::.:...:|..|||.||   ..:.|:.......||.:  ::..| .
Mouse   323 --------------QISKNKEYLDANDLMLFLEAEQ---GVTHITEDMCLDIIRRY--ELSEDGR 368

  Fly   294 QEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYA 358
            |:.:|....|..:|.|.:.|:::.:..:|..||..|||.|:|.:||||||..|||...:....|.
Mouse   369 QKGFLAIDGFTQYLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYV 433

  Fly   359 RALRMGCRCIELDCWNGPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSL 423
            |||:||||.||||..:||||.|.:.:.:.:...:.|..|::.|...||.:||||:||.:..:|||
Mouse   434 RALKMGCRSIELDVSDGPDNEPILCNRNNMAMHLSFRSVLEVINKFAFVASEYPLILCLGNHCSL 498

  Fly   424 EQQRNMAQALIEVFGDMLLTQPCDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGH 488
            .||:.|||.:.:|||:.|.|:....:|.:||||.:|:..||:|.||||...|:..|         
Mouse   499 PQQKVMAQQMKKVFGEKLYTEAPLSSESYLPSPEKLKNMIIVKGKKLPSESDLLEG--------- 554

  Fly   489 RSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNS 553
                                                                   |:.:      
Mouse   555 -------------------------------------------------------EVTD------ 558

  Fly   554 EDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLV 618
            ||::..:|...|                                                     
Mouse   559 EDEEAEMSRRMS----------------------------------------------------- 570

  Fly   619 RESATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFS 683
                   |||                    ||..|:.                            
Mouse   571 -------GDY--------------------NGEQKHI---------------------------- 580

  Fly   684 IILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHC 748
                             |.                                             |
Mouse   581 -----------------WL---------------------------------------------C 583

  Fly   749 RIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDN 813
            |.:.:             |||:                                           
Mouse   584 RELSD-------------LVSI------------------------------------------- 592

  Fly   814 GASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANY 878
                           ||::              :|       ||                     
Mouse   593 ---------------CKSV--------------QH-------RD--------------------- 600

  Fly   879 VKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQ 943
                                                        |:|.::|   ||         
Mouse   601 --------------------------------------------FELSMKT---QN--------- 609

  Fly   944 ETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPET 1008
                                                                   :.||.||.||
Mouse   610 -------------------------------------------------------YWEMCSFSET 619

  Fly  1009 KAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQ 1073
            :|.: ...:..:.|::|::..:|||||...|:||||.||..|||.|.|::|:|:||....|.|:.
Mouse   620 EASR-IANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHT 683

  Fly  1074 AKFRNNGQCGYILKPSFMKSD--SFNPNNP-LCDGLSEVKVSIRLIAARHLFR------GGKSNN 1129
            ..|..||.|||:|:||.|:.:  .|:.|.. :..|:|.:.:.|::|:.::..:      .|...:
Mouse   684 GWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLVLHIKIISGQNFPKPKGACAKGDVID 748

  Fly  1130 PQIVVELIGASFDTGVKYRTK-VNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIA 1193
            |.:.||:.|...|. .:.||| |.:|..||:::|:.||.|..|:..::||.:.|:|...: .||.
Mouse   749 PYVCVEIHGIPADC-CEQRTKTVQQNSDNPIFDETFEFQVNLPELTMVRFVILDDDYIGD-EFIG 811

  Fly  1194 QACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKIAN 1232
            |...|..|::.|||.|.||:...:.:|..:|.::|.|.|
Mouse   812 QYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITN 850

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 38/135 (28%)
PI-PLCc_gamma 323..>470 CDD:176534 67/146 (46%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 6/97 (6%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 6/99 (6%)
SH3_PLCgamma 828..880 CDD:212759 5/51 (10%)
PLCYc 981..1091 CDD:128454 41/109 (38%)
C2_PLC_like 1109..1215 CDD:175974 35/112 (31%)
Plcl1NP_001108135.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..101 2/3 (67%)
Interaction with PPP1C. /evidence=ECO:0000250 83..222 41/143 (29%)
PH_PLC_eta 116..224 CDD:270170 37/126 (29%)
PH 119..224 CDD:278594 37/123 (30%)
EF-hand_like 316..397 CDD:286375 19/102 (19%)
PLN02228 331..851 CDD:177873 202/992 (20%)
PI-PLCc_PRIP_metazoa 399..689 CDD:176539 132/754 (18%)
Interaction with GABA A beta subunit. /evidence=ECO:0000250 544..568 9/93 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..569 6/88 (7%)
C2_PLC_like 721..849 CDD:175974 38/129 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1096
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841981
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R928
SonicParanoid 1 1.000 - - X101
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.780

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