DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and plcb3

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	XP_005166590.1	Gene:	plcb3 / 100001532	ZFINID:	ZDB-GENE-030616-594	Length:	1245	Species:	Danio rerio

Alignment Length:	1273	Identity:	296/1273 - (23%)
Similarity:	433/1273 - (34%)	Gaps:	529/1273 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LYGKQRRPDRRHLMLIRETRQLLWATVATQTP-----RTDYEG--------------AIQLREIR 76
            ::..|.:|...:.:|.|.::.:.|...|..||     |.|..|              .:.:..||
Zfish     8 VHALQLKPVSVNEVLKRGSKFIKWDEEANSTPSLITLRVDPNGFFLYWTGGTSMEAEILDMSHIR 72

  Fly    77 EIRVGKHSKEFR-------LFADDCQRFESSKCFVILHGNHFKLKSF-SVVALSEIEADNWVRGL 133
            :.|.||.:|..:       ||:........|:...:::||.....|| :..|:.:.....|...|
Zfish    73 DTRTGKFAKTPKDQRIREMLFSGKADGNSDSRLLTVVYGNDLVNISFLNFQAVQDGYCKLWTDEL 137

  Fly   134 RYMVKDTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGK 198
            ..:..:.|.                |..:.||...||..:...||| :|.|:.:..: .||.:.|
Zfish   138 FKLATNMLS----------------QNASRNTFLLKAYTKLKLQVT-QDGKIPVKNI-LKMFSDK 184

  Fly   199 -----FMEHFTEDVRRKHDLKFDDFS-RLYQKLLLPNGFASVLSGSGVANFPYSEDQQVV----- 252
                 .:||......|...:|.|||: .::|      .|.:.||       |..|.:::.
Zfish   185 KRVEMALEHCGLIFNRVDGIKPDDFTWEMFQ------NFLNKLS-------PRPEVERIFVDLGS 236

  Fly   253 --RP----AELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEPY-----------LTF 300
              :|    .:|..|:..:|||...:|:....:.       :|..|.:.|.|           ::.
Zfish   237 KGKPFLSLDQLMDFINRKQRDSRLNEVLYPPLK-------RDQVRQLMEKYETNTSQLERDQISL 294

  Fly   301 PEFVDFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGC 365
            ..|..:|..::|.:...:...:..|||.|||.|:|.||||||||..|.:..||.|.|.:.|..||
Zfish   295 MSFTKYLGGEENTVVPPERLDIIDDMNQPLSHYFINSSHNTYLTVGQLTGLSSVEMYRQVLLTGC 359

  Fly   366 RCIELDCWNG--PDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNC-SLEQQR 427
            ||||||||.|  |:..|.|.||.|:|::|.|.|||:.|.:.||.:|.||:|||.|.:. |.:||.
Zfish   360 RCIELDCWKGRPPEEEPIITHGFTMTTEIPFKDVIEAIAESAFKTSPYPLILSFENHVDSAKQQA 424

  Fly   428 NMAQALIEVFGDMLLTQPCDRNE----QHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGH 488
            .||:....:|||.||..|.|:..    |.||||.:|..||::|:||...               |
Zfish   425 KMAEYCRSMFGDALLIDPLDKYPLVPGQQLPSPQELLGKILIKNKKKHH---------------H 474

  Fly   489 RSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNS 553
            |:|.||            ::|:         ||..|:.               ||.:|:.   ..
Zfish   475 RASNGG------------SIRR---------KDGTDEQ---------------SSPLNDC---PL 500

  Fly   554 EDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHF-----GD 613
            .|.|.|     .|.||                          ||.|.|:.:.|.:.:.     ||
Zfish   501 SDGDVG-----QLMSN--------------------------GGEKLAERMAKDHDNSKSIDRGD 534

  Fly   614 GTFLVRESATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLR 678
            |.....|.
Zfish   535 GESDEEEE--------------------------------------------------------- 542

  Fly   679 SSEFSIILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINR 743
                    :||:|.||||        |.|.|..                :...:||
Zfish   543 --------EEPIPDPKKH--------NNTDEGT----------------AYSEVNA--------- 566

  Fly   744 KIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSG 808
                                .|.:.:|:||.            .||.
Zfish   567 --------------------TEEMSTLVNYI------------EPVK------------------ 581

  Fly   809 GHDDNGASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKH 873

Zfish   582 ----------------------------------------------------------------- 581

  Fly   874 LPANYVKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVI 938

Zfish   582 ----------------------------------------------------------------- 581

  Fly   939 GFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFREHSWIFQEMS 1003
                       .|:.:.||         :|||                            |.|||
Zfish   582 -----------FKSFEVAA---------KRKK----------------------------FFEMS 598

  Fly  1004 SFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKA 1068
            ||.|||.........|: |:.|::.|:||:||||.|:||||:.|..|||||.||:|||:||.|.|
Zfish   599 SFVETKGMDTLKNSPTE-FVEYNKKQMSRIYPKGTRVDSSNYMPQLFWNVGCQMVALNFQTLDLA 662

  Fly  1069 MQLNQAKFRNNGQCGYILKPSFMK--SDSFNP-NNPLCDGLSEVKVSIRLIAARHLFRGGKSNNP 1130
            ||||...|..||:|||:|||.||:  ...|:| ...:.||:....|.:::|:.:  |...|....
Zfish   663 MQLNMGVFEYNGRCGYLLKPEFMRRTDKHFDPFTTDIVDGIVANTVKVKIISGQ--FLNDKKVGV 725

  Fly  1131 QIVVELIGASFDTGVKYRTKV-NENGFNPVW-NESCEFN-VRNPQFAILRFEVQDEDMFAETHFI 1192
            .:.|::.|...||..|||||. |.|..:||| :|:..|| |..|..|.||..|.:|:    ..||
Zfish   726 YVEVDMFGLPADTKRKYRTKTSNNNSLDPVWDDETFVFNKVVLPTLASLRVAVYEEN----GKFI 786

  Fly  1193 AQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKI 1230
            .....|::.:|.||..:.|:|:.::.|.|.|||:..::
Zfish   787 GHRILPVSALRPGYHYICLKNELNQPLMLPSLLVYTEV 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	28/142 (20%)
		PI-PLCc_gamma	323..>470	CDD:176534	77/153 (50%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	9/102 (9%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	12/99 (12%)
		SH3_PLCgamma	828..880	CDD:212759	0/51 (0%)
		PLCYc	981..1091	CDD:128454	52/109 (48%)
		C2_PLC_like	1109..1215	CDD:175974	36/108 (33%)
plcb3	XP_005166590.1	PH_PLC_beta	22..151	CDD:270167	27/144 (19%)
		PLN02952	209..820	CDD:178538	248/1048 (24%)
		EF-hand_like	226..316	CDD:286375	15/96 (16%)
		PI-PLCc_beta	318..673	CDD:176533	173/766 (23%)
		C2_PLC_like	707..825	CDD:175974	41/124 (33%)
		DUF1154	922..957	CDD:284131
		DUF4456	<934..1051	CDD:291317
		PLC-beta_C	1014..1185	CDD:285865
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820