DRSC/TRiP Functional Genomics Resources

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Protein Alignment sl and Plcl1

DIOPT Version :10

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_001108135.1 Gene:Plcl1 / 227120 MGIID:3036262 Length:1096 Species:Mus musculus


Alignment Length:1274 Identity:262/1274 - (20%)
Similarity:422/1274 - (33%) Gaps:565/1274 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 FSAM-SAPLLGEMEQTIGMLERGTIVTKLYGKQRRPD----RRHLMLIRETRQLLWATVATQTPR 63
            ||:| |...:......|..::.|..:.|:     ||:    .|...|..:.:.|.|     :..:
Mouse    97 FSSMPSEKKISSAHDCISFMQAGCELKKV-----RPNSRIYNRFFTLDTDLQALRW-----EPSK 151

  Fly    64 TDYEGA-IQLREIREIRVGKHSKEFR------LFADDCQRFESSKCFVILHGNHFKLKSFSVVAL 121
            .|.|.| :.:..|:|||:||:::.||      ...:||       .|.||||.::  :|..:||.
Mouse   152 KDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDC-------AFSILHGENY--ESLDLVAN 207

  Fly   122 SEIEADNWVRGLRYMVKDTLGAPYPLQIDR---------WLRREY---------YQIENVNTHSA 168
            |...|:.||.||||:|.   .:..||....         ||:..:         ..:|:.:....
Mouse   208 SADVANIWVSGLRYLVS---RSKQPLDFIEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELI 269

  Fly   169 K----ATEQSPAQVTIKDFKLFLAGVSCKMTTGKFMEHFTEDVRRKHDLKFDDFSRLYQKLLLPN 229
            |    ..::|..::..|:.:.....::.::|..:|.|.|.|...|         ..:|..|:   
Mouse   270 KQLNPTLKESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTR---------PEVYFLLV--- 322

  Fly   230 GFASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERD-V 293
                          ..|::::.:...:|..|||.||   ..:.|:.......||.:  ::..| .
Mouse   323 --------------QISKNKEYLDANDLMLFLEAEQ---GVTHITEDMCLDIIRRY--ELSEDGR 368

  Fly   294 QEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYA 358
            |:.:|....|..:|.|.:.|:::.:..:|..||..|||.|:|.:||||||..|||...:....|.
Mouse   369 QKGFLAIDGFTQYLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYV 433

  Fly   359 RALRMGCRCIELDCWNGPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSL 423
            |||:||||.||||..:||||.|.:.:.:.:...:.|..|::.|...||.:||||:||.:..:|||
Mouse   434 RALKMGCRSIELDVSDGPDNEPILCNRNNMAMHLSFRSVLEVINKFAFVASEYPLILCLGNHCSL 498

  Fly   424 EQQRNMAQALIEVFGDMLLTQPCDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGH 488
            .||:.|||.:.:|||:.|.|:....:|.:||||.:|:..||:|.||||...|:..|         
Mouse   499 PQQKVMAQQMKKVFGEKLYTEAPLSSESYLPSPEKLKNMIIVKGKKLPSESDLLEG--------- 554

  Fly   489 RSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNS 553
                                                                   |:.:      
Mouse   555 -------------------------------------------------------EVTD------ 558

  Fly   554 EDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLV 618
            ||::..:|...|                                                     
Mouse   559 EDEEAEMSRRMS----------------------------------------------------- 570

  Fly   619 RESATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFS 683
                   |||                    ||..|:.                            
Mouse   571 -------GDY--------------------NGEQKHI---------------------------- 580

  Fly   684 IILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHC 748
                             |.                                             |
Mouse   581 -----------------WL---------------------------------------------C 583

  Fly   749 RIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDN 813
            |.:.:             |||:                                           
Mouse   584 RELSD-------------LVSI------------------------------------------- 592

  Fly   814 GASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANY 878
                           ||::              :|       ||                     
Mouse   593 ---------------CKSV--------------QH-------RD--------------------- 600

  Fly   879 VKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQ 943
                                                        |:|.::|   ||         
Mouse   601 --------------------------------------------FELSMKT---QN--------- 609

  Fly   944 ETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPET 1008
                                                                   :.||.||.||
Mouse   610 -------------------------------------------------------YWEMCSFSET 619

  Fly  1009 KAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQ 1073
            :|.: ...:..:.|::|::..:|||||...|:||||.||..|||.|.|::|:|:||....|.|:.
Mouse   620 EASR-IANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHT 683

  Fly  1074 AKFRNNGQCGYILKPSFMKSD--SFNPNNP-LCDGLSEVKVSIRLIAARHLFR------GGKSNN 1129
            ..|..||.|||:|:||.|:.:  .|:.|.. :..|:|.:.:.|::|:.::..:      .|...:
Mouse   684 GWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLVLHIKIISGQNFPKPKGACAKGDVID 748

  Fly  1130 PQIVVELIGASFDTGVKYRTK-VNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIA 1193
            |.:.||:.|...|. .:.||| |.:|..||:::|:.||.|..|:..::||.:.|:|...: .||.
Mouse   749 PYVCVEIHGIPADC-CEQRTKTVQQNSDNPIFDETFEFQVNLPELTMVRFVILDDDYIGD-EFIG 811

  Fly  1194 QACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKIAN 1232
            |...|..|::.|||.|.||:...:.:|..:|.::|.|.|
Mouse   812 QYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITN 850

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 38/135 (28%)
EFh_PI-PLCgamma 152..311 CDD:320031 30/172 (17%)
EF-hand motif 152..191 CDD:320031 6/51 (12%)
EF-hand motif 198..226 CDD:320031 6/27 (22%)
EF-hand motif 230..265 CDD:320031 5/34 (15%)
EF-hand motif 277..311 CDD:320031 8/34 (24%)
PI-PLCc_gamma 323..>470 CDD:176534 67/146 (46%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 6/97 (6%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 6/99 (6%)
SH3_PLCgamma 828..880 CDD:212759 5/51 (10%)
PLCYc 981..1091 CDD:128454 41/109 (38%)
C2_PLC_like 1109..1215 CDD:175974 35/112 (31%)
Plcl1NP_001108135.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..101 2/3 (67%)
Interaction with PPP1C. /evidence=ECO:0000250 83..222 41/143 (29%)
PH_PLC_eta 116..224 CDD:270170 37/126 (29%)
EFh_PI-PLC 244..386 CDD:333715 30/172 (17%)
EF-hand motif 244..273 CDD:320029 4/28 (14%)
EF-hand motif 280..311 CDD:320029 5/30 (17%)
EF-hand motif 316..344 CDD:320029 7/44 (16%)
EF-hand motif 353..386 CDD:320029 8/34 (24%)
PI-PLCc_PRIP_metazoa 399..689 CDD:176539 132/754 (18%)
Interaction with GABA A beta subunit. /evidence=ECO:0000250 544..568 9/93 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..569 6/88 (7%)
C2_PLC_like 721..849 CDD:175974 38/129 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1096
Blue background indicates that the domain is not in the aligned region.

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