DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and plc-2

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	NP_506752.1	Gene:	plc-2 / 180029	WormBaseID:	WBGene00004037	Length:	896	Species:	Caenorhabditis elegans

Alignment Length:	1261	Identity:	227/1261 - (18%)
Similarity:	364/1261 - (28%)	Gaps:	595/1261 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 TPRTDYE-GAIQLREIREIRVGKHSKEFRLFADDCQRFESS---------------KCFVILHGN 109
            |....|| ..|.|..|.::|.||.: :|.|...: :.:|.:               ..||.:..|
Worm    52 TKELAYEKNYIYLERIYDVRAGKPT-DFELVPSE-RSYEPNFLTIVSGTSITNLKFTHFVCMEKN 114

  Fly   110 HFKLKSFSVVALSEIE-ADNWVRGLRYMVKDTLGAP--YPLQIDRWLRREYYQIENVNTHSAKAT 171
            ..:|..|:....:.:: ......||.|..:..| ||  |.....|.:..:..::  .:.|...:|
Worm   115 EKRLHEFAATLFTVVQRVKREEHGLLYHFRKKL-APKMYAAFTRRCIEEDIMKV--FDKHRKNST 176

  Fly   172 EQSPAQVTIKDFKLFLAGVSCKMTTGKFMEHFTEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLS 236
            :....:|                  ||.:     .|.|| .::.||     |||:......:...
Worm   177 KIEWTEV------------------GKLL-----PVNRK-SVEIDD-----QKLIKIIMILTKFE 212

  Fly   237 GSGV-ANF-PYSEDQQVVRPAELKQFLETEQ-----RDVSASEISSAAIASFIRDFVQDVERDVQ 294
            ||.: |.| ..|||:.|....|...:|...|     .|...:::|...|.|.:.::....:..:.
Worm   213 GSRLEAIFRKISEDEPVATKLEFGDWLRKNQHDHRLNDARFNQVSDRKINSILENWQYSSDSAIS 277

  Fly   295 EPYLTFPE-FVDFLFSKQNDLWNSKYDQVFMD---MNLPLSSYWIASSHNTYLTGDQF-----SS 350
                  |: |..::.|.:..:..|. .::.||   |..|::.|:|.||||||.:|:|.     ..
Worm   278 ------PQMFTHWMVSDECGVAISA-QRMKMDVTSMREPINKYFINSSHNTYCSGNQLVYAIGHC 335

  Fly   351 ESSCEAYARALRMGCRCIELDCWNG--PDNLPYIFHGHTIT---SKIKFMDVIKTIKDHAFTSSE 410
            .:..|.|.:||..|.||:|||.|:.  .|..|.|.||.|..   ::|...:|.:.||:.||.:|.
Worm   336 SADVEMYRQALLSGSRCVELDMWDNKDKDGEPVITHGPTAVMGMNEIGLKEVCEAIKECAFKTSP 400

  Fly   411 YPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPC---------DRNEQHLPSPYQLRRKIILK 466
            ||||||||.:...:||..|.|...:|||::|||.|.         ...:...|.|..|:.||::|
Worm   401 YPVILSIENHLGRKQQEKMVQIFRQVFGELLLTGPLPDYPLYAKEGAGDVVYPPPELLKHKILIK 465

  Fly   467 HKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDPVDKSWNLYQ 531
            .||                                        |.|
Worm   466 AKK----------------------------------------KRF------------------- 471

  Fly   532 FVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEG 596
                        |..|||:.:|...|            :|....|.:.::|:
Worm   472 ------------EKQESRSRDSSSID------------LQGSSIDLTEDEEM------------- 499

  Fly   597 GRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFV 661
                                                                         ||..
Worm   500 -------------------------------------------------------------ENER 503

  Fly   662 FDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVR 726
            |:.|                                         |:||
Worm   504 FNEL-----------------------------------------TEEQ---------------- 511

  Fly   727 PSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQ 791

Worm   512 ----------------------------------------------------------------- 511

  Fly   792 ELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQR 856
                    :|||                .|.|.|..||..|                :.||
Worm   512 --------KAAQ----------------LSELPEETTCSEL----------------SAIT---- 532

  Fly   857 DNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGI 921
                                ||::..:::.                                 |:
Worm   533 --------------------NYMQAYETSR---------------------------------GV 544

  Fly   922 IFKLQIQTPTMQ-NPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLII 985
            ...:.::..|.. .|.::..| :.|.|..::|
Worm   545 STVVNLENATKDIVPCIVSAD-ENTVYNCLRA--------------------------------- 575

  Fly   986 YFRSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPF 1050
                             :|..:.:              :.::::|:|:|||..|:.|:|:|||..
Worm   576 -----------------NSIDKVQ--------------NLNKSKITRIYPKASRIYSTNYNPMIH 609

  Fly  1051 WNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSDSFNPNNPLCDGLS-----EVK 1110
            |..||||::||.||....||||.|.|..||.|||:.||.::::    .|..|...||     ...
Worm   610 WLTGSQMVSLNIQTNCSNMQLNYAMFERNGGCGYVRKPDWLRA----RNVQLRPFLSIPFTIAYT 670

  Fly  1111 VSIRLIAARHLFRGGKSNNPQIVVELIGASFDTGVKYRTKVN--------------ENGFNP--- 1158
            |.:.:|||..|                 :|.|:| |:|.:.:              ::..:|
Worm   671 VEVEIIAAYFL-----------------SSMDSG-KFRRRSSVSIRLFDVPDQISKDDAASPSVS 717

  Fly  1159 ---VWNESCEFNVRNPQFAILRFEVQ----DEDMFAETHFI------------AQACYPLTCIRQ 1204
               .:..||....|.....:..:|..    |:.|..:..||            ||....:..:..
Worm   718 TAAKFESSCRRRTREEASFVTNYERHVYSFDKIMLNDMSFIQFNVHNESGSVFAQRILHIDTMNN 782

  Fly  1205 GYRSVILRNKFSEELELSSLLINIKI 1230
            |||.|.||...::....:.||:...:
Worm   783 GYRFVTLRTPSNQCAGPACLLVRFDL 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	24/104 (23%)
		PI-PLCc_gamma	323..>470	CDD:176534	64/168 (38%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	4/97 (4%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	3/99 (3%)
		SH3_PLCgamma	828..880	CDD:212759	7/51 (14%)
		PLCYc	981..1091	CDD:128454	34/109 (31%)
		C2_PLC_like	1109..1215	CDD:175974	27/141 (19%)
plc-2	NP_506752.1	PH-like	16..134	CDD:302622	17/83 (20%)
		PI-PLCc_eukaryota	306..638	CDD:176501	128/772 (17%)
		C2_PLC_like	670..807	CDD:175974	29/154 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820