DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpC and PEF1

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_036524.1	Gene:	PEF1 / 553115	HGNCID:	30009	Length:	284	Species:	Homo sapiens

Alignment Length:	154	Identity:	35/154 - (22%)
Similarity:	68/154 - (44%)	Gaps:	7/154 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 ADENKTINCFELHELLEACLPNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQ 588
            :|.:..|:..||.:.|..|..:.:     |.:.|..:|.:.|::.||||....|......::.|:
Human   128 SDHSGYISMKELKQALVNCNWSSF-----NDETCLMMINMFDKTKSGRIDVYGFSALWKFIQQWK 187

  Fly   589 GVFKMYTKEKAGILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDG--TLRLSDFVSAVIHLTT 651
            .:|:.|.::::|.:....|:.||..:|:.||......|:.||..:..  .::|..|:.....|..
Human   188 NLFQQYDRDRSGSISYTELQQALSQMGYNLSPQFTQLLVSRYCPRSANPAMQLDRFIQVCTQLQV 252

  Fly   652 AFNQFHLKNYGQVNVIEVHLHDWI 675
            ....|..|:......|.:...|::
Human   253 LTEAFREKDTAVQGNIRLSFEDFV 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004
		Calpain_III	346..483	CDD:238132
		FRQ1	<567..648	CDD:227455	20/82 (24%)
PEF1	NP_036524.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..111
		9 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-P. /evidence=ECO:0000305	21..109
		EFh_PEF_peflin	118..283	CDD:320059	35/154 (23%)
		EF-hand motif	118..147	CDD:320059	5/18 (28%)
		EF-hand motif	155..184	CDD:320059	8/28 (29%)
		EF-hand motif	185..215	CDD:320059	7/29 (24%)
		Required for interaction with PDCD6. /evidence=ECO:0000269\|PubMed:11883899	204..284		16/73 (22%)
		EF-hand motif	221..251	CDD:320059	5/29 (17%)
		EF-hand motif	252..283	CDD:320059	4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910