DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and Capn9

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_006531467.1	Gene:	Capn9 / 73647	MGIID:	1920897	Length:	718	Species:	Mus musculus

Alignment Length:	728	Identity:	220/728 - (30%)
Similarity:	348/728 - (47%)	Gaps:	101/728 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVF-L 68
            :|::...|.....|:||.||||...|:||.:.|...|.|||..::.:.            |.| |
Mouse    29 FEQLRQGCLQSGTLFEDADFPASNVSLFYSERPQVPFVWKRPGEIVEK------------PEFIL 81

  Fly    69 NESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLV 132
            ..:...|:..|::||.||::.:..|:..:....||||.||...|.: |:|.|:.|...||::|::
Mouse    82 GGATRTDICQGELGDCWLLAAIASLTLNQKALTRVVPQDQGFGSGYAGIFHFQFWQHSEWLDVVI 146

  Fly   133 DDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGV-----VRQ 192
            ||||||...||.|:.....|.||:||||||.|||:|||||||.|:..:.:.|..|||     :|:
Mouse   147 DDRLPTFKDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAENFQIRE 211

  Fly   193 MPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMG 257
            .|.....|..:.||......|.:..| :.|.:.|:.:|      |::....|.::.||:| ...|
Mouse   212 APEDFFEILEKALKRGSLLGCSIDTL-NASESEARTSL------GLIKGHAYTVTGLDQV-NFHG 268

  Fly   258 DSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARL-IRQLGPGEFWLSFCDFVEI 321
            ..::|:.:::     |:|: ..:.|.||..|..|..|...|:.|| ...|..||||::|.||...
Mouse   269 QRIKLIRVRN-----PWGQ-VEWNGPWSDSSPEWRSVDLEEQKRLGHTALDDGEFWMAFKDFKIH 327

  Fly   322 FSTMEVVYLDTETSNDEEMLKSRPLH-WKMKMHQGQWKRGVTAGGCRNH-ESFHINPQLLISVQD 384
            |..:|:..|..:.      |:...|| |::.:|||.|.||.|||||||. ::|..|||:.:|:.:
Mouse   328 FDKVEICNLTPDA------LEDSALHRWEVTIHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTE 386

  Fly   385 EQD------LVIALNQHTAVEPKVIGFTMYTWDGEYMLSEC------LQKDFFKNHVSYLNS-DY 436
            ..:      .:.||.|......|..|..|.|..  |.:.:|      |.:|||:.|.|...| .:
Mouse   387 RDEGQEGCTFLAALMQKDRRRLKRFGANMLTIG--YAIYQCPDKDGHLSRDFFRYHASLARSKTF 449

  Fly   437 GNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMI----LLDPFPAL 497
            .|.|.||....|..|.|:|||:|:||.:||.|.:||..........|:....|    |..|.|..
Mouse   450 INLREVSERFQLPPGDYILIPSTFEPHQEADFCLRIFSEKRAVTRDLDENIDIDLPELPKPTPQE 514

  Fly   498 KSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLPNDYIKGCANIDI--CRQV 560
            :.|:.|:          |:..::.::|.|:..::..||..:|.|.|..........:.:  ||.:
Mouse   515 EETEEEQ----------QFRALFQRVAGEDMEVSAEELEYVLNAVLQKKTALKFKRLSLLSCRNI 569

  Fly   561 IALQDRSGSGRITFQQFKTFMVNLKSW----------------------------QGVFKMYTKE 597
            |:|.|.||:|::.|::|:.|...||.|                            |.:|..:..:
Mouse   570 ISLMDTSGNGKLEFEEFRVFWDKLKHWMKAAVTPGQLPAATGPWALTSPCSTPWSQDLFLQFDVD 634

  Fly   598 KAGILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYG 662
            |:|.:.:..||.||...||||...::..::.||..:|..|...|:::.::.|..|...|...:..
Mouse   635 KSGTMSSYELRTALKAAGFQLGGHLLQLIVLRYADEDLQLDFDDYLNCLVRLENASRVFQSLSVK 699

  Fly   663 QVNVIEVHLHDWI 675
            ..:.|.::::::|
Mouse   700 NKDFIHLNINEFI 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	111/329 (34%)
		Calpain_III	346..483	CDD:238132	55/151 (36%)
		FRQ1	<567..648	CDD:227455	26/108 (24%)
Capn9	XP_006531467.1	Peptidase_C2	43..335	CDD:366222	109/317 (34%)
		Calpain_III	347..496	CDD:238132	54/150 (36%)
		EFh_PEF	523..718	CDD:355382	43/190 (23%)
		EF-hand motif	523..550	CDD:320054	6/26 (23%)
		EF-hand motif	565..594	CDD:320054	11/28 (39%)
		EF-hand motif	595..653	CDD:320054	9/57 (16%)
		EF-hand motif	659..687	CDD:320054	5/27 (19%)
		EF-hand motif	689..718	CDD:320054	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920