DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpC and SRI

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_003121.1	Gene:	SRI / 6717	HGNCID:	11292	Length:	198	Species:	Homo sapiens

Alignment Length:	181	Identity:	47/181 - (25%)
Similarity:	89/181 - (49%)	Gaps:	12/181 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 GGPKVKSVCQYEPVY---MQLADENKTINCFELHELLEACLPNDYIKG---CANIDICRQVIALQ 564
            |||......| :|:|   ..:|.::..|:..|    |:.||....|.|   ..|::.||.::::.
Human    23 GGPAFPGQTQ-DPLYGYFAAVAGQDGQIDADE----LQRCLTQSGIAGGYKPFNLETCRLMVSML 82

  Fly   565 DRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALCDIGFQLSTDIMNCLIQR 629
            ||..||.:.|.:||.....|..|:..|..:..:::|.:..:.|:.||..:||:||...:|.:.:|
Human    83 DRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKR 147

  Fly   630 YIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWIKSILS 680
            | ..:|.:...|:::..:.|....:.|..::..|..|:.....|:|:.::|
Human   148 Y-STNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMS 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004
		Calpain_III	346..483	CDD:238132
		FRQ1	<567..648	CDD:227455	21/80 (26%)
SRI	NP_003121.1	EFh_PEF_sorcin	34..198	CDD:320062	43/169 (25%)
		EF-hand motif	34..62	CDD:320062	8/31 (26%)
		EF-hand motif	74..103	CDD:320062	9/28 (32%)
		EF-hand motif	104..133	CDD:320062	6/28 (21%)
		EF-hand motif	140..167	CDD:320062	5/27 (19%)
		EF-hand motif	169..197	CDD:320062	5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910