DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and zgc:136872

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001035341.1	Gene:	zgc:136872 / 678524	ZFINID:	ZDB-GENE-060421-5204	Length:	693	Species:	Danio rerio

Alignment Length:	711	Identity:	191/711 - (26%)
Similarity:	334/711 - (46%)	Gaps:	97/711 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVF---YYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPV 66
            ::::...|..:.:.:.|..||....|:.   ..:...:...|||..:|..:            ||
Zfish    34 FQQLKQFCLKERLRFRDNLFPPELKSIGLGPLKRDDLWKVVWKRPYELVPN------------PV 86

  Fly    67 FLNE-SAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVE 129
            ::.: ::.||.:.|::|:.|.::.:|.|:..:.:..:|:..|||.:..: |:|.||.|..|.||:
Zfish    87 YIAQGTSRFDFIQGRLGNCWFLASVGALTFQKRIMKQVIQDDQTFSVDYAGIFHFRFWRFGSWVD 151

  Fly   130 VLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGG--VVRQ 192
            |::||:||||:.:|.|:|.:..|.||.||||||.||:.|||..:..|..|:.|.|..||  :..:
Zfish   152 VVIDDKLPTIDNQLVFVQSKTPNEFWPALLEKAYAKVCGSYADMDAGNISEALMDFTGGPHMTIK 216

  Fly   193 MPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMG 257
            :...||.:. ..::....:..::.|..........:|..  :|||::....|.::.:.:| ...|
Zfish   217 LSQASDKLW-DIMRRAGQSESLMGCGTPGGQAGVLQNTV--LPNGLVEMHAYTVTGVTEV-VCKG 277

  Fly   258 DSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFCDFVEIF 322
            ..|:||.:.:.:.|   ||...   |||..|..||.| :.|..:....|..||||:|..||...|
Zfish   278 RPVKLVRIFNPWGS---GEWNR---DWSDRSPLWELV-RPEDQKYNDVLDNGEFWMSMEDFCRNF 335

  Fly   323 STMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHINPQLLI----SV 382
            |.|::...|...     :..|:...||.::|:|||..|.|||||.|. :||..|||..:    :|
Zfish   336 SEMDICCSDVNV-----LAGSQSSSWKTEVHKGQWVMGTTAGGCSNDIDSFSKNPQYRVTLKETV 395

  Fly   383 QDEQD-----LVIAL-------NQHTAVEPKVIGFTMYTWDGEYMLSECLQK---DFFKN-HVSY 431
            :|.:|     |:::|       |:|.|.... |||.:|.....  |.:..:|   .||:| .|..
Zfish   396 EDPRDKSSANLLVSLIQKSHKRNRHLATNFH-IGFNIYEVPAH--LKDQKEKFPASFFRNVRVVG 457

  Fly   432 LNSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMILLDPFPA 496
            .|..:.|.|.|......:||.|:::|:|::|.|.:.|.:.:..         :|:|:|
Zfish   458 KNESFLNAREVMEFFRFKAGDYLIVPSTFQPNEASSFLLTVYS---------KTETII------- 506

  Fly   497 LKSTDAERCGGPKVKSVCQYE----PVYMQLADENKTINCFELHELLEACLPNDYIKGCA--NID 555
               .|....|..:.|.:.:..    .:::|.||:...::...|.:||...|.....:...  ::|
Zfish   507 ---EDTSGYGITRTKMIPRDNDESFQLFLQYADKYGEVDAERLQKLLNENLHAGRSQKTTGFSVD 568

  Fly   556 ICRQVIALQDRSGSGRITFQQFKTFMVNLKSW------QGVFKMYTKEKAGILRAERLRDALCDI 614
            :|:.::||.|.|.:||::  :|:.    |:.|      :.:|........|.|....||:||...
Zfish   569 LCKSLVALMDLSVTGRLS--EFEC----LRLWKRAVFLKDIFYDMDVSHTGSLSVNELRNALKVA 627

  Fly   615 GFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWI 675
            ||.||..::|.:..||...:|.:.|.:|:..|:.:......|...:.|..|:: :..::|:
Zfish   628 GFVLSDGMLNLMALRYADSNGEISLENFIVLVLRMDCMAKTFKRLSAGGPNMM-LGENEWM 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	95/328 (29%)
		Calpain_III	346..483	CDD:238132	48/157 (31%)
		FRQ1	<567..648	CDD:227455	24/86 (28%)
zgc:136872	NP_001035341.1	Peptidase_C2	48..341	CDD:279042	94/315 (30%)
		Calpain_III	356..504	CDD:279416	49/159 (31%)
		EFh	600..659	CDD:298682	17/58 (29%)
		EF-hand_7	600..656	CDD:290234	16/55 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920