Protein Alignment CalpC and capn1

DIOPT Version :10

• Sequence 1: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001013632.1
• Gene: capn1 / 541455
• XenbaseID: XB-GENE-990196
• Length: 713
• Species: Xenopus tropicalis
• Alignment Length: 714
• Identity: 196/714 - (27%)
• Similarity: 330/714 - (46%)
• Gaps: 81/714 - (11%)

  Fly     1 MASKYERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPP-----FTFQWKRIMDLADSGSGAVAAN 60
            :...|:|||.:|.....|::|..||....|:.:.:..|     :..:|.|...|..:
 Frog    38 LGQDYDRILHECLQNRTLFKDDTFPPSAYSLGFKELGPNSSKTYGVKWVRPSQLVSN-------- 94

  Fly    61 SSAAPVFLNESA-EFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWW 123
                |.|:.:.| ..|:..|.:||.||::.:..|:....:.:||||..|:....: |||.|:||.
 Frog    95 ----PQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTILHRVVPHGQSFQDNYAGVFHFQLWQ 155

  Fly   124 CGEWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGG 188
            .||||:|::||.||..:|:|.|:...:.|.||:||||||.||.:|.||||..|:.|:|..|..||
 Frog   156 FGEWVDVVIDDYLPVKDGKLVFVHSASGNEFWSALLEKAYAKANGCYEALSGGSTSEGFEDFTGG 220

  Fly   189 V-----VRQMP--ILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRL 246
            |     :::.|  :.|..::......|:..:..:|...|..|...||         ::....|.:
 Frog   221 VTEWYEMKKAPKDLFSIIMKAVERGSLMGCSIDITSATDMEAVTFKK---------LVKGHAYSV 276

  Fly   247 SSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEF 311
            :...:: ...|.|.:|:.:::     |:|| ..:.|.||..|..|..|...:...|..::..|||
 Frog   277 TGAKEI-NFRGRSQKLIRMRN-----PWGE-VEWTGAWSDNSSEWNSVDAADSQDLRIKMEDGEF 334

  Fly   312 WLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHIN 375
            |::|.||:..||.:|:..|..:.....:..|     |...:..|.|::|.|||||||. .:|.||
 Frog   335 WMAFEDFLREFSRLEICNLTPDALTARKYRK-----WNTTVFNGNWRKGSTAGGCRNFPATFWIN 394

  Fly   376 PQLLISVQDEQD-----------LVIALNQ-------HTAVEPKVIGFTMYTWDGEY--MLSECL 420
            ||..|.:.:|.|           .::||.|       ....:.:.|||.:|....::  .....|
 Frog   395 PQFKIKLDEEDDDDDFGSEKGCTFLLALMQKDKRKERRFGKDMETIGFAVYEVPSQFHGQSGVHL 459

  Fly   421 QKDFFKNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLE 484
            ::|||..:.|...|: :.|.|.||....|..|.|:::|:|:||..|..|.||.....  :...:|
 Frog   460 KRDFFLQNASRARSEQFINLREVSTRHKLPPGEYIVVPSTFEPNVEGDFVVRFFSEN--KHGSVE 522

  Fly   485 TQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLP--NDY 547
            ....:..|..|....::||...|        ::.::.|||..:..|:..||..:|...:.  .|.
 Frog   523 MDDPLSADLPPEEVLSEAEIDQG--------FKNLFKQLAGADNEISATELQSILNKIMSKHKDL 579

  Fly   548 IKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALC 612
            .....:::.||.::.|.|:.|:|::...:|......:|::..||:.:..:|:|.:.|..:|.|:.
 Frog   580 RTSGFSLESCRSMVNLMDKDGNGKLGLVEFNVLWNKIKNYLTVFRKFDMDKSGSMSAYEMRLAVE 644

  Fly   613 DIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWIK 676
            ..||:|:..:...:|.||...|..:....|...:|.|.|.|..|...:..:..||...:..|::
 Frog   645 SAGFKLTNSLHQLIITRYSEPDMAVNFDSFTCCLIRLETMFRFFQGMDTEKKGVIHFDIFKWLQ 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	101/335 (30%)
		Calpain_III	346..483	CDD:238132	47/158 (30%)
		EFh_PEF	515..680	CDD:355382	39/164 (24%)
		EF-hand motif	515..543	CDD:320054	7/27 (26%)
		EF-hand motif	556..585	CDD:320054	7/28 (25%)
		EF-hand motif	586..615	CDD:320054	7/28 (25%)
		EF-hand motif	622..650	CDD:320054	6/27 (22%)
		EF-hand motif	652..680	CDD:320054	5/25 (20%)
capn1	NP_001013632.1	Peptidase_C2	56..352	CDD:459889	96/323 (30%)
		Calpain_III	364..523	CDD:238132	48/165 (29%)
		EFh_PEF_CAPN1	545..713	CDD:320073	40/172 (23%)
		EF-hand motif	545..573	CDD:320073	8/35 (23%)
		EF-hand motif	588..617	CDD:320073	7/28 (25%)
		EF-hand motif	618..648	CDD:320073	7/29 (24%)
		EF-hand motif	654..682	CDD:320073	6/27 (22%)
		EF-hand motif	684..713	CDD:320073	5/25 (20%)