DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and plc-3

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	NP_496205.2	Gene:	plc-3 / 174586	WormBaseID:	WBGene00004038	Length:	1350	Species:	Caenorhabditis elegans

Alignment Length:	1298	Identity:	440/1298 - (33%)
Similarity:	698/1298 - (53%)	Gaps:	161/1298 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FSAMSAPLL---GEME--QTIGMLERGTIVTKL-YGKQRRPDRRHLMLIRETRQLLWATVATQTP 62
            ||..|...|   .||:  :....:|:|..|.|: ..|:..|..:.|.|.|.:||:....:.....
Worm    34 FSTASRAQLNRHNEMDFGKMFAAMEKGHKVCKIAVLKKWDPAYKQLTLDRYSRQIFLTKLELSAV 98

  Fly    63 RTDYEGAIQLREIRE----------IRVGKHSKEFRLFADDCQRFESSKCFVILHGNHFKLKSFS 117
            | :....:.:|:|||          |:|....|:.|    :...|:|....:|.:|..|.|..:.
Worm    99 R-NKPTILDIRQIREVQTLNYKLNTIKVDDKWKKDR----EIVNFDSKAILIISYGMGFALSYWI 158

  Fly   118 VVALSEIEADNWVRGLRYMVKDTL---GAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQ-- 177
            ::..||.....|.:||..::.||.   .:|:||:|:|:|.:.:..:            .|||.
Worm   159 LLFESEDACKLWSQGLHNLMMDTRDRDSSPHPLRIERFLHKHFLSL------------MSPANDA 211

  Fly   178 VTIKDFKLFL-AGVSCKMTTGKFMEHFTEDVRRKHDLKFDDFSRLYQKLL-LPNGFASVLSGSGV 240
            |..|..|.|: ..:..|:.:.: ::..|||     .:..|.||...::|: :|..|:     |..
Worm   212 VARKHMKPFVQTSLQFKVQSDQ-LQQVTED-----QMNSDQFSFASRQLIHVPELFS-----SRF 265

  Fly   241 ANFPYSEDQQ--VVRPAELKQFLETEQRDVSASEISSAAIASFIRDFVQDVER---DVQEPYLTF 300
            |:.....:::  ||......:||:.:|.|..||..:.|  ..|:..:.|:.:.   |..||.:|.
Worm   266 ADLAEKHERKGLVVTFQNFLRFLDGKQFDELASNRTRA--LEFLNRYFQEDQAYFGDRNEPSMTV 328

  Fly   301 PEFVDFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGC 365
            .||.|||||::|.||:...::|..||:.|||.|||||||||||||||..||||.:.||:||.|||
Worm   329 FEFCDFLFSRENSLWDPTNEKVTHDMSRPLSHYWIASSHNTYLTGDQLRSESSLDCYAQALLMGC 393

  Fly   366 RCIELDCWNG---PDNLPY----IFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSL 423
            ||||||||:|   |.:..:    |:||:|:||||...||:..|:.:||.:||||||||||.|||:
Worm   394 RCIELDCWDGQKKPGSAEFIDIVIYHGYTMTSKILLRDVLHVIRHYAFVTSEYPVILSIEDNCSV 458

  Fly   424 EQQRNMAQALIEVFGDMLLTQPCDRNEQHLPSPYQLRRKIILKHKKLP-QFDDIANGISSTGSLG 487
            ..||.:||.|.::.||.|||||.:|.|:.||||..|::|||:|||||| :.:|:| .:..|...
Worm   459 PAQRLLAQELKDILGDYLLTQPANREEKQLPSPAALKKKIIVKHKKLPIESEDLA-AVVKTDEF- 521

  Fly   488 HRSSLGGAGGGAHGENDGENV-RKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNG 551
                           .|.|.: |:..|:|:|..|:.....|..:.|:|....|.|..:..:..|.
Worm   522 ---------------QDTEIISRECVKKGILMVKNNNSHEWTSHVFILFPDRLCYLIQTADPENP 571

  Fly   552 NSEDDDFGLSSSCSLNSNMQQKQKDTSAN-----DELHFGENWFHGKLEGGRKEADDLLKKYKHF 611
            |  ||...:|..       ::::::|.:.     :|:|..|.||||:.|  |.||...:.::|..
Worm   572 N--DDTVSVSGD-------EEREEETPSGFGVKPEEMHVTEEWFHGRCE--RDEAKKRILEHKEK 625

  Fly   612 GDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNM 676
            |:|.|::|:|..|:||:|||.....:.:|.||:.|..:...|||.::|.|.|:||.|:.||.::.
Worm   626 GNGLFMIRDSNLFIGDFSLSILHDGKVHHVRIRSKIIDKEKKYYFMDNKVCDTLYELVSYYTRHY 690

  Fly   677 LRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRL-EIGSFLVRPSVQSINAFVISFT 740
            |.::.|.::|..|.|||:.|.:|.||.....||:||:.|..: |.|:||:|.|....:.:|:|..
Worm   691 LTTAHFKMVLTIPCPQPQPHLNQPWFSATADKEKAEELLSLVPEDGAFLIRTSSTDSSVYVLSLK 755

  Fly   741 INRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGD 805
            ::.:..|.|:.::||::.::...||:|..::.:|......|.:.|..||:::.:....||.|:..
Worm   756 VDGEFWHYRLKRDGRIFVVNQKVFENLNQIVEFYANREFVRGISLRFPVNEKDISHLTAELAEAR 820

  Fly   806 HSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGM- 869
            ..|.:.|.       .:|::.|..:||..|:....||||||.:.|||.::::..: |.|.||.:
Worm   821 TPGCYMDL-------KDLDKEVQARALRPYRGTADDELSFPANVIITVLRKEEGL-WRGRYGSLT 877

  Fly   870 -------IKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQI 927
                   :::.||.   ||..|.|.:||::...||           .:..:.:::.|.:|...|.
Worm   878 GWFPSAHVQEILPE---KVSTSETSNYNTIELAGT-----------LIERIHDADRPNVIRISQS 928

  Fly   928 QTPTMQNP-FVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVP 991
            ....|... :::...:.|.|..|...:.|.....:...|..|.||:..|:|.|:|:|::|.::||
Worm   929 NQHWMNKQYYLLAASSSEEADGWQNNLFELTRSVNTKMSILRTKEKEKRIAAELSNLVVYCQAVP 993

  Fly   992 F---REHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNV 1053
            |   ..::..|.||.||.|.|.:|..    .:..|.::..::|||||.|.|:.|:|::|:|.||.
Worm   994 FDPAHIYNDAFYEMCSFVEGKLDKLV----EKGLLPFNSRKLSRVYPNGSRITSNNYSPVPMWNA 1054

  Fly  1054 GSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSDSFNPNN--------PLCDGLSEVK 1110
            |..|:|||||||||.|||||.||..||:|||:|||.:|.:|.|:|.|        |       ::
Worm  1055 GCHMVALNYQTGDKPMQLNQGKFLANGRCGYLLKPDYMLTDDFDPTNTEKFATAYP-------IR 1112

  Fly  1111 VSIRLIAARHLFRGGKSN---NPQIVVELIGASFDTGVKYRTK-VNENGFNPVWNESCEFNVRNP 1171
            :::::|..|||.|..|:.   :|.:.:|:||...||.| ::|| :..||.||:||::..|.::.|
Worm  1113 LNVQVIGGRHLSRKDKNKGICSPFVEIEIIGMPCDTKV-FQTKTIASNGLNPIWNQTFTFEIQCP 1176

  Fly  1172 QFAILRFEVQDEDMFA--ETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKIAN 1232
            :.|::||.|:|.|...  ...||.||.:|:..||.|:|||.|:|::||||||||||:::::.:
Worm  1177 EVALIRFHVEDGDFVGPKTDPFIGQAVFPVDSIRCGFRSVPLKNQYSEELELSSLLVDVQMCS 1239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	34/138 (25%)
		PI-PLCc_gamma	323..>470	CDD:176534	92/153 (60%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	38/97 (39%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	29/100 (29%)
		SH3_PLCgamma	828..880	CDD:212759	18/59 (31%)
		PLCYc	981..1091	CDD:128454	54/112 (48%)
		C2_PLC_like	1109..1215	CDD:175974	42/111 (38%)
plc-3	NP_496205.2	PH-like	74..191	CDD:302622	29/121 (24%)
		EF-hand_like	278..350	CDD:286375	25/73 (34%)
		PI-PLCc_gamma	351..>494	CDD:176534	85/142 (60%)
		SH2_N-SH2_PLC_gamma_like	600..696	CDD:199829	38/97 (39%)
		SH2_C-SH2_PLC_gamma_like	710..813	CDD:198186	29/102 (28%)
		SH3	833..886	CDD:214620	17/53 (32%)
		PLCYc	983..1092	CDD:128454	54/112 (48%)
		C2_PLC_like	1110..1222	CDD:175974	43/119 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167216
Domainoid	1	1.000	186	1.000	Domainoid score	I2000
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1997
Inparanoid	1	1.050	657	1.000	Inparanoid score	I409
Isobase	1	0.950	-	0	Normalized mean entropy	S3205
OMA	1	1.010	-	-		QHG45872
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0003159
OrthoInspector	1	1.000	-	-		oto20730
orthoMCL	1	0.900	-	-		OOG6_104615
Panther	1	1.100	-	-	LDO	PTHR10336
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R928
SonicParanoid	1	1.000	-	-		X101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750