DRSC/TRiP Functional Genomics Resources

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Protein Alignment sl and Plcl2

DIOPT Version :9

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_038908.2 Gene:Plcl2 / 224860 MGIID:1352756 Length:1128 Species:Mus musculus


Alignment Length:1279 Identity:263/1279 - (20%)
Similarity:423/1279 - (33%) Gaps:570/1279 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 FSAM-SAPLLGEMEQTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLLWATVATQTPRTDYE 67
            ||:| :...:......|..:..|:.:.|:.... |...|:.:|..:.:.|.|     :..:.|.|
Mouse   125 FSSMPTEKKISSASDCINSMVEGSELKKVRSNS-RIYHRYFLLDADMQSLRW-----EPSKKDSE 183

  Fly    68 GA-IQLREIREIRVGKHSKEFR------LFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIE 125
            .| |.::.|:|:|.||::..||      ..::||       .|.:::|.::  :|..:||.|...
Mouse   184 KAKIDIKSIKEVRTGKNTDIFRSNGISEQISEDC-------AFSVIYGENY--ESLDLVANSADV 239

  Fly   126 ADNWVRGLRYMVK------DTLGAPYPLQIDRWLRREYYQIE-----------------NVNTHS 167
            |:.||.||||::.      |.|.:........|:.:.:.:|:                 |:|   
Mouse   240 ANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWISQMFSEIDVDGLGHITLCHAVQCIRNLN--- 301

  Fly   168 AKATEQSPAQVTIKDFKLFLAGVSCKMTTGKFMEHFTEDVRRKHDLKFDDFSRLYQKLLLPNGFA 232
             ...:.|..::..|:..........::|..:|:|.|.|...|         ..:|..|:      
Mouse   302 -PGLKTSKIELKFKELHKSKDKAGTEITKEEFIEVFHELCTR---------PEIYFLLV------ 350

  Fly   233 SVLSGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEP- 296
                       .:|.:::.:...:|..|||.||   ..:.|:.......|..:  :..::.||. 
Mouse   351 -----------QFSSNKEFLDTKDLMMFLEAEQ---GVAHINEEISLEIIHKY--EPSKEGQEKG 399

  Fly   297 YLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARAL 361
            :|:...|.::|.|....:::.::.:|..||..|||.|:|.|||||||..|||...|....|.|||
Mouse   400 WLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRAL 464

  Fly   362 RMGCRCIELDCWNGPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQ 426
            :||||.:|||.|:||||.|.|:.|||:||:|.|..||..|..:||.:||||:||.:|.:||::||
Mouse   465 KMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQ 529

  Fly   427 RNMAQALIEVFGDMLLTQPCDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSS 491
            :.|.|.:.::.||.|.|...:..|.:||||..|:.||::|.||                      
Mouse   530 KVMVQHMKKILGDKLYTTSPNMEESYLPSPDVLKGKILIKAKK---------------------- 572

  Fly   492 LGGAGGGAHGENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDD 556
                                                                             
Mouse   573 ----------------------------------------------------------------- 572

  Fly   557 DFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRES 621
               |||:||                                                        
Mouse   573 ---LSSNCS-------------------------------------------------------- 578

  Fly   622 ATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIIL 686
                                                                             
Mouse   579 ----------------------------------------------------------------- 578

  Fly   687 KEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIM 751
                                                                             
Mouse   579 ----------------------------------------------------------------- 578

  Fly   752 QEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGA- 815
                                                             ..:||.:  .:|.|| 
Mouse   579 -------------------------------------------------GVEGDVT--DEDEGAE 592

  Fly   816 -SNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYV 879
             |..||..                              ||::.|              |:|    
Mouse   593 MSQRMGKE------------------------------NVEQPN--------------HVP---- 609

  Fly   880 KVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQE 944
                                                                             
Mouse   610 ----------------------------------------------------------------- 609

  Fly   945 TAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFREHSWIFQ-----EMSS 1004
                 :|..|                     :.||:|:|:...:||.|:|....||     |:.|
Mouse   610 -----VKRFQ---------------------LCKELSELVSICKSVQFKEFQVSFQVQKYWEVCS 648

  Fly  1005 FPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAM 1069
            |.|..|.| :..:|...|::|::..::||:|...|:||||.||..||..|.|::|:|:||....|
Mouse   649 FNEVLASK-YANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMM 712

  Fly  1070 QLNQAKFRNNGQCGYILKPSFMKSD----SFNPNNPLCDGLSEVKVSIRLIAARHLFR----GGK 1126
            .||...||.||.|||:|:|:.|:.:    |.|..:.: .|:|...:.|::|:.::..:    |.|
Mouse   713 DLNVGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSV-PGVSPQLLHIKIISGQNFPKPKGSGAK 776

  Fly  1127 SN--NPQIVVELIGASFDTGVKYRTK-VNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAE 1188
            .:  :|.:.||:.|...|. .:.||| ||:||..|:::||.||.:..|:.|::||.|.|:|...:
Mouse   777 GDVVDPYVYVEIHGIPADC-AEQRTKTVNQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGD 840

  Fly  1189 THFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKIAN 1232
             .||.|...|..|::.|||.|.|::...|.|..:||.:::.|.|
Mouse   841 -EFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITN 883

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 35/137 (26%)
PI-PLCc_gamma 323..>470 CDD:176534 75/146 (51%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 0/97 (0%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 0/99 (0%)
SH3_PLCgamma 828..880 CDD:212759 5/51 (10%)
PLCYc 981..1091 CDD:128454 47/114 (41%)
C2_PLC_like 1109..1215 CDD:175974 38/112 (34%)
Plcl2NP_038908.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..129 2/3 (67%)
PH_PLC_eta 144..252 CDD:270170 33/122 (27%)
EFh_PRIP2 272..415 CDD:320053 29/177 (16%)
EF-hand motif 272..301 CDD:320053 3/28 (11%)
EF-hand motif 308..340 CDD:320053 6/31 (19%)
EF-hand motif 344..372 CDD:320053 7/44 (16%)
EF-hand motif 381..415 CDD:320053 7/35 (20%)
PI-PLCc_PRIP_metazoa 426..722 CDD:176539 138/762 (18%)
C2_PLC_like 754..882 CDD:175974 42/129 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1100..1128
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841995
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R928
SonicParanoid 1 1.000 - - X101
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.780

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