DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and Capn12

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001104277.1	Gene:	Capn12 / 60594	MGIID:	1891369	Length:	720	Species:	Mus musculus

Alignment Length:	721	Identity:	197/721 - (27%)
Similarity:	310/721 - (42%)	Gaps:	132/721 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFT-----FQWKRIMDLADSGSGAVAANSSAA 64
            ||.|...|....:|:.||.|||...::.|.:..|.:     .:|||..:..            |.
Mouse    32 YEAIRRACLDSGILFRDPCFPAGPDALGYDKLGPDSEKAKGVEWKRPHEFC------------AE 84

  Fly    65 PVFLNES-AEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEW 127
            |.|:.|. :..||..|.:|:.||::....|:....|.|||||..|.....: |||.|:||..|.|
Mouse    85 PQFICEDMSRTDVCQGSLGNCWLLAAAASLTLYPRLLYRVVPPGQGFQDGYAGVFHFQLWQFGRW 149

  Fly   128 VEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGV--- 189
            |:|:|||:||...|:|.|::.:..|.|||.|||||.||||||||.::.|..::...|..|||
Mouse   150 VDVVVDDKLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEV 214

  Fly   190 --VRQ-MPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDK 251
              :|| .|.:...:|....||.|..   .|.|:|:...        |...|::....|.::...|
Mouse   215 LYLRQNTPGVFAALRHALAKESLVG---ATALSDRGEI--------RTDEGLVKGHAYSVTGTHK 268

  Fly   252 VKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFC 316
            : :|....|:|:.|::     |:| :..:.|.||.....|:.:....|..|:.:...||||:...
Mouse   269 M-SLGFTKVRLLRLRN-----PWG-RVEWSGPWSDSCPRWDMLPSEWRDALLVKKEDGEFWMELQ 326

  Fly   317 DFVEIFSTMEVVYLDTETSNDEEMLKSRPL--HWKMKMHQGQWKRGVTAGGCR-NHESFHINPQL 378
            ||:..|:|:::..|      ..|:|...|.  .|.:.:.||:|.||..:||.: :.|:|..|||.
Mouse   327 DFLTHFNTVQICSL------SPEVLGPSPAGGGWHIHIFQGRWVRGFNSGGSQPSAENFWTNPQF 385

  Fly   379 ---LISVQDEQD-----------------------------LVIALNQHT--AVEPK-----VIG 404
               |:...:|:|                             ::::|.|..  .:..|     .:|
Mouse   386 RLTLLEPDEEEDDDDEEGPWGGWGAAGARGPARGGRVPKCTVLLSLIQRNRRCLRAKGLTYLTVG 450

  Fly   405 FTMY--------TWD---GEYMLSECLQKDFFKNHVSYLNSDYGNTRHVSYHTHLEAGHYVLIPT 458
            |.::        .||   ...:|...|:.|         .|.:...|.||....|..|||:::|:
Mouse   451 FHVFQIPEELLDLWDSPRSRALLPGLLRAD---------RSVFCARRDVSRRCRLPPGHYLVVPS 506

  Fly   459 TYEPAEEAHFTVRILGTGSFRLSCLETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQL 523
            .....:||.||:||....|        .|.:.:|.   :.|.|.:....|......:...::::|
Mouse   507 ASRVGDEADFTLRIFSERS--------HTAVEIDD---VISADLDALQAPYKPLELELAQLFLEL 560

  Fly   524 ADENKTINCFELHEL----LEACLPNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNL 584
            |.|.:.:|..:|..|    ||....|....|...:..|.|::....|  ..|::...|:....:|
Mouse   561 AGEEEELNALQLQTLISIALEPARANTRTPGEIGLRTCEQLVQCFGR--GQRLSLHHFQELWGHL 623

  Fly   585 KSWQGVFKMYTKEKAGILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRL--SDFVSAVI 647
            .|||..|..:.::.:|.:.:..||.||...||.|:..:...|..||  :|..||:  ..||....
Mouse   624 MSWQATFDKFDEDASGTMNSCELRLALTAAGFHLNNQLTQSLTSRY--RDSRLRVDFERFVCCAA 686

  Fly   648 HLTTAF 653
            .||..|
Mouse   687 RLTCIF 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	105/334 (31%)
		Calpain_III	346..483	CDD:238132	42/189 (22%)
		FRQ1	<567..648	CDD:227455	23/82 (28%)
Capn12	NP_001104277.1	Peptidase_C2	46..339	CDD:279042	102/322 (32%)
		Domain III	342..541		49/218 (22%)
		Calpain_III	352..531	CDD:238132	43/195 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..415		2/21 (10%)
		Domain IV	542..720		40/155 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920