DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and Plcb1

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	NP_001139302.1	Gene:	Plcb1 / 18795	MGIID:	97613	Length:	1216	Species:	Mus musculus

Alignment Length:	1242	Identity:	254/1242 - (20%)
Similarity:	405/1242 - (32%)	Gaps:	524/1242 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LIRETRQLLWATVAT-QTP---RTDYEG-------------AIQLREIREIRVGKHSK-----EF 87
            |.:.|:.:.|...:| .||   |||.:|             .:.|..:::.|.|||:|     :.
Mouse    22 LKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHAKAPKDPKL 86

  Fly    88 RLFAD--DCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMVKDTLGAPYPLQID 150
            |...|  :....|.....|:...:...:...::||..|..|..|...:..:..:.|.  ..:..|
Mouse    87 RELLDVGNIGHLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLA--QNMSRD 149

  Fly   151 RWLRREYYQIENVNTHSAKATEQSPAQVTIKD-FKLFLAG--------VSCKMTTGKF----MEH 202
            .:|.:.|.::        |.......::.:|: ::||.|.        .:|.:.:.:.    .|.
Mouse   150 AFLEKAYTKL--------KLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQED 206

  Fly   203 FTEDVRRKHDLKFDDFSRLYQKLLLPN-GFASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQR 266
            ||.||           .|::...|.|. ...::.|..|..:.||....|::      .|:..:||
Mouse   207 FTPDV-----------YRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMM------DFINLKQR 254

  Fly   267 DVSASEISSAAI-ASFIRDFVQDVERD---VQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMN 327
            |...:||....: ...::..::..|.:   .::..::...|:.:|..::|.:.:.:...:..||:
Mouse   255 DPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLSGEENGVVSPEKLDLNEDMS 319

  Fly   328 LPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNG--PDNLPYIFHGHTITS 390
            .|||.|:|.||||||||..|.:..||.|.|.:.|..||||:|||||.|  .:..|.|.||.|:|:
Mouse   320 QPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTT 384

  Fly   391 KIKFMDVIKTIKDHAFTSSEYPVILSIEQNC-SLEQQRNMAQALIEVFGDMLLTQPCDR----NE 450
            :|.|.:||:.|.:.||.:|.:|::||.|.:. |.:||..||:....:|||.||.:|.::    :.
Mouse   385 EISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESG 449

  Fly   451 QHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEG 515
            ..||||..|..||::|:||                ..|:||            :|...:|:.::.
Mouse   450 VPLPSPMDLMYKILVKNKK----------------KSHKSS------------EGSGKKKLSEQA 486

  Fly   516 LLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSAN 580
            ...:.|.                   ||....|..|..|                    .||.::
Mouse   487 SNTYSDS-------------------SSVFEPSSPGAGE--------------------ADTESD 512

  Fly   581 DELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKL 645
            |:                 :.||..||
Mouse   513 DD-----------------DDDDDCKK-------------------------------------- 522

  Fly   646 KHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQ 710
                                             ||
Mouse   523 ---------------------------------SS------------------------------ 524

  Fly   711 AEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYT 775
                                                    |.||.. |.:.|..|.:.:|:||.
Mouse   525 ----------------------------------------MDEGTA-GSEAMATEEMSNLVNYI- 547

  Fly   776 RNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKP 840
                       .||..|                                         |::.:|.
Mouse   548 -----------QPVKFE-----------------------------------------SFEISKK 560

  Fly   841 DELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIE 905
            ...||
Mouse   561 RNKSF------------------------------------------------------------ 565

  Fly   906 IFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKK 970

Mouse   566 ----------------------------------------------------------------- 565

  Fly   971 ERTARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYP 1035
                                          |||||.|||..:|..:...: |:.|::.|:||:||
Mouse   566 ------------------------------EMSSFVETKGLEQLTKSPVE-FVEYNKMQLSRIYP 599

  Fly  1036 KGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMK--SDSFNP 1098
            ||.|:||||:.|..|||.|.||:|||:||.|.|||:|...:..||:.||.|||.||:  ...|:|
Mouse   600 KGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDP 664

  Fly  1099 -NNPLCDGLSEVKVSIRLIAARHLFRGGKSNNPQIVVELIGASFDTGVK-YRTKVNE-NGFNPVW 1160
             ...:.||:....:|:::|:.:  |...|.....:.|::.|...||..| ::||.:: |..||||
Mouse   665 FTEGIVDGIVANTLSVKIISGQ--FLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVW 727

  Fly  1161 NES-CEF-NVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSS 1223
            .|. ..| .|..|..|.||....:|.    ..||.....|:..||.||..:.|||:.::.|.|.:
Mouse   728 EEEPIVFKKVVLPSLACLRIAAYEEG----GKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788

  Fly  1224 LLINIKI 1230
            :.:.|::
Mouse   789 VFVYIEV 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	26/125 (21%)
		PI-PLCc_gamma	323..>470	CDD:176534	69/153 (45%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	6/97 (6%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	12/99 (12%)
		SH3_PLCgamma	828..880	CDD:212759	4/51 (8%)
		PLCYc	981..1091	CDD:128454	47/109 (43%)
		C2_PLC_like	1109..1215	CDD:175974	34/109 (31%)
Plcb1	NP_001139302.1	PH_PLC_beta	22..148	CDD:270167	26/127 (20%)
		PLN02952	216..784	CDD:178538	210/1014 (21%)
		EF-hand_like	224..314	CDD:286375	15/95 (16%)
		PI-PLCc_beta	316..643	CDD:176533	146/761 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	469..534		24/274 (9%)
		C2_PLC_like	677..796	CDD:175974	37/125 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..891
		DUF1154	903..939	CDD:284131
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	967..989
		PLC-beta_C	1003..1172	CDD:285865
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1072..1095
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1173..1216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750