DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and pll-1

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	NP_741068.1	Gene:	pll-1 / 187273	WormBaseID:	WBGene00004045	Length:	1075	Species:	Caenorhabditis elegans

Alignment Length:	1245	Identity:	242/1245 - (19%)
Similarity:	389/1245 - (31%)	Gaps:	544/1245 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LERGTIVTKLYGKQRRPDRRHLMLIRETRQLLWATVATQTPRTDYEGAIQLREIREIRVGKHSKE 86
            ::.|:...||.|..|: .||...|..:...:.|    |.|.:..::..|.:.||||||:||:::.
Worm    82 MQTGSDFVKLRGTNRQ-FRRFFSLDADLSYIRW----TPTNKKPHKARIAIDEIREIRLGKNTEL 141

  Fly    87 FR----LFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGL------RYMVKDTL 141
            .|    :|.|    .:....|.|::|:::  ::..::|.|..:|:.||.||      :|..|.:
Worm   142 LRSSDEVFTD----LQEECLFSIIYGDNY--ETLDLIASSGDDANIWVTGLMALTSNKYECKPS- 199

  Fly   142 GAPYPLQIDRWLRREYYQIE-NVNTHSAKATEQSPAQVTIKDFKLFL---AGVSCKMTTGKFME- 201
            .:.:....:||:...:.:.: ..|.|..:.|.          ||..|   :.:|....|.|..|
Worm   200 SSQFATLRERWIESVFDEFDTKKNGHLDEQTA----------FKAILHINSRISHHRLTNKLKEV 254

  Fly   202 --HFTEDVRRKHDLKFDDFSRLYQKL-LLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQFLET 263
              ...|..|.|  ::...|..||::: ..|..:..::.   .||..|...|      :|:.||||
Worm   255 TIGAEESERGK--IEKSHFVDLYKEIGTRPEVYFLMVR---YANKDYLSCQ------DLRLFLET 308

  Fly   264 EQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNL 328
            ||..|..:..:...:........:..|.::    :|...|..||||....:::..:..|.|||..
Worm   309 EQGMVGVTTDNCETLIEQYEPCSEARENNL----MTVDGFTSFLFSPDCGVFDPNHRVVTMDMKQ 369

  Fly   329 PLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWN----GPDNLPYIFHGHTIT 389
            |.|.|:|:||..:||..||....|| :.::.||:..||.:|.|.|:    ..|..|.:.:|.|.|
Worm   370 PFSRYFISSSRKSYLVEDQLGPSSS-DGFSSALKRNCRFLEFDIWDPNEADGDTEPMVQNGQTAT 433

  Fly   390 SKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCD----RNE 450
            |||.....::.|::.||..|.||::|.:..:||.:.|:..|..::...|..|.....|    .:|
Worm   434 SKITISSALRIIREFAFERSRYPLLLKVSVHCSTDWQKVAAMLIVTHLGTRLYLPKNDPTNWDDE 498

  Fly   451 QHLPSPYQLRRKIILKHKKL--PQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFK 513
            ::.|:|:..:.:|::..|||  |..|
Worm   499 KNCPTPWDFQNRILIVGKKLDNPDTD--------------------------------------- 524

  Fly   514 EGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTS 578
                                        |.|:       ||:||       ||.|..::|.|
Worm   525 ----------------------------SGEV-------SEEDD-------SLASTTRRKSK--- 544

  Fly   579 ANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRI 643
                                                                           ||
Worm   545 ---------------------------------------------------------------RI 546

  Fly   644 KLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTK 708
            :|
Worm   547 QL--------------------------------------------------------------- 548

  Fly   709 EQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINY 773
                                                   |:                .|..|:
Worm   549 ---------------------------------------CK----------------ELSDLV-- 556

  Fly   774 YTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKAN 838
                |::.|||..:.         |...|.|..:.....|.||      :.|:...:.:::|
Worm   557 ----PVFFNVKTLND---------LLSTAPGSTTMSSRKNLAS------VTESTCLRLMHTY--- 599

  Fly   839 KPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDS 903

Worm   600 ----------------------------------------------------------------- 599

  Fly   904 IEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERR 968
                                                                        |:|
Worm   600 ------------------------------------------------------------ATE-- 602

  Fly   969 KKERTARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRV 1033
                                                          |.|.|       ||...||
Worm   603 ----------------------------------------------FGQAT-------RNYCVRV 614

  Fly  1034 YPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSDSFNP 1098
            :|...|:||||.||..|||.|.||:.|||||....|.|.:.||.:||.|||:|||..||.|.|.|
Worm   615 FPNPSRVDSSNLNPQEFWNNGVQMVCLNYQTPGLMMDLQEGKFSDNGGCGYVLKPQVMKDDMFVP 679

  Fly  1099 NNPLCDGLSEVKVSIRLIAARHLFR------GGKSNNPQIVVELIGASFDTGVKYRTKVNENGFN 1157
            ::.:  ..|...:.:|:::.:.|.|      .|.|.:|.:|||:.|...|...:....|..:..|
Worm   680 SDRV--PTSPQILHLRILSGQQLPRPRGSNAKGDSADPFVVVEVFGLPGDCAEERTRTVRNDSIN 742

  Fly  1158 PVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELS 1222
            |.::||.:|.|..|:.|::||.|.|:|...: .||.|...|..|::.|||.:.|.|...:.||.:
Worm   743 PSFDESFQFQVSVPELALVRFLVLDDDYIGD-DFIGQYTIPFECLQPGYRHIYLLNNEGDPLEHA 806

  Fly  1223 SLLINIKIAN 1232
            :|.:::.|.|
Worm   807 TLFVHVAITN 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	35/134 (26%)
		PI-PLCc_gamma	323..>470	CDD:176534	49/154 (32%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	3/97 (3%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	7/99 (7%)
		SH3_PLCgamma	828..880	CDD:212759	1/51 (2%)
		PLCYc	981..1091	CDD:128454	38/109 (35%)
		C2_PLC_like	1109..1215	CDD:175974	35/111 (32%)
pll-1	NP_741068.1	PH_PLC_eta	82..191	CDD:270170	33/119 (28%)
		PLN02228	275..817	CDD:177873	190/1028 (18%)
		EF-hand_like	283..363	CDD:286375	19/92 (21%)
		PI-PLCc_eukaryota	364..660	CDD:176501	114/765 (15%)
		C2_PLC_like	687..815	CDD:175974	38/128 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R928
SonicParanoid	1	1.000	-	-		X101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950