DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and PLCD3

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	XP_024306322.1	Gene:	PLCD3 / 113026	HGNCID:	9061	Length:	834	Species:	Homo sapiens

Alignment Length:	1242	Identity:	276/1242 - (22%)
Similarity:	424/1242 - (34%)	Gaps:	489/1242 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LGEMEQTIGMLERGTIVTKLYGKQRRPDRRHLMLIRETRQLLWATVATQTPRTDYEGAIQLREIR 76
            |.|.|....|| ||:.:.|:  :.|...:..|..::|....:|  ...:.||...:....::.|.
Human    56 LTEDEDVRAML-RGSRLRKI--RSRTWHKERLYRLQEDGLSVW--FQRRIPRAPSQHIFFVQHIE 115

  Fly    77 EIRVGKHSKEFRLFADDCQRFESSKCFVILHGNHFK--LKSFSVVALSEIEADNWVRGLRYMVKD 139
            .:|.|..|:..|.|..   .|..::|..|.    ||  .|:..:.|.:..||..|||||..:...
Human   116 AVREGHQSEGLRRFGG---AFAPARCLTIA----FKGRRKNLDLAAPTAEEAQRWVRGLTKLRAR 173

  Fly   140 TLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMT------TGK 198
            ........::|.|          ::::..:|.....::::.|:.|..|..|:..|.      ..|
Human   174 LDAMSQRERLDHW----------IHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFK 228

  Fly   199 FMEHFTEDVRRKHDLKFDDF-SRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQFLE 262
            ..:|...|  |....:.::| .||.::..|...|           ..||.:.:|:...||.:|||
Human   229 ECDHSNND--RLEGAEIEEFLRRLLKRPELEEIF-----------HQYSGEDRVLSAPELLEFLE 280

  Fly   263 TEQRDVSASEISSAAIASFIRDFVQDVERD---VQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFM 324
            .:..:        .|..:..:..:|..|.:   .|...:|...|:.:|.|.:....::.:..||.
Human   281 DQGEE--------GATLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQ 337

  Fly   325 DMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFHGHTIT 389
            |||.||:.|:|:||||||||..|....||.|||.||...||||:|||||.||...|.|:||||:|
Human   338 DMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLT 402

  Fly   390 SKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDR-NEQHL 453
            |||.|.||::.::|||||.|.||||||:|.:|.||||..||:.|..:.||||:||..|. |.:.|
Human   403 SKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEEL 467

  Fly   454 PSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGLLY 518
            |||.||:.::::|.||||                           |....||.
Human   468 PSPEQLKGRVLVKGKKLP---------------------------AARSEDGR------------ 493

  Fly   519 FKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSANDEL 583
                          .|:.:|             ..|:||             ::::::..|..:.
Human   494 --------------ALSDRE-------------EEEEDD-------------EEEEEEVEAAAQR 518

  Fly   584 HFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLKHE 648
            ...:.
Human   519 RLAKQ------------------------------------------------------------ 523

  Fly   649 NGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQ 713
                        :...|.:|.||.....||:                      .||.....|..|
Human   524 ------------ISPELSALAVYCHATRLRT----------------------LHPAPNAPQPCQ 554

  Fly   714 GLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNP 778
                                   :|....||.|
Human   555 -----------------------VSSLSERKAK-------------------------------- 564

  Fly   779 LYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANKPDEL 843
                 ||.....|:.:|           |||....|.:
Human   565 -----KLIREAGQKRVR-----------SGGRVTWGRA--------------------------- 586

  Fly   844 SFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEIFG 908
                             |.:          .|..|
Human   587 -----------------WAL----------FPGGY------------------------------ 594

  Fly   909 AVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERT 973
                     .||:                           |::              :.|...|
Human   595 ---------RPGL---------------------------WVR--------------DPRSLSR- 608

  Fly   974 ARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQ 1038
                                          |.|.:.....|.:.|.:        |::||||.|.
Human   609 ------------------------------SHPNSAPGNSFVRHNAR--------QLTRVYPLGL 635

  Fly  1039 RLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMK--SDSFNPNNP 1101
            |::|:|::|...||.|.|::|||:||....|.||..:|..||||||:|||:.::  ..:|:|..|
Human   636 RMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPEYP 700

  Fly  1102 LCDGLSEVKVSIRLIAARHLFRGGKSN--------NPQIVVELIGASFDTGVKYRTKVNENGFNP 1158
               |.....:||:::.|:.|   .|.|        :|.:.:|:.|...|...:....|..|||||
Human   701 ---GPPRTTLSIQVLTAQQL---PKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNP 759

  Fly  1159 VWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSS 1223
            .|.::.:|.:|.|:.|::||.|:|.|..:...|:.|...||:.::||||.:.|.:|....|..::
Human   760 RWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPAT 824

  Fly  1224 LLINIKI 1230
            |.|.|:|
Human   825 LFIQIRI 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	30/126 (24%)
		PI-PLCc_gamma	323..>470	CDD:176534	85/147 (58%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	6/97 (6%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	11/99 (11%)
		SH3_PLCgamma	828..880	CDD:212759	3/51 (6%)
		PLCYc	981..1091	CDD:128454	36/109 (33%)
		C2_PLC_like	1109..1215	CDD:175974	35/113 (31%)
PLCD3	XP_024306322.1	PH_PLC_delta	65..181	CDD:270169	31/127 (24%)
		EFh_PI-PLCdelta3	186..324	CDD:320048	32/168 (19%)
		EF-hand motif	186..215	CDD:320048	5/38 (13%)
		EF-hand motif	222..251	CDD:320048	6/30 (20%)
		EF-hand motif	255..287	CDD:320048	10/50 (20%)
		EF-hand motif	291..324	CDD:320048	7/32 (22%)
		PI-PLCc_delta3	336..676	CDD:176567	154/756 (20%)
		C2_PLC_like	705..832	CDD:175974	41/130 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151875
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R928
SonicParanoid	1	1.000	-	-		X101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.780