DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpC and CAPN13

DIOPT Version :10

Sequence 1:NP_573118.2 Gene:CalpC / 32597 FlyBaseID:FBgn0260450 Length:681 Species:Drosophila melanogaster
Sequence 2:NP_653176.2 Gene:CAPN13 / 92291 HGNCID:16663 Length:669 Species:Homo sapiens


Alignment Length:683 Identity:180/683 - (26%)
Similarity:287/683 - (42%) Gaps:132/683 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 CRSKNVLWEDPDFPAVQSSV---FYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVF-LNESA 72
            |.|....::|..|||..||:   ...:.......|||..||           ....|.| |::.:
Human    28 CLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDL-----------PGGPPHFILDDIS 81

  Fly    73 EFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAHGVFRFRLWWCGEWVEVLVDDRLP 137
            .||:..|...|.|.::.||.|:.......:::..........|:||||.|.||:||||::|||||
Human    82 RFDIQQGGAADCWFLAALGSLTQNPQYRQKILMVQSFSHQYAGIFRFRFWQCGQWVEVVIDDRLP 146

  Fly   138 TINGRLAFMQPQASNC-FWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILSDNIR 201
            ....:..|::|:..|. ||..|||||.|||.|||..|.||...|.|.||.|||:..:.:.|..: 
Human   147 VQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTGGVITNIHLHSSPV- 210

  Fly   202 PQTLKELLTTT---CIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMGDSVQLV 263
             ..:|.:.|.|   .::||......|    :.|:.|.||::....|.::..::::...|.. :::
Human   211 -DLVKAVKTATKAGSLITCATPSGPT----DTAQAMENGLVSLHAYTVTGAEQIQYRRGWE-EII 269

  Fly   264 CLKDTFSSKPFG-EKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFCDFVEIFSTMEV 327
            .|.:     |:| .:..:.|.||..|:.||......:::|.::...||||:|..||.:.|..|.:
Human   270 SLWN-----PWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKREDGEFWMSCQDFQQKFIAMFI 329

  Fly   328 -----VYLDTETSNDEEMLKSRPLH--WKMKMHQGQWKRGVTAGGCRNHESFHINPQLLISVQDE 385
                 :.||          ....||  |...|.:.|...|.||||.||...|:      .|||:.
Human   330 CSEIPITLD----------HGNTLHEGWSQIMFRKQVILGNTAGGPRNDAQFN------FSVQEP 378

  Fly   386 QD---LVIALNQHTAVEPKVIGFTMYTWDGEYML--------SECLQKDF-------FKNHVSYL 432
            .:   :|:.:.  .||.|.    .:...|.::.|        |:..::.|       |:|.|...
Human   379 MEGTNVVVCVT--VAVTPS----NLKAEDAKFPLDFQVILAGSQRFREKFPPVFFSSFRNTVQSS 437

  Fly   433 NSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMILLDPFPAL 497
            |:.:.....::|  ||..|:||::..|..  :.|.|.:||.                       |
Human   438 NNKFRRNFTMTY--HLSPGNYVVVAQTRR--KSAEFLLRIF-----------------------L 475

  Fly   498 KSTDAER----------CGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACL----PNDYI 548
            |..|::|          .|.|....  ..:.::.:.|.:...|:..:|..||...|    |.|..
Human   476 KMPDSDRHLSSHFNLRMKGSPSEHG--SQQSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMF 538

  Fly   549 KGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALCD 613
                ::|.||.::||.:...:||:..::|......|..:|.||:. .:...|:|.:..|..|:.:
Human   539 ----SLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQK-VQTSPGVLLSSDLWKAIEN 598

  Fly   614 IGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAV 646
            ..|     :....|.|.:....|||.||.|..|
Human   599 TDF-----LRGIFISRELLHLVTLRYSDSVGRV 626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpCNP_573118.2 CysPc 7..329 CDD:238004 99/330 (30%)
Calpain_III 346..483 CDD:238132 39/156 (25%)
EFh_PEF 515..680 CDD:355382 34/136 (25%)
EF-hand motif 515..543 CDD:320054 5/27 (19%)
EF-hand motif 556..585 CDD:320054 7/28 (25%)
EF-hand motif 586..615 CDD:320054 7/28 (25%)
EF-hand motif 622..650 CDD:320054 9/25 (36%)
EF-hand motif 652..680 CDD:320054
CAPN13NP_653176.2 Peptidase_C2 35..331 CDD:459889 97/318 (31%)
Calpain_III 347..474 CDD:469636 36/142 (25%)
EFh_PEF_CAPN13_14 501..669 CDD:320070 34/136 (25%)
EF-hand motif 501..529 CDD:320070 5/27 (19%)
EF-hand motif 542..571 CDD:320070 7/28 (25%)
EF-hand motif 572..605 CDD:320070 8/38 (21%)
EF-hand motif 611..639 CDD:320070 7/16 (44%)
EF-hand motif 641..669 CDD:320070
Blue background indicates that the domain is not in the aligned region.

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