DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and CAPN13

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_653176.2	Gene:	CAPN13 / 92291	HGNCID:	16663	Length:	669	Species:	Homo sapiens

Alignment Length:	683	Identity:	180/683 - (26%)
Similarity:	287/683 - (42%)	Gaps:	132/683 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CRSKNVLWEDPDFPAVQSSV---FYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVF-LNESA 72
            |.|....::|..|||..||:   ...:.......|||..||           ....|.| |::.:
Human    28 CLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDL-----------PGGPPHFILDDIS 81

  Fly    73 EFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAHGVFRFRLWWCGEWVEVLVDDRLP 137
            .||:..|...|.|.::.||.|:.......:::..........|:||||.|.||:||||::|||||
Human    82 RFDIQQGGAADCWFLAALGSLTQNPQYRQKILMVQSFSHQYAGIFRFRFWQCGQWVEVVIDDRLP 146

  Fly   138 TINGRLAFMQPQASNC-FWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILSDNIR 201
            ....:..|::|:..|. ||..|||||.|||.|||..|.||...|.|.||.|||:..:.:.|..:
Human   147 VQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTGGVITNIHLHSSPV- 210

  Fly   202 PQTLKELLTTT---CIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMGDSVQLV 263
             ..:|.:.|.|   .::||......|    :.|:.|.||::....|.::..::::...|.. :::
Human   211 -DLVKAVKTATKAGSLITCATPSGPT----DTAQAMENGLVSLHAYTVTGAEQIQYRRGWE-EII 269

  Fly   264 CLKDTFSSKPFG-EKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFCDFVEIFSTMEV 327
            .|.:     |:| .:..:.|.||..|:.||......:::|.::...||||:|..||.:.|..|.:
Human   270 SLWN-----PWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKREDGEFWMSCQDFQQKFIAMFI 329

  Fly   328 -----VYLDTETSNDEEMLKSRPLH--WKMKMHQGQWKRGVTAGGCRNHESFHINPQLLISVQDE 385
                 :.||          ....||  |...|.:.|...|.||||.||...|:      .|||:.
Human   330 CSEIPITLD----------HGNTLHEGWSQIMFRKQVILGNTAGGPRNDAQFN------FSVQEP 378

  Fly   386 QD---LVIALNQHTAVEPKVIGFTMYTWDGEYML--------SECLQKDF-------FKNHVSYL 432
            .:   :|:.:.  .||.|.    .:...|.::.|        |:..::.|       |:|.|...
Human   379 MEGTNVVVCVT--VAVTPS----NLKAEDAKFPLDFQVILAGSQRFREKFPPVFFSSFRNTVQSS 437

  Fly   433 NSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMILLDPFPAL 497
            |:.:.....::|  ||..|:||::..|..  :.|.|.:||.                       |
Human   438 NNKFRRNFTMTY--HLSPGNYVVVAQTRR--KSAEFLLRIF-----------------------L 475

  Fly   498 KSTDAER----------CGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACL----PNDYI 548
            |..|::|          .|.|....  ..:.::.:.|.:...|:..:|..||...|    |.|..
Human   476 KMPDSDRHLSSHFNLRMKGSPSEHG--SQQSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMF 538

  Fly   549 KGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALCD 613
                ::|.||.::||.:...:||:..::|......|..:|.||:. .:...|:|.:..|..|:.:
Human   539 ----SLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQK-VQTSPGVLLSSDLWKAIEN 598

  Fly   614 IGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAV 646
            ..|     :....|.|.:....|||.||.|..|
Human   599 TDF-----LRGIFISRELLHLVTLRYSDSVGRV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	99/330 (30%)
		Calpain_III	346..483	CDD:238132	39/156 (25%)
		FRQ1	<567..648	CDD:227455	21/80 (26%)
CAPN13	NP_653176.2	Peptidase_C2	35..331	CDD:279042	97/318 (31%)
CAPN13	NP_653176.2	Calpain_III	347..474	CDD:294111	36/142 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920