DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and Plcd4

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	XP_006495846.1	Gene:	Plcd4 / 18802	MGIID:	107469	Length:	833	Species:	Mus musculus

Alignment Length:	1272	Identity:	275/1272 - (21%)
Similarity:	440/1272 - (34%)	Gaps:	524/1272 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EQTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLLWATVATQTPRTDYEGAIQLREIREIRV 80
            :|.:.:::.||::.|:..|..: ..|:..|..:...:...:.....|:..:    .:.::..||.
Mouse    12 DQDLLLMQEGTMMRKVRTKSWK-KLRYFRLQNDGMTVWHGSQPESMPKPTF----SISDVERIRK 71

  Fly    81 GKHSKEFRLFADDCQRFESSKCF-VILHGNHFKLKSFSVVALSEIEADNWVRGLRYMVKDTLGAP 144
            |:.|:..|...::   |...:.| |:.||   :..:..:||.|..||..|:|||:.:|.......
Mouse    72 GQDSELLRYLVEE---FPLEQGFTVVFHG---RRPNLDLVANSVEEAQIWMRGLQLLVDLVASMD 130

  Fly   145 YPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGKFMEHFTE-DVR 208
            :..|:|:.| .|::|         :|......:::.::.:..|..::.:|........|.| ||.
Mouse   131 HQEQMDQML-NEWFQ---------QADRNQDGRMSFREAQRLLLLMNVEMDEEYAFSLFQEADVT 185

  Fly   209 RKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSASEI 273
            :..||..::|.:.|:.|........:..       .:|.|:|.:...|...||..||::
Mouse   186 QSDDLGSEEFVQFYKALTKRTEIEEIFE-------DFSSDKQKLTLLEFVDFLRKEQKE------ 237

  Fly   274 SSAAIASFIRDFVQDVERDVQEPY-----------LTFPEFVDFLFSKQNDLWNSKYDQVFMDMN 327
                     :|...|:..::.:.|           |:...|:.:|.||..:::||....::.||.
Mouse   238 ---------KDHAPDLALELIDRYEPSENGRLLHVLSKDGFLKYLCSKDGNIFNSDCLPIYQDMT 293

  Fly   328 LPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFHGHTITSKI 392
            .|||.|:|.|||||||.|||...:||.|.|.|||:.||||:|:|.|:|||..|.::||||:||:|
Mouse   294 QPLSHYYINSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDTWDGPDGEPVVYHGHTLTSRI 358

  Fly   393 KFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRNE------Q 451
            .|.||:.|:..:||.||:||:|||:|.:|:.||||.||..|.|:.|:.||     ||.      .
Mouse   359 LFKDVLATLAQYAFQSSDYPLILSLENHCTWEQQRTMAHHLTEILGEQLL-----RNTLEGLLVD 418

  Fly   452 HLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGL 516
            .:|||.|||.||::|.|||...:
Mouse   419 SMPSPEQLRGKILVKGKKLRTIE------------------------------------------ 441

  Fly   517 LYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSAND 581
                  |||                                               ::::....:
Mouse   442 ------VDK-----------------------------------------------EEEEEEEEE 453

  Fly   582 ELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLK 646
            ||.             :.|..||
Mouse   454 ELE-------------KDEGPDL------------------------------------------ 463

  Fly   647 HENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQA 711

Mouse   464 ----------------------------------------------------------------- 463

  Fly   712 EQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTR 776

Mouse   464 ----------------------------------------------------------------- 463

  Fly   777 NPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPD 841
                      .|.|.||..|...| .||..:|                         :.|..|..
Mouse   464 ----------DPASPELDTQPQPE-TQGQAAG-------------------------NKKERKKK 492

  Fly   842 ELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEI 906
            .:..|...::                                                      |
Mouse   493 VMKCPMSCLL------------------------------------------------------I 503

  Fly   907 FGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQ---LASERR 968
            .|.|.:               |.|:                    :|.|:.|::.|   |:|
Mouse   504 CGHVMA---------------QAPS--------------------SIPESILLSKQFLLLSS--- 530

  Fly   969 KKERTARVAKEMSDLIIYFRSVPF------REHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHR 1027
                |..:..::|.|::|.|:|||      :|:..|: ::|||.|:|| |...::....|:.::.
Mouse   531 ----TTIMCPDLSALVVYLRTVPFCSFTHSKENYHIY-DISSFSESKA-KNLIKEAGNEFVQHNA 589

  Fly  1028 NQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMK 1092
            .|:.||||.|.|.|||||||...||||.||:|:|.||...||.:....||.||..||:|||.|::
Mouse   590 RQLCRVYPSGLRTDSSNFNPQEHWNVGCQMVAMNMQTAGSAMDICDGLFRQNGGSGYVLKPEFLR 654

  Fly  1093 --SDSFNPNNPLCDGLSEVKVSIRLIAARHLFRGGKSN-----NPQIVVELIGASFDTGVKYRTK 1150
              ..||||..|:....:::.| :::|:.:.|.:..|:.     :|.:.|||.|...||..:..:.
Mouse   655 DTQSSFNPERPISLYKAQILV-VQVISGQQLPKVDKTKETTVVDPLVKVELYGVPEDTKEQETSH 718

  Fly  1151 VNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQ----------- 1204
            |..||.||.|.|:..|.::.|:.|:|||.|:|....:..:||.|...|.||::|
Mouse   719 VENNGINPYWGETFYFRLQVPELAMLRFVVKDYSRKSRNNFIGQYTLPWTCMKQGETNLGLLANI 783

  Fly  1205 ---------------GYRSVILRNKFSEELELSSLLI 1226
                           |||.|.|.::....|..:|:.:
Mouse   784 PTVAPFLIEFFCPFPGYRHVSLLSRDGTSLNPASIFV 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	27/125 (22%)
		PI-PLCc_gamma	323..>470	CDD:176534	80/152 (53%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	3/97 (3%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	4/99 (4%)
		SH3_PLCgamma	828..880	CDD:212759	3/51 (6%)
		PLCYc	981..1091	CDD:128454	52/115 (45%)
		C2_PLC_like	1109..1215	CDD:175974	38/136 (28%)
Plcd4	XP_006495846.1	PH_PLC_delta	18..133	CDD:270169	27/125 (22%)
		EF-hand_10	153..202	CDD:317225	10/48 (21%)
		PLN02228	207..773	CDD:177873	222/1007 (22%)
		PI-PLCc_GDPD_SF	289..641	CDD:387364	159/770 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841993
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R928
SonicParanoid	1	1.000	-	-		X101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.770