DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpC and si:ch211-202f3.4

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_009291546.1	Gene:	si:ch211-202f3.4 / 560088	ZFINID:	ZDB-GENE-131120-116	Length:	523	Species:	Danio rerio

Alignment Length:	532	Identity:	143/532 - (26%)
Similarity:	244/532 - (45%)	Gaps:	88/532 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSV-FYYQTPP----FTFQWKRIMDLADSGSGAVAANSSAA 64
            |:.:...|.:::.|:.|..||...||: .:.:.||    ....|||..:|.           |..
Zfish    30 YQELQQKCLTESTLYSDELFPPDNSSIGLFDEVPPEVDMSQIVWKRPSELV-----------SDP 83

  Fly    65 PVFLNESAEFDVVPGK-MGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEW 127
            .:.:::.:.||...|. :|:.|.::.:|.|:..:::..:|:||:|:....: |:|.||.|...:|
Zfish    84 NLIVDDVSRFDYAQGSVLGNCWFLASIGALTFEKDIMKQVLPAEQSFTKDYAGIFHFRFWRFEKW 148

  Fly   128 VEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQ 192
            ::|::||:||||:..|.|:..:.||.||.||||||.||:.|||..|..|..|:.|.|..||....
Zfish   149 IDVVIDDQLPTIDDELLFVCSKTSNEFWPALLEKAYAKVCGSYADLNAGFISEALMDFTGGTHMY 213

  Fly   193 MPILSDNIRPQTLKELL----TTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVK 253
            ..:.|   .|..|.:::    .:..::.|.::...:..:..|.    :||:.:..|.::.:.:|.
Zfish   214 YTLSS---APADLWKIMECAFISKTLIGCGSNSEGSPEENELL----HGIIADHAYTVTGVFEVI 271

  Fly   254 TLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFCDF 318
            : ..:.||||.|.:     |:||: .:.||||..|..||.|.:..|......|..||||:|..||
Zfish   272 S-EENPVQLVRLLN-----PWGEE-EWQGDWSDESPLWETVCEEARKCCREVLNDGEFWMSMEDF 329

  Fly   319 VEIFSTMEVV-----YLDTETSNDEEMLKSRPLHWKMKMHQGQWK----------RGVTAGG-CR 367
            ..:|.::::.     :||          .|...||..|.|.|:|.          ..:|||| ..
Zfish   330 TRLFESIDICCLCPDFLD----------GSSDCHWTSKRHFGRWNAEKFMYNTFIHHLTAGGDII 384

  Fly   368 NHESFHINPQLLISV----------QDEQDLVIALNQH------TAVEPKVIGFTMYTWDGEYML 416
            ..|:|..|||..:::          |..::::::|.|:      .:.|...|||.::    |..|
Zfish   385 KTETFWKNPQFRVTIDELNEDCASGQRPENILVSLMQNHEKRNRNSQENYDIGFYVF----EIPL 445

  Fly   417 -----SECLQKDFFKNHVSYLNS-DYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGT 475
                 :|....:||.:.....:: |....|.|.....||.|.|:::|.|..|.|.|.|.:.:...
Zfish   446 EMRHQNERFAMEFFADREPVAHTDDLVWLREVMKFFRLEPGEYLIVPCTKNPGETASFVLSVFSK 510

  Fly   476 GSFRLSCLETQT 487
            ....|..::..|
Zfish   511 HETHLEQIQETT 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	97/337 (29%)
		Calpain_III	346..483	CDD:238132	41/169 (24%)
		FRQ1	<567..648	CDD:227455
si:ch211-202f3.4	XP_009291546.1	Peptidase_C2	44..339	CDD:279042	95/319 (30%)
si:ch211-202f3.4	XP_009291546.1	Calpain_III	354..513	CDD:279416	39/162 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920