DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and CAPN3

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_000061.1	Gene:	CAPN3 / 825	HGNCID:	1480	Length:	821	Species:	Homo sapiens

Alignment Length:	792	Identity:	219/792 - (27%)
Similarity:	363/792 - (45%)	Gaps:	156/792 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLN 69
            :|::...|..|.||:.||:||..::|:||.|..|..|.|||..::.::            |.|:.
Human    61 FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICEN------------PRFII 113

  Fly    70 ESA-EFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLV 132
            :.| ..|:..|::||.|.::.:..|:..::|.:||:|.||:....: |:|.|:.|..||||:|::
Human   114 DGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVI 178

  Fly   133 DDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGV-----VRQ 192
            ||.|||.|.:|.|.:....|.||:||||||.|||||||||||.|..::.:.|..|||     :|.
Human   179 DDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRD 243

  Fly   193 MPILSDNIRPQTLKELLTTTCIVTCLADKSATV------AKKNLAE------------------- 232
            .|  ||..:  .:|:.:....::.|..|....:      :..|:.|
Human   244 AP--SDMYK--IMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDL 304

  Fly   233 --------------------RMPNGILVNVNYRLSSLDKVKTLMGDSVQLVCLKDTFSSKPFGEK 277
                                ||..|::....|.::.||:| ...|:.|:||.|::     |:|:
Human   305 DPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEV-PFKGEKVKLVRLRN-----PWGQ- 362

  Fly   278 THFLGDWSPMSKTWERVSQVERARLIRQL-GPGEFWLSFCDFVEIFSTMEVVYLDTETSNDEEML 341
            ..:.|.||...|.|..|.:.|:|||..|: ..||||:|:.||:..|:.:|:..|..:....:::.
Human   363 VEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQ 427

  Fly   342 KSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHINPQLLISVQDEQD----------LVIALNQH 395
            .     |.:.:::|:|.||.:||||||. ::|..|||..:.:.:|.|          .::||.|.
Human   428 T-----WTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQK 487

  Fly   396 TAVEPK-------VIGFTMYTWDGE-YMLSECLQKDFFKNHVSYLNS-DYGNTRHVSYHTHLEAG 451
            ...:.:       .|||.:|....| :...:.||||||..:.|...| .|.|.|.||....|...
Human   488 NRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPS 552

  Fly   452 HYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMILLD------------------------ 492
            .||::|:||||.:|..|.:|:.  ...|....|.:..|.:|
Human   553 EYVIVPSTYEPHQEGEFILRVF--SEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKEL 615

  Fly   493 ---------------------PFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELH 536
                                 |.|...|:|.|.      :...|:..::.|:|.::..|...||.
Human   616 GVDQESEEGKGKTSPDKQKQSPQPQPGSSDQES------EEQQQFRNIFKQIAGDDMEICADELK 674

  Fly   537 ELLEACL--PNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKA 599
            ::|...:  ..|.......::.||.:|||.|..|||::..|:|......:|:||.:||.|..:::
Human   675 KVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQS 739

  Fly   600 GILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQV 664
            |.:.:..:|:|:.|.||.|:..:.:.:..||..|...:....|:...:.|...|..||..:....
Human   740 GTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGD 804

  Fly   665 NVIEVHLHDWIK 676
            .:|::::.:|::
Human   805 GIIKLNVLEWLQ 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	117/374 (31%)
		Calpain_III	346..483	CDD:238132	50/156 (32%)
		FRQ1	<567..648	CDD:227455	22/80 (28%)
CAPN3	NP_000061.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	7..37
		Peptidase_C2	75..415	CDD:279042	113/362 (31%)
		Domain III	418..586		51/174 (29%)
		Calpain_III	429..579	CDD:279416	49/151 (32%)
		Calpain_u2	583..653	CDD:293254	8/75 (11%)
		Linker	587..649		7/67 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..652		5/48 (10%)
		Domain IV	650..821		42/167 (25%)
		EFh	653..721	CDD:238008	19/67 (28%)
		EFh	697..751	CDD:238008	19/53 (36%)
		EFh	728..817	CDD:298682	21/89 (24%)
		EF-hand_7	728..784	CDD:290234	15/55 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920