DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and capn2b

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001018177.1	Gene:	capn2b / 563053	ZFINID:	ZDB-GENE-050522-84	Length:	696	Species:	Danio rerio

Alignment Length:	716	Identity:	204/716 - (28%)
Similarity:	338/716 - (47%)	Gaps:	90/716 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASKY-----ERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQ-----WKRIMDLADSGSGA 56
            |:||     |.:.|:||::..|:.||.|||...|:.:.:..|.:.:     |||..:|...
Zfish    24 ATKYLNQDFEALRSECRARGTLFSDPTFPAAPESLGFKELGPNSSKTRGLVWKRPGELCQK---- 84

  Fly    57 VAANSSAAPVFL-NESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRF 119
                    |.|: ..:.:.|:..|.:||.||::.:..|:...::..||||..|.....: |:|.|
Zfish    85 --------PRFIVGGATKTDICQGALGDCWLLAAIASLTQNEDVLARVVPNGQEFDGTYAGIFHF 141

  Fly   120 RLWWCGEWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTD 184
            :.|..||||:|::|||||..:|.|.|:.....|.||:||||||.||::|.||||..|:.|:|..|
Zfish   142 QFWQFGEWVDVVIDDRLPVKDGELLFVYSAEKNEFWSALLEKAYAKVNGCYEALSGGSTSEGFED 206

  Fly   185 LLGGV-----VRQMPILSDNIRPQTLK--ELLTTTCIVTCLADKSATVAKKNLAERMPNGI--LV 240
            ..||:     :|:.|.....|..:.|:  .||..:..:|..||..| :.::.|.:.....:  ..
Zfish   207 FTGGIAESYEIRKAPTNLFQIIQKALEAGALLGCSIDITSAADSEA-ITRQKLVKGHAYSLTGAT 270

  Fly   241 NVNYRLSSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQ 305
            .||||           |...:||.:::     |:|: ..:.|.||..|..|..|:..||.....:
Zfish   271 EVNYR-----------GRKEKLVRMRN-----PWGQ-VEWTGAWSDNSPEWNSVAASERPDASAE 318

  Fly   306 LGPGEFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNHE 370
              .||||::|.:|:..:|.:|:..|..:...|:.:     .||.:..|.|.|:||.|||||||:.
Zfish   319 --DGEFWMAFSEFLTNYSRIEICTLTPDAITDDSV-----KHWAVTNHDGTWRRGSTAGGCRNNP 376

  Fly   371 -SFHINPQLLISVQDEQ--------DLVIALNQ-------HTAVEPKVIGFTMYTWDGEY--MLS 417
             :|.:|||.::.:.:|.        ..|:.|.|       .|..:...|||.:|....|:  ...
Zfish   377 YTFWMNPQFVVKLDEENVEDKEKGCSFVVGLIQKNRRRLRKTGEDMNTIGFAIYELPQEFHGQRE 441

  Fly   418 ECLQKDFFKNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLS 481
            ..|.|:||..|.....|: :.|.|.|....||..|.|:::|:|:|..::..|.:|:....
Zfish   442 VHLDKNFFLTHGQKARSETFINLREVCTRFHLPPGEYLIVPSTFEANKDGDFCLRVFSES----- 501

  Fly   482 CLETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLP-- 544
              :::|....||..|  ....|.....:|.|  ::..::::||..:..|:..||..:....:.
Zfish   502 --QSETQHCDDPVDA--ELPDETVSDDQVDS--KFRGMFVKLAGPDMEISPLELMTIFNKIIAKR 560

  Fly   545 NDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRD 609
            .|.......:|.||.::.|.|.||:|::...:|.|....::.:..:||....:.:|.:....||.
Zfish   561 TDIKSSTFTLDTCRVMVNLMDDSGNGKLGLGEFATLWKKVQRYLEIFKHNDLDSSGTISTPELRM 625

  Fly   610 ALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDW 674
            ||.:.||.|:..:...::.||..||.||...:|||.::.|...|..|...:..:...||::.:.|
Zfish   626 ALKEAGFCLNNTLFQLMVARYAEKDMTLLFDNFVSCLMRLEMMFRAFKRLDPHKSGFIELNFNQW 690

  Fly   675 I 675
            :
Zfish   691 L 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	104/337 (31%)
		Calpain_III	346..483	CDD:238132	46/155 (30%)
		FRQ1	<567..648	CDD:227455	24/80 (30%)
capn2b	NP_001018177.1	Peptidase_C2	46..339	CDD:279042	100/324 (31%)
		Calpain_III	354..503	CDD:279416	45/155 (29%)
		EFh	573..628	CDD:238008	15/54 (28%)
		FRQ1	601..>686	CDD:227455	24/84 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920