DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and LOC100496658

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	XP_017950677.1	Gene:	LOC100496658 / 100496658	-ID:	-	Length:	1301	Species:	Xenopus tropicalis

Alignment Length:	1297	Identity:	553/1297 - (42%)
Similarity:	784/1297 - (60%)	Gaps:	145/1297 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FSAMSAPLLGEMEQ----------TIGMLERGTIVTKLYGKQ-RRPDRRHLMLIRETRQLLWATV 57
            |....|.|.|.||:          |:..||.||::|..|.|: :||:||...|..:|||::|...
Frog     2 FGCRMANLNGLMEEGRGEGTDLGRTLRSLETGTVLTLFYQKKSQRPERRTFQLRMDTRQVVWFRT 66

  Fly    58 ATQTPRTDYEGAIQLREIREIRVGKHSKEFRLFADDCQRFESSKCFVILHGNHFKLKSFSVVALS 122
            ..:.     ||.|.:|||:|||.||:|::|..:.:|.::.:::.||:||:|..|:||:.|..|.|
Frog    67 TEKV-----EGDIDVREIKEIRPGKNSRDFERYPEDTRKLDATLCFIILYGTDFRLKTVSAAAFS 126

  Fly   123 EIEADNWVRGLRYMVKDTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFL 187
            |.|.:.|:.||.::|.|||.||.||||:|||.:::..::       :|.|.|   ||:||.|..|
Frog   127 EEEVNLWISGLNWVVADTLKAPGPLQIERWLGKQFNAVD-------RAREGS---VTVKDLKALL 181

  Fly   188 AGVSCKMTTGKFMEHFTEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVV 252
            ..|:.::...:|:.....::..:.:|.|..|...|..|:. :...|::....: :||.   :.|.
Frog   182 PQVNYRVPNMRFLRDKMLEIEARSELTFPHFVLFYNNLMF-DAQKSIIEQLEL-SFPL---RNVD 241

  Fly   253 RPA-------ELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSK 310
            ||:       :.::||:.:|::..|.:|:.  :..::.::::|.:.||.||.|...||:.:||||
Frog   242 RPSLCQISLYDFQRFLQFDQKEAWAGDINK--VRGYLCNYLKDSDGDVCEPILQLDEFLTYLFSK 304

  Fly   311 QNDLWNSKYDQVF-MDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWN 374
            :|.:.:|:::||. .:|..|||.|||:|||||||||||||||||.|||||.|||||||||||||:
Frog   305 ENMIMDSRFEQVVPEEMTYPLSQYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWD 369

  Fly   375 GPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGD 439
            |||:||.|:||||:||||||:||:.||||:||.:||||||||||.:||:.||||||....:||||
Frog   370 GPDDLPIIYHGHTLTSKIKFLDVLHTIKDNAFVTSEYPVILSIEDHCSVVQQRNMAHYFRKVFGD 434

  Fly   440 MLLTQPCDRNEQHLPSPYQLRRKIILKHKKLPQ---FDDIANGISSTGSLGHRSSLGGAGGGAHG 501
            ||||:|.|.|...||||.||::||::|||||.:   ::::     ||.|              :.
Frog   435 MLLTKPVDINADELPSPAQLKKKILIKHKKLVEGNLYEEV-----STAS--------------YS 480

  Fly   502 ENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSL 566
            |||   :....|.|:||.:||:|.:|:.:.||||..::.||.|.:..:: |.||:
Frog   481 END---ISNSIKNGILYLEDPIDHTWSPHYFVLTSNKIYYSEETSRYQS-NDEDE---------- 531

  Fly   567 NSNMQQKQKDTSANDELHFGENWFHGKLEG---GRKEADDLLKKY-KHFG--DGTFLVRESATFV 625
                :.:.|:...|:||||.|.||||||.|   ||:.|:.||.:| ...|  |||||||||.|||
Frog   532 ----EMEPKEEFNNNELHFSEKWFHGKLGGGRDGRQIAEKLLHEYCTETGGKDGTFLVRESETFV 592

  Fly   626 GDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPV 690
            |||:|||||.:|..||||..:.|.||.|:||.:|.||||||.||.:||:..||.:||.:.|.:||
Frog   593 GDYTLSFWRSSRVQHCRIHSRQEAGSTKFYLTDNLVFDSLYGLISHYREVPLRCNEFEMRLTDPV 657

  Fly   691 PQPKKHEDQEWFHPNTTKEQAEQGLYRL-EIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEG 754
            |||..||.:||:|.|.|:.|||..|.|: ..|:||:|...:: ::|.|||....|||||||.|||
Frog   658 PQPNAHESKEWYHANLTRLQAEHMLMRVPRDGAFLLRKRSET-SSFAISFRAEGKIKHCRIQQEG 721

  Fly   755 RLYGI-DTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNY 818
            ||:.: .:..|||||.||:||.::||||.::|.:|:::|.|.:  ...|:.|:....:......|
Frog   722 RLFMLGSSAEFESLVDLISYYEKHPLYRKMRLRYPINEEALEK--MGTAELDYDALFEGRTPHVY 784

  Fly   819 MGSNLEENVTC--KALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKV 881
            :.:|......|  ||||.|||.:.|||:|.|.|||.||.:.:..||.|||||..:...|||||
Frog   785 VEANKMPTSRCTVKALYDYKAQREDELTFCKQAIIHNVDKQDGGWWRGDYGGKKQLWFPANYV-- 847

  Fly   882 IDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDP-GIIFKLQIQTPT----------MQNP 935
             :.||...:...:||:.....|:|           |.| |...|..|..|:          ...|
Frog   848 -EETTSAMSPDQDEGSFYFGQSVE-----------NSPLGNFLKGFIDVPSCHIVSSKDGRSSRP 900

  Fly   936 FV----------------IGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLI 984
            :|                :..|.||...:||..|:||...|.....|.:..||..::|.|:|:|:
Frog   901 YVFTIHSQQMSHPSQSLDVAADTQEELNDWIGKIREATQNADARMQEGKIMERRKKIALELSELV 965

  Fly   985 IYFRSVPFRE-----HSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSN 1044
            :|.|.|||.|     ....:::|||||||||||...:...:.||.|:|.|:||||||||||||||
Frog   966 VYCRPVPFDEEKIGTEKACYRDMSSFPETKAEKYANRSKGKKFLQYNRRQLSRVYPKGQRLDSSN 1030

  Fly  1045 FNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSDSFNP--NNPLCDGLS 1107
            ::|:|.|..|||::|||:||.||.||||||.|...||.||:|:|..|:.|.|:|  .|.| ..:.
Frog  1031 YDPLPMWICGSQLVALNFQTPDKPMQLNQALFMLGGQSGYVLQPDIMRDDLFDPFDKNSL-KIVE 1094

  Fly  1108 EVKVSIRLIAARHLFRGGKS-NNPQIVVELIGASFDTGVKYRTKVNENGFNPVW-NESCEFNVRN 1170
            .:.|.::::.||||.:.|:| ..|.|.||:.|:.||........|.:||.|||| .:...|::.|
Frog  1095 PITVQLQILGARHLPKNGRSIVCPFIEVEVCGSEFDNSKSKSDVVADNGLNPVWMMKQFVFDITN 1159

  Fly  1171 PQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKIAN 1232
            |:||.|||.|.:||||::.:|:|||.:.:..::.|||||.|||.:||||||:|||::|:|.|
Frog  1160 PEFAFLRFVVYEEDMFSDPNFLAQATFSVKGLKTGYRSVPLRNSYSEELELASLLVHIEIVN 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	52/125 (42%)
		PI-PLCc_gamma	323..>470	CDD:176534	106/147 (72%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	61/103 (59%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	49/101 (49%)
		SH3_PLCgamma	828..880	CDD:212759	29/53 (55%)
		PLCYc	981..1091	CDD:128454	64/114 (56%)
		C2_PLC_like	1109..1215	CDD:175974	46/107 (43%)
LOC100496658	XP_017950677.1	PH_PLC_gamma	30..151	CDD:270168	52/125 (42%)
		EFh_PI-PLCgamma1_like	156..305	CDD:320046	40/165 (24%)
		EF-hand motif	156..185	CDD:320046	11/38 (29%)
		EF-hand motif	193..220	CDD:320046	5/26 (19%)
		EF-hand motif	226..261	CDD:320046	8/38 (21%)
		EF-hand motif	271..305	CDD:320046	11/35 (31%)
		PI-PLCc_gamma	318..>453	CDD:176534	99/134 (74%)
		PH-like	487..>523	CDD:388408	15/35 (43%)
		SH2_N-SH2_PLC_gamma_like	545..649	CDD:199829	61/103 (59%)
		SH2_C-SH2_PLC_gamma_like	663..766	CDD:198186	49/105 (47%)
		SH3_PLCgamma	796..849	CDD:212759	29/55 (53%)
		PH-like	<860..941	CDD:388408	20/91 (22%)
		PLCYc	962..1077	CDD:128454	64/114 (56%)
		C2_PLC_like	1095..1219	CDD:175974	56/123 (46%)
		Smc	<1201..>1301	CDD:224117	14/21 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	231	1.000	Domainoid score	I2389
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	942	1.000	Inparanoid score	I341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0003159
OrthoInspector	1	1.000	-	-		otm48714
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R928
SonicParanoid	1	1.000	-	-		X101
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.090