DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sl and plch2a

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	XP_009302541.1	Gene:	plch2a / 100334231	ZFINID:	ZDB-GENE-030131-6367	Length:	1557	Species:	Danio rerio

Alignment Length:	1254	Identity:	314/1254 - (25%)
Similarity:	497/1254 - (39%)	Gaps:	436/1254 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MEQTIGMLERGTIVTKLYGKQRRPDR-----RHLMLIRETRQLLWATVATQTPRTDYEGAIQLRE 74
            :|:.:..::.||.:.||.|..:...|     .|...||      |     :..|.:.:..|.:..
Zfish    79 VEKCMSSMQTGTQMVKLRGGSKGLVRFFYLDEHKSCIR------W-----RPSRKNEKAKISIDS 132

  Fly    75 IREIRVGKHSKEFRLFADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMV-- 137
            |||:..||.|:.|:.::|.  .|:.:.||.|.:|.|  ::|..:|:.:..||..|:.||:|::
Zfish   133 IREVCEGKQSEIFQRYSDG--SFDPNCCFSIYYGEH--MESLDLVSGTGEEARTWITGLKYLMAG 193

  Fly   138 ---KDTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGK- 198
               :|:| |......|:||::.:          |:|.:.....::|.:....|..::..:...|
Zfish   194 ISDEDSL-AKRQRTRDQWLKQTF----------AEADKNGDGCLSISEVLQLLHKLNVNLPRQKV 247

  Fly   199 ---FMEHFTEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAELKQF 260
               |.|..|:|  .:..|.|::|...|:.:       |......:....||..:..:...:||:|
Zfish   248 KQMFKEADTDD--NQGTLGFEEFCSFYKMM-------STRRDLYLLMLTYSNHKDHLDTDDLKRF 303

  Fly   261 LETEQRDVSAS-EISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKYDQVFM 324
            |||||:..:.| |.....:|.|     :....:.....|....|.:::.|...|::|.::.:|..
Zfish   304 LETEQKMTNVSKEHCLEIVAKF-----EPCPENQTSGVLGIDGFTNYMRSPAGDIFNPEHYEVNQ 363

  Fly   325 DMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFHGHTIT 389
            ||..|||.|:|||||||||.|||..|:|..:.||..|:.||||:|:|||:|.|..|.:.||:|:|
Zfish   364 DMTQPLSDYFIASSHNTYLMGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGQDGEPIVHHGYTLT 428

  Fly   390 SKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDML--LTQPCDRNEQH 452
            |||.|.|||:||..:||..::||||||||.:||:.||:.|||.|.||.||.|  .:.|.|.:..
Zfish   429 SKILFKDVIETINKYAFAKNQYPVILSIENHCSVPQQKKMAQYLTEVLGDKLDVSSIPADPSGL- 492

  Fly   453 LPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKEGLL 517
            ||||..|:.||::|.||||                              .|..||.    :||.:
Zfish   493 LPSPEALKGKILIKGKKLP------------------------------SNIDENA----EEGDV 523

  Fly   518 YFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSL---NSNMQQKQKDTSA 579
            ..:|..|:                           .|||       |.|   :::|.:||.:..|
Zfish   524 SDEDSADE---------------------------MEDD-------CKLLNGDTSMNRKQAENVA 554

  Fly   580 NDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIK 644
                              :|:.|:|:|:.|        :|:              |..|
Zfish   555 ------------------KKKLDNLMKESK--------IRD--------------REDP------ 573

  Fly   645 LKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKE 709
                         ::|...:|                         |...||:      .:..|.
Zfish   574 -------------DSFTITAL-------------------------PPSGKHD------KSPLKG 594

  Fly   710 QAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYY 774
            :||.                                            ..||
Zfish   595 KAED--------------------------------------------STDT------------- 602

  Fly   775 TRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSG-GHDDNGASNYMGSNLEENVTCKALYSYKAN 838
                                         ||.:. |.:...|..:|||           :|.:..
Zfish   603 -----------------------------GDEANIGGNKRLARTFMGS-----------FSKRKK 627

  Fly   839 KPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDS 903
            |..:                           :||
Zfish   628 KTSK---------------------------VKK------------------------------- 634

  Fly   904 IEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERR 968
                   :|.||..|..                                 ||::..||:..:...
Zfish   635 -------SSSFEDTDTD---------------------------------QESSSGASKAQAHHS 659

  Fly   969 KKERTARVAKEMSDLIIYFRSV--PFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQIS 1031
            :|::|.::::.:||| :|.:||  |..|...:..::||..||||. |..||....|:.:::.|:|
Zfish   660 RKKKTMKLSRALSDL-VYMKSVGMPDFESQGVTWQVSSMSETKAH-QLIQQKPVPFMRFNQRQLS 722

  Fly  1032 RVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSDSF 1096
            ||||...|:|||||||.||||.|..::|||||:..:.:|||:|||..||.||||.||..:...||
Zfish   723 RVYPSPYRVDSSNFNPQPFWNAGCHLVALNYQSEGRVLQLNRAKFYCNGNCGYIQKPGCLCEGSF 787

  Fly  1097 NP--NNPLCDGLSEVKVSIRLIAARHLFR--------GGKSNNPQIVVELIGASFDTGVKYRTKV 1151
            ||  .:|| .|..:.::.:::|:.:.|.:        .|:..:|.:.||:||...|...:....|
Zfish   788 NPVAEDPL-PGRLKKQLILKVISGQQLPKPKDSMLGDRGEIIDPFVEVEIIGLPVDCCKEQTRVV 851

  Fly  1152 NENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFS 1216
            ::|||||:|.|:..|.:..|:.|::||.|.|.|...: .||.|.......:..|||.|.|
Zfish   852 DDNGFNPMWEETLVFTLHMPENALIRFLVWDHDPIGQ-DFIGQRTIAFNSMIPGYRHVYL----- 910

  Fly  1217 EELELSSLLINIKIANVTA 1235
            |.:|.:|:.:::.:.::|:
Zfish   911 EGMEEASIFVHVAVNDITS 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	37/134 (28%)
		PI-PLCc_gamma	323..>470	CDD:176534	81/148 (55%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	10/97 (10%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	6/99 (6%)
		SH3_PLCgamma	828..880	CDD:212759	4/51 (8%)
		PLCYc	981..1091	CDD:128454	56/111 (50%)
		C2_PLC_like	1109..1215	CDD:175974	33/113 (29%)
plch2a	XP_009302541.1	PH_PLC_eta	86..192	CDD:270170	34/120 (28%)
		EFh	210..276	CDD:238008	15/84 (18%)
		EF-hand_7	211..272	CDD:290234	13/72 (18%)
		PLN02952	252..910	CDD:178538	262/1029 (25%)
		EF-hand_like	280..361	CDD:286375	19/85 (22%)
		PI-PLCc_GDPD_SF	362..770	CDD:301322	187/763 (25%)
		C2_PLC_like	800..924	CDD:175974	36/129 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586427
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750