DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sl and Plcb3

DIOPT Version :9

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_001277278.1 Gene:Plcb3 / 18797 MGIID:104778 Length:1234 Species:Mus musculus


Alignment Length:1243 Identity:281/1243 - (22%)
Similarity:420/1243 - (33%) Gaps:484/1243 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 LIRETRQLLWATVATQ----TPRTDYEG-------------AIQLREIREIRVGKHS-------- 84
            |.|.::.:.|...|:.    |.|.|..|             .:.:..||:.|.|:::        
Mouse    22 LRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKI 86

  Fly    85 KEFRLFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMVKDTLGAPYPLQI 149
            :|...|.....|.|.....|:...:.......:.:|:.:.....|...|..:..:.|.  .....
Mouse    87 REVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNFMAVQDDTVKVWSEELFKLAMNILA--QNASR 149

  Fly   150 DRWLRREYYQIENVNTHSAKATEQSPAQVTIKD-FKLFLAG--------VSCKMTTGKFMEHFTE 205
            :.:||:.|.::        |.......::.:|: .|:|.|.        .||.:...:     :|
Mouse   150 NTFLRKAYTKL--------KLQVNQDGRIPVKNILKMFSADKKRVETALESCGLNFNR-----SE 201

  Fly   206 DVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSA 270
            .: |..:...:.|.|...||.|......:|...|....||...:|      |..|:..:|||...
Mouse   202 SI-RPDEFPLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQ------LMDFINQKQRDPRL 259

  Fly   271 SEI-----SSAAIASFIRDF---VQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMN 327
            :|:     .|:.....|..:   .|.:|||    .::...|..:|..::|.:...:...:.|||.
Mouse   260 NEVLYPPLRSSQARLLIEKYETNKQFLERD----QMSMEGFSRYLGGEENGILPLEALDLSMDMT 320

  Fly   328 LPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNG--PDNLPYIFHGHTITS 390
            .|||:|:|.||||||||..|.:..||.|.|.:||..||||:|||.|.|  |:..|:|.||.|:|:
Mouse   321 QPLSAYFINSSHNTYLTAGQLAGPSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTT 385

  Fly   391 KIKFMDVIKTIKDHAFTSSEYPVILSIEQNC-SLEQQRNMAQALIEVFGDMLLTQPCDRNEQH-- 452
            ::...||::.|.:.||.:|.||||||.|.:. |.:||..||:....:|||.||..|.|:....  
Mouse   386 EVPLRDVLEAIAEAAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIDPLDKYPLSAG 450

  Fly   453 --LPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEG 515
              ||||..|..:|::|:||                 .||.|.|                      
Mouse   451 IPLPSPQDLMGRILVKNKK-----------------RHRPSTG---------------------- 476

  Fly   516 LLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSAN 580
                                                                             
Mouse   477 ----------------------------------------------------------------- 476

  Fly   581 DELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKL 645
                                                        |.|.|:    |.||      |
Mouse   477 --------------------------------------------VPDSSV----RKRP------L 487

  Fly   646 KHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQ 710
            :..|.::                           ||.|...:...||                  
Mouse   488 EQSNSAL---------------------------SESSAATEPSSPQ------------------ 507

  Fly   711 AEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYT 775
                     :||    ||..|                |..:..|...|::..:.|...||     
Mouse   508 ---------LGS----PSSDS----------------CPGLSNGEEVGLEKTSLEPQKSL----- 538

  Fly   776 RNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKP 840
                                        |:.|...:.|                           
Mouse   539 ----------------------------GEESLSREPN--------------------------- 548

  Fly   841 DELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIE 905
                                                  |.:.|...||.....||.         
Mouse   549 --------------------------------------VPMPDRDREDEEEDEEEE--------- 566

  Fly   906 IFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKK 970
                     |:.||        :.||         .::.||...:.|                  
Mouse   567 ---------ETTDP--------KKPT---------TDEGTASSEVNA------------------ 587

  Fly   971 ERTARVAKEMSDLIIYFRSVPF------REHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQ 1029
                  .:|||.|:.|...|.|      |:.:..| |||||.||||.:|..:...: |:.|::.|
Mouse   588 ------TEEMSTLVNYVEPVKFKSFEAARKRNKCF-EMSSFVETKAMEQLTKSPME-FVEYNKQQ 644

  Fly  1030 ISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMK-- 1092
            :||:||||.|:||||:.|..|||||.|::|||:||.|..||||...|..||:.||:|||.||:  
Mouse   645 LSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRP 709

  Fly  1093 SDSFNP-NNPLCDGLSEVKVSIRLIAARHLFRGGKSNNPQIVVELIGASFDTGVKYRTKVNE-NG 1155
            ..||:| ...:.||:....:.:::|:.:  |...|.....:.|::.|...||..||||:.:: |.
Mouse   710 DKSFDPFTEVIVDGIVANALRVKVISGQ--FLSDKKVGIYVEVDMFGLPVDTRRKYRTRTSQGNS 772

  Fly  1156 FNPVWNES-CEF-NVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEE 1218
            |||||:|. .:| .|..|..|.||....:|.    ..|:.....|::.||.||..|.|||:.::.
Mouse   773 FNPVWDEEPFDFPKVVLPTLASLRIAAFEEG----GKFVGHRILPVSAIRSGYHYVCLRNEANQP 833

  Fly  1219 LELSSLLI 1226
            |.|.:|||
Mouse   834 LCLPALLI 841

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 21/126 (17%)
PI-PLCc_gamma 323..>470 CDD:176534 72/153 (47%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 9/97 (9%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 11/99 (11%)
SH3_PLCgamma 828..880 CDD:212759 0/51 (0%)
PLCYc 981..1091 CDD:128454 56/115 (49%)
C2_PLC_like 1109..1215 CDD:175974 35/108 (32%)
Plcb3NP_001277278.1 PH_PLC_beta 22..149 CDD:270167 21/128 (16%)
EF-hand_like 225..315 CDD:286375 20/99 (20%)
PI-PLCc_beta 316..694 CDD:176533 169/768 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 466..588 48/510 (9%)
C2_PLC_like 729..844 CDD:175974 40/119 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 888..938
BAR 976..>1118 CDD:299863
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1001..1026
PLC-beta_C 1029..1202 CDD:285865
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1207..1234
Interaction with SHANK2. /evidence=ECO:0000250 1231..1234
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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