Protein Alignment sl and pll-1

DIOPT Version :10

• Sequence 1: NP_476726.2
• Gene: sl / 32601
• FlyBaseID: FBgn0003416
• Length: 1236
• Species: Drosophila melanogaster
• Sequence 2: NP_741068.1
• Gene: pll-1 / 187273
• WormBaseID: WBGene00004045
• Length: 1075
• Species: Caenorhabditis elegans
• Alignment Length: 1245
• Identity: 242/1245 - (19%)
• Similarity: 389/1245 - (31%)
• Gaps: 544/1245 - (43%)

  Fly    22 LERGTIVTKLYGKQRRPDRRHLMLIRETRQLLWATVATQTPRTDYEGAIQLREIREIRVGKHSKE 86
            ::.|:...||.|..|: .||...|..:...:.|    |.|.:..::..|.:.||||||:||:::.
 Worm    82 MQTGSDFVKLRGTNRQ-FRRFFSLDADLSYIRW----TPTNKKPHKARIAIDEIREIRLGKNTEL 141

  Fly    87 FR----LFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGL------RYMVKDTL 141
            .|    :|.|    .:....|.|::|:::  ::..::|.|..:|:.||.||      :|..|.:
 Worm   142 LRSSDEVFTD----LQEECLFSIIYGDNY--ETLDLIASSGDDANIWVTGLMALTSNKYECKPS- 199

  Fly   142 GAPYPLQIDRWLRREYYQIE-NVNTHSAKATEQSPAQVTIKDFKLFL---AGVSCKMTTGKFME- 201
            .:.:....:||:...:.:.: ..|.|..:.|.          ||..|   :.:|....|.|..|
 Worm   200 SSQFATLRERWIESVFDEFDTKKNGHLDEQTA----------FKAILHINSRISHHRLTNKLKEV 254

  Fly   202 --HFTEDVRRKHDLKFDDFSRLYQKL-LLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQFLET 263
              ...|..|.|  ::...|..||::: ..|..:..::.   .||..|...|      :|:.||||
 Worm   255 TIGAEESERGK--IEKSHFVDLYKEIGTRPEVYFLMVR---YANKDYLSCQ------DLRLFLET 308

  Fly   264 EQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNL 328
            ||..|..:..:...:........:..|.::    :|...|..||||....:::..:..|.|||..
 Worm   309 EQGMVGVTTDNCETLIEQYEPCSEARENNL----MTVDGFTSFLFSPDCGVFDPNHRVVTMDMKQ 369

  Fly   329 PLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWN----GPDNLPYIFHGHTIT 389
            |.|.|:|:||..:||..||....|| :.::.||:..||.:|.|.|:    ..|..|.:.:|.|.|
 Worm   370 PFSRYFISSSRKSYLVEDQLGPSSS-DGFSSALKRNCRFLEFDIWDPNEADGDTEPMVQNGQTAT 433

  Fly   390 SKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCD----RNE 450
            |||.....::.|::.||..|.||::|.:..:||.:.|:..|..::...|..|.....|    .:|
 Worm   434 SKITISSALRIIREFAFERSRYPLLLKVSVHCSTDWQKVAAMLIVTHLGTRLYLPKNDPTNWDDE 498

  Fly   451 QHLPSPYQLRRKIILKHKKL--PQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFK 513
            ::.|:|:..:.:|::..|||  |..|
 Worm   499 KNCPTPWDFQNRILIVGKKLDNPDTD--------------------------------------- 524

  Fly   514 EGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTS 578
                                        |.|:       ||:||       ||.|..::|.|
 Worm   525 ----------------------------SGEV-------SEEDD-------SLASTTRRKSK--- 544

  Fly   579 ANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRI 643
                                                                           ||
 Worm   545 ---------------------------------------------------------------RI 546

  Fly   644 KLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTK 708
            :|
 Worm   547 QL--------------------------------------------------------------- 548

  Fly   709 EQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINY 773
                                                   |:                .|..|:
 Worm   549 ---------------------------------------CK----------------ELSDLV-- 556

  Fly   774 YTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKAN 838
                |::.|||..:.         |...|.|..:.....|.||      :.|:...:.:::|
 Worm   557 ----PVFFNVKTLND---------LLSTAPGSTTMSSRKNLAS------VTESTCLRLMHTY--- 599

  Fly   839 KPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDS 903
                                                                             
 Worm   600 ----------------------------------------------------------------- 599

  Fly   904 IEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERR 968
                                                                        |:|
 Worm   600 ------------------------------------------------------------ATE-- 602

  Fly   969 KKERTARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRV 1033
                                                          |.|.|       ||...||
 Worm   603 ----------------------------------------------FGQAT-------RNYCVRV 614

  Fly  1034 YPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSDSFNP 1098
            :|...|:||||.||..|||.|.||:.|||||....|.|.:.||.:||.|||:|||..||.|.|.|
 Worm   615 FPNPSRVDSSNLNPQEFWNNGVQMVCLNYQTPGLMMDLQEGKFSDNGGCGYVLKPQVMKDDMFVP 679

  Fly  1099 NNPLCDGLSEVKVSIRLIAARHLFR------GGKSNNPQIVVELIGASFDTGVKYRTKVNENGFN 1157
            ::.:  ..|...:.:|:::.:.|.|      .|.|.:|.:|||:.|...|...:....|..:..|
 Worm   680 SDRV--PTSPQILHLRILSGQQLPRPRGSNAKGDSADPFVVVEVFGLPGDCAEERTRTVRNDSIN 742

  Fly  1158 PVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELS 1222
            |.::||.:|.|..|:.|::||.|.|:|...: .||.|...|..|::.|||.:.|.|...:.||.:
 Worm   743 PSFDESFQFQVSVPELALVRFLVLDDDYIGD-DFIGQYTIPFECLQPGYRHIYLLNNEGDPLEHA 806

  Fly  1223 SLLINIKIAN 1232
            :|.:::.|.|
 Worm   807 TLFVHVAITN 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	35/134 (26%)
		EFh_PI-PLCgamma	152..311	CDD:320031	37/166 (22%)
		EF-hand motif	152..191	CDD:320031	7/42 (17%)
		EF-hand motif	198..226	CDD:320031	8/31 (26%)
		EF-hand motif	230..265	CDD:320031	9/34 (26%)
		EF-hand motif	277..311	CDD:320031	7/33 (21%)
		PI-PLCc_gamma	323..>470	CDD:176534	49/154 (32%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	3/97 (3%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	7/99 (7%)
		SH3_PLCgamma	828..880	CDD:212759	1/51 (2%)
		PLCYc	981..1091	CDD:128454	38/109 (35%)
		C2_PLC_like	1109..1215	CDD:175974	35/111 (32%)
pll-1	NP_741068.1	PH_PLC_eta	82..191	CDD:270170	33/119 (28%)
		EFh_PRIP	210..352	CDD:320036	37/166 (22%)
		EF-hand motif	210..239	CDD:320036	7/38 (18%)
		EF-hand motif	246..279	CDD:320036	9/34 (26%)
		EF-hand motif	283..310	CDD:320036	9/35 (26%)
		EF-hand motif	319..352	CDD:320036	7/36 (19%)
		PI-PLCc_eukaryota	364..660	CDD:176501	114/765 (15%)
		C2_PLC_like	687..815	CDD:175974	38/128 (30%)