DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and adgb

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_009293055.1	Gene:	adgb / 555435	ZFINID:	ZDB-GENE-041001-205	Length:	1473	Species:	Danio rerio

Alignment Length:	422	Identity:	90/422 - (21%)
Similarity:	148/422 - (35%)	Gaps:	117/422 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASKYERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPV 66
            |.|::...:...||  |::||:......|.....|      |||..:..          ....||
Zfish    58 AEKWDAPKTPKDSK--LFDDPEGKVELPSSLRIHT------WKRPSEFI----------LKKIPV 104

  Fly    67 FLNESAEFDVVPGK--------MGDRWLVSCLGLLSSLRNLFYRVVPADQT-------------- 109
            .:..:..||:....        |  ||::|...:|..:.|.....|.:.:|
Zfish   105 VVENADTFDLTSANEHLFSSELM--RWIISECHILWKVCNTREDKVVSTETVPTLWKPWEHIYSL 167

  Fly   110 ---------LASAHGVFRFRLWWCGEWVEVLVDDRLPTINGRLAFMQPQASNC--FWAALLEKAI 163
                     |.:.:|.:..:|:|.|.|.::.|||.|| .:.....:.|..:|.  .|..||.|.|
Zfish   168 CKAGKDHMPLYNTYGKYVIKLYWLGSWRKITVDDMLP-FDKDNNLLLPATTNQSELWPMLLAKGI 231

  Fly   164 AKLHGSYEALKYGTRSDG----LTDLLGGVVRQMPI-----------LSDNIRPQTLKE------ 207
            .|:..:...:....|..|    :..|.|.:...:|:           |.||:....|:|
Zfish   232 LKVASTDTPVSGSGREFGEFTIIHCLTGWIPEMIPLKSWYTGKIWDFLRDNVAQFQLEEESSEEK 296

  Fly   208 LLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYR-LSSLDK---VKTLMGDS--------- 259
            :..|...|..:..||   .|......:|. |:|..:|: |..::|   :.|.|.||
Zfish   297 ITITDSNVNNVQSKS---PKSRATGSVPQ-IVVCASYQPLHLMEKRTSMLTRMADSSESLRQYGL 357

  Fly   260 -------VQLVCLKDTFSSKPFGEKTHFLGDWS---PMSKTWERVSQVERARLIRQLGPGEFWLS 314
                   |.|.|.:|.....|  .||..|..|.   |..:|  .::...:...:::  |.:
Zfish   358 SQLFSHPVLLTCTRDCPLVAP--PKTPPLPQWKLIRPRKQT--NITDEPKEPPVQK--PEQ---- 412

  Fly   315 FCDFVEIFSTMEVVYLDTETSNDEEM--LKSR 344
               |:|:.|......|.|.:::|.|.  ||.|
Zfish   413 ---FIEVSSPFINFKLMTMSAHDMEHGGLKKR 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	81/398 (20%)
		Calpain_III	346..483	CDD:238132
		FRQ1	<567..648	CDD:227455
adgb	XP_009293055.1	CysPc	72..>269	CDD:294044	44/215 (20%)
adgb	XP_009293055.1	Globin_like	<716..803	CDD:304364
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900