DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sl and Plcb2

DIOPT Version :9

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_808236.2 Gene:Plcb2 / 18796 MGIID:107465 Length:1181 Species:Mus musculus


Alignment Length:1230 Identity:259/1230 - (21%)
Similarity:383/1230 - (31%) Gaps:555/1230 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 IQLREIREIRVGKHSK---------EFRL-FADDCQRFESSKCFVILHGNHFKLKSFSV------ 118
            :.:..||:.|.||.:|         .|.: |.|                |||.||:.:|      
Mouse    59 LDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPD----------------NHFLLKTLTVVSGPDM 107

  Fly   119 --------VALSEIEADNWVRGLRYMVKD--TLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQ 173
                    |:..|....:|...:..:.|.  |:.||....:|:.|.:...|:            .
Mouse   108 VDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQL------------N 160

  Fly   174 SPAQVTIKD-FKLFLAG--------VSCKMTTGK----FMEHFTEDVRRKHDL------KFDDFS 219
            ...::.:|: |::|.|.        .:|.:..||    ..|.|.|.|.:...:      :.|:..
Mouse   161 PEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIF 225

  Fly   220 RLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSASEI----SSAAIAS 280
            ..|                      :|:.:..:....|.:|:..:|||...:.:    :......
Mouse   226 TSY----------------------HSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQ 268

  Fly   281 FIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTG 345
            .:.|..:....:||...|:....|.||...:|.:.......:..||..||:.|:|.||||||||.
Mouse   269 VLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTA 333

  Fly   346 DQFSSESSCEAYARALRMGCRCIELDCWNG--PDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTS 408
            .|||..||.|.|.:.|..||||:|||||.|  ||..|.|.||.|:|:.|.|.:.|:.|.:.||.:
Mouse   334 GQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKT 398

  Fly   409 SEYPVILSIEQNC-SLEQQRNMAQALIEVFGDMLLTQPCD----RNEQHLPSPYQLRRKIILKHK 468
            |.||||||.|.:. |..||..||:....:||:.|||.|.:    :....||||..||.||::|:|
Mouse   399 SPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNK 463

  Fly   469 KLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDPVDKSWNLYQFV 533
            | .||.            |..|.....||.|.|                                
Mouse   464 K-NQFS------------GPASPSKKPGGVAEG-------------------------------- 483

  Fly   534 LTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEGGR 598
                                           ||.|::                            
Mouse   484 -------------------------------SLPSSV---------------------------- 489

  Fly   599 KEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFD 663
                                                                             
Mouse   490 ----------------------------------------------------------------- 489

  Fly   664 SLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPS 728
                                     ||     .||..|...:.|:.:.|:               
Mouse   490 -------------------------PV-----EEDTGWTAEDRTEVEEEE--------------- 509

  Fly   729 VQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQEL 793
                                                                             
Mouse   510 ----------------------------------------------------------------- 509

  Fly   794 LRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRDN 858
                :.|..:.:.||             ||:|.                                
Mouse   510 ----VVEEEEEEESG-------------NLDEE-------------------------------- 525

  Fly   859 SMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIF 923
                      .|||                  ..::|||.|    :|:                 
Mouse   526 ----------EIKK------------------MQSDEGTAG----LEV----------------- 541

  Fly   924 KLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFR 988
                                 ||||                              |||.|:.|.:
Mouse   542 ---------------------TAYE------------------------------EMSSLVNYIQ 555

  Fly   989 SVPFREHSWIFQE-----MSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPM 1048
            ...|....:..|:     :|||.|.||.:...:.:.| |:.|::.|:|||||||.|:||||:.|.
Mouse   556 PTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQ-FVDYNKRQMSRVYPKGTRMDSSNYMPQ 619

  Fly  1049 PFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMK--SDSFNP-NNPLCDGLSEVK 1110
            .|||.|.||:|||:||.|..||.|.|.|..|||.||:||..||:  ...||| :....|.:....
Mouse   620 MFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATT 684

  Fly  1111 VSIRLIAARHLFRGGKSNNPQIVVELIGASFDTGVKYRTKVN--ENGFNPVWNESCEF---NVRN 1170
            :||.:|:.:  |...:|....:.|||.|...|...:||||::  .|..||||.|. .|   .:..
Mouse   685 LSITIISGQ--FLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEE-PFIFEKILM 746

  Fly  1171 PQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKI 1230
            |:.|.||..|.:|.    :.|:.....|:..:..||..:.||::.:..|.:.:|.:.:::
Mouse   747 PELASLRIAVMEEG----SKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEM 802

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 22/102 (22%)
PI-PLCc_gamma 323..>470 CDD:176534 75/153 (49%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 0/97 (0%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 5/99 (5%)
SH3_PLCgamma 828..880 CDD:212759 3/51 (6%)
PLCYc 981..1091 CDD:128454 52/114 (46%)
C2_PLC_like 1109..1215 CDD:175974 33/110 (30%)
Plcb2NP_808236.2 PH_PLC_beta 17..144 CDD:270167 21/100 (21%)
PLN02222 219..801 CDD:177868 223/1039 (21%)
EF-hand_like 220..311 CDD:286375 16/112 (14%)
PI-PLCc_beta2 311..650 CDD:176561 159/767 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 465..534 27/423 (6%)
C2_PLC_like 682..803 CDD:175974 35/128 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..890
PLC-beta_C 974..1149 CDD:285865
DUF904 1038..1117 CDD:299763
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1149..1181
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841983
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.750

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