Protein Alignment CalpC and capn12

DIOPT Version :10

• Sequence 1: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: XP_005173727.1
• Gene: capn12 / 799247
• ZFINID: ZDB-GENE-050419-245
• Length: 717
• Species: Danio rerio
• Alignment Length: 738
• Identity: 206/738 - (27%)
• Similarity: 338/738 - (45%)
• Gaps: 101/738 - (13%)

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFY--YQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVF 67
            ||.:|..|....||:.|..|.|.|||:..  ...|....:|.|..::.   |.||....:....
Zfish    18 YEVLLQTCLKSAVLFSDSVFAANQSSLGLPADPDPKKAVKWLRPKEIT---SNAVFVEGTMGTT- 78

  Fly    68 LNESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVL 131
                   |:..|::|:.||::.|..|:....||.:||||.|:|:.:: |:|||:.|..||||||:
Zfish    79 -------DICQGQLGNCWLLAALSCLTMHPTLFVKVVPAGQSLSESYAGIFRFKFWQYGEWVEVV 136

  Fly   132 VDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPIL 196
            ||||||...|||.|...:.||.||:||:|||.|||.|||.:||.|..|:|:.|..||:...:|:.
Zfish   137 VDDRLPVREGRLLFSYSRTSNEFWSALVEKAYAKLIGSYGSLKGGIISEGMEDFTGGIAYSLPVS 201

  Fly   197 SDNIRP-----QTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLM 256
            |   ||     :.:...|....:::|.. .:.||  |::....|.|::....|.::...|||. .
Zfish   202 S---RPPRMLWKAITAALARNSLLSCFI-HATTV--KDIGTVTPEGLIKGHAYAITETGKVKK-A 259

  Fly   257 GDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARL-IRQLGPGEFWLSFCDFVE 320
            .:.|.|:.|::     |:| ...:.|.||...|.|:.|...|:.:| :.::..||||:|..||..
Zfish   260 SEEVFLLRLRN-----PWG-FVEYCGPWSDKCKDWDFVDNTEKTKLELAKVEDGEFWISIEDFCR 318

  Fly   321 IFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHINP--QLLISV 382
            .::|:|:..:|.::.:.||...:....|.:.:|||.|....:|||.|.: :||..||  |:::|.
Zfish   319 FYNTVEMCSVDPDSMSGEESEDTSTSSWTLSLHQGTWVPMCSAGGSRRYPKSFWKNPQYQMILSE 383

  Fly   383 QDEQD------------------------------------------LVIALNQHTAVEPKV--- 402
            :|..|                                          ||..|.::...:.||
Zfish   384 KDVDDHDYGEGEEGDDGGDGEEDEDVSLLPPVSKTSKPGEKKKKCTVLVELLQKYRRQKDKVNFL 448

  Fly   403 -IGFTMYTWDGEYMLSE-CLQKDFF-KNHVSYLNSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAE 464
             |.|.:|....|...|. .|.:.|| .|.....:..|.:.|.|....|||.|.||::.:||.|.:
Zfish   449 YIAFHIYKVPPELKDSPGSLDQQFFSSNRAISRSGKYRSIRSVWRKVHLEPGSYVILASTYRPNQ 513

  Fly   465 EAHFTVRILGTGSFRLSCLETQTMILLDPFPALKSTDAERCGGPKVKSVCQY--EPVYMQLADEN 527
            :..|.:||.         .:|..:.....||...:..|.....| |....||  :..:.:.|..:
Zfish   514 QGEFFLRIY---------TKTGNIQGFQDFPCTNNYSAMVMSKP-VLPEDQYRVQKWFEEKAGSD 568

  Fly   528 KTINCFELHELLEACLPNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFK 592
            :.:|..:...|:.:.|..||.   ..::.|||:|..:|..|.||:...|.:..:.:|::.|.:|.
Zfish   569 ERVNAVQFMNLVNSVLEKDYE---LPLETCRQLIFGEDTGGRGRLDRAQAEKLLSSLRNLQSIFF 630

  Fly   593 MYTKEKAGILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFH 657
            .:.::.:|.:....|..||...|.:..:.::..|.:|:...:..|....|||.|..|...|:.:.
Zfish   631 QFDEDSSGTMSPFELSLALNAAGVECDSVVVQMLWERFGAGEQYLPFYGFVSCVARLQVLFDLYE 695

  Fly   658 LKNYGQVNVIEVHLHDWIKSILS 680
            .:...:|.  :..::.|:..:|:
Zfish   696 AETNQEVK--DKGINAWLLKLLA 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	112/330 (34%)
		Calpain_III	346..483	CDD:238132	46/187 (25%)
		EFh_PEF	515..680	CDD:355382	36/166 (22%)
		EF-hand motif	515..543	CDD:320054	5/29 (17%)
		EF-hand motif	556..585	CDD:320054	9/28 (32%)
		EF-hand motif	586..615	CDD:320054	6/28 (21%)
		EF-hand motif	622..650	CDD:320054	7/27 (26%)
		EF-hand motif	652..680	CDD:320054	3/27 (11%)
capn12	XP_005173727.1	Peptidase_C2	32..327	CDD:459889	108/318 (34%)
		Calpain_III	351..522	CDD:460050	44/170 (26%)
		EFh_PEF_Group_II_CAPN_like	556..715	CDD:320057	34/163 (21%)
		EF-hand motif	556..584	CDD:320057	3/27 (11%)
		EF-hand motif	594..623	CDD:320057	9/28 (32%)
		EF-hand motif	624..654	CDD:320057	6/29 (21%)
		EF-hand motif	660..688	CDD:320057	7/27 (26%)
		EF-hand motif	690..715	CDD:320057	3/26 (12%)