DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and capn1

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001013632.1	Gene:	capn1 / 541455	XenbaseID:	XB-GENE-990196	Length:	713	Species:	Xenopus tropicalis

Alignment Length:	714	Identity:	196/714 - (27%)
Similarity:	330/714 - (46%)	Gaps:	81/714 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASKYERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPP-----FTFQWKRIMDLADSGSGAVAAN 60
            :...|:|||.:|.....|::|..||....|:.:.:..|     :..:|.|...|..:
Frog    38 LGQDYDRILHECLQNRTLFKDDTFPPSAYSLGFKELGPNSSKTYGVKWVRPSQLVSN-------- 94

  Fly    61 SSAAPVFLNESA-EFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWW 123
                |.|:.:.| ..|:..|.:||.||::.:..|:....:.:||||..|:....: |||.|:||.
Frog    95 ----PQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTILHRVVPHGQSFQDNYAGVFHFQLWQ 155

  Fly   124 CGEWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGG 188
            .||||:|::||.||..:|:|.|:...:.|.||:||||||.||.:|.||||..|:.|:|..|..||
Frog   156 FGEWVDVVIDDYLPVKDGKLVFVHSASGNEFWSALLEKAYAKANGCYEALSGGSTSEGFEDFTGG 220

  Fly   189 V-----VRQMP--ILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRL 246
            |     :::.|  :.|..::......|:..:..:|...|..|...||         ::....|.:
Frog   221 VTEWYEMKKAPKDLFSIIMKAVERGSLMGCSIDITSATDMEAVTFKK---------LVKGHAYSV 276

  Fly   247 SSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEF 311
            :...:: ...|.|.:|:.:::     |:|| ..:.|.||..|..|..|...:...|..::..|||
Frog   277 TGAKEI-NFRGRSQKLIRMRN-----PWGE-VEWTGAWSDNSSEWNSVDAADSQDLRIKMEDGEF 334

  Fly   312 WLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHIN 375
            |::|.||:..||.:|:..|..:.....:..|     |...:..|.|::|.|||||||. .:|.||
Frog   335 WMAFEDFLREFSRLEICNLTPDALTARKYRK-----WNTTVFNGNWRKGSTAGGCRNFPATFWIN 394

  Fly   376 PQLLISVQDEQD-----------LVIALNQ-------HTAVEPKVIGFTMYTWDGEY--MLSECL 420
            ||..|.:.:|.|           .::||.|       ....:.:.|||.:|....::  .....|
Frog   395 PQFKIKLDEEDDDDDFGSEKGCTFLLALMQKDKRKERRFGKDMETIGFAVYEVPSQFHGQSGVHL 459

  Fly   421 QKDFFKNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLE 484
            ::|||..:.|...|: :.|.|.||....|..|.|:::|:|:||..|..|.||.....  :...:|
Frog   460 KRDFFLQNASRARSEQFINLREVSTRHKLPPGEYIVVPSTFEPNVEGDFVVRFFSEN--KHGSVE 522

  Fly   485 TQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLP--NDY 547
            ....:..|..|....::||...|        ::.::.|||..:..|:..||..:|...:.  .|.
Frog   523 MDDPLSADLPPEEVLSEAEIDQG--------FKNLFKQLAGADNEISATELQSILNKIMSKHKDL 579

  Fly   548 IKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALC 612
            .....:::.||.::.|.|:.|:|::...:|......:|::..||:.:..:|:|.:.|..:|.|:.
Frog   580 RTSGFSLESCRSMVNLMDKDGNGKLGLVEFNVLWNKIKNYLTVFRKFDMDKSGSMSAYEMRLAVE 644

  Fly   613 DIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWIK 676
            ..||:|:..:...:|.||...|..:....|...:|.|.|.|..|...:..:..||...:..|::
Frog   645 SAGFKLTNSLHQLIITRYSEPDMAVNFDSFTCCLIRLETMFRFFQGMDTEKKGVIHFDIFKWLQ 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	101/335 (30%)
		Calpain_III	346..483	CDD:238132	47/158 (30%)
		FRQ1	<567..648	CDD:227455	19/80 (24%)
capn1	NP_001013632.1	Peptidase_C2	56..352	CDD:366222	96/323 (30%)
		Calpain_III	373..518	CDD:366446	46/146 (32%)
		EFh_PEF_CAPN1	545..713	CDD:320073	40/172 (23%)
		EF-hand motif	545..573	CDD:320073	8/35 (23%)
		EF-hand motif	588..617	CDD:320073	7/28 (25%)
		EF-hand motif	618..648	CDD:320073	7/29 (24%)
		EF-hand motif	654..682	CDD:320073	6/27 (22%)
		EF-hand motif	684..713	CDD:320073	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010