Protein Alignment CalpC and Capn15

DIOPT Version :10

• Sequence 1: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001334263.1
• Gene: Capn15 / 50817
• MGIID: 1355075
• Length: 1196
• Species: Mus musculus
• Alignment Length: 674
• Identity: 155/674 - (22%)
• Similarity: 247/674 - (36%)
• Gaps: 187/674 - (27%)

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPF-------TFQWKRIMDLADSGSGAVAANSS 62
            :|.|::.||..:|.:.|..||...:||.:    |.       ..||.|..::          |.|
Mouse   550 WENIVAFCRENSVNFVDDSFPPGPASVGF----PVGDSVQQRVKQWLRPHEI----------NCS 600

  Fly    63 AAPVFLNESAEF---------DVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAHGVFR 118
               ||.:....:         |::.|.:|:.|.:|.|.:|:...:|..||: ..::|. |.|.::
Mouse   601 ---VFRDHGTPWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVM-VTRSLC-AEGAYQ 660

  Fly   119 FRLWWCGEWVEVLVDDRLPTIN-GRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGL 182
            .||...|.|..|||||.||... |.|.|.|.|... .|.||:|||:|||||||.||:.|...:||
Mouse   661 VRLCKDGTWTTVLVDDMLPCDEAGFLLFSQAQRKQ-LWVALIEKALAKLHGSYFALQAGRAIEGL 724

  Fly   183 TDLLGGVVRQMPILSDNIRPQTLKELLTTTCI-VTCLADKSA----------------TVAKKNL 230
            ..|.|.....:.:...:..|:  :|.:.|..| ...|:.|.|                ..|.::|
Mouse   725 ATLTGAPCESLALQVSSTNPR--EEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDAAYESL 787

  Fly   231 AERMPNGILVNVNYRLSSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVS 295
            ..|        ..:..|.|| |:.:.|.  :|:.|::     |:| :..:.|.||.....|.
Mouse   788 GLR--------PRHAYSVLD-VRDVQGS--RLLRLRN-----PWG-RFSWNGSWSDEWPHWP--- 832

  Fly   296 QVERARLIRQLGP-----GEFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQG 355
                ..|..:|.|     |.||:.:.||:..|.::::..:.::              |:....||
Mouse   833 ----GHLRAELMPHGSSEGVFWMEYSDFIRYFDSVDICKVHSD--------------WQEARVQG 879

  Fly   356 QWKR------GVTAGGCRNHESFHINPQLLISVQDEQDLVIALNQH-----TAVEPKVIGFTMYT 409
            .:..      ||||                ::|.:...|..||.|.     .:|:..::...:..
Mouse   880 CFPSTAGGPVGVTA----------------LTVLERASLEFALFQEGSRRSDSVDSHLLDLCILV 928

  Fly   410 W------DGEYMLSECLQKDFFKNHVSYLNSDYGNTRHVSYHTHLEAGHYVLI--------PTTY 460
            :      .|...|...|           .:|.....:.|:....||.|.|.::        |...
Mouse   929 FRATFGTGGRLSLGRLL-----------AHSKRAVKKFVNCDVMLEPGEYAVVCCAFNHWNPAPP 982

  Fly   461 EPAEEAHFTVRILGTGSFRLSCLETQ---TMILLDPFPALKSTDAERCGGPK------------- 509
            .|..:.....::..|.||..|  |.|   |..||.|.....:..:...|.|:
Mouse   983 GPPAQGKGPSQMRPTPSFPTS--EPQSPPTGKLLAPLSTPPTASSPSAGVPRGAPEPPGHVLAVY 1045

  Fly   510 VKSVCQYEPVYMQ---LAD------ENKTINCFELHELLEACLPNDYIKGCANIDICRQVIALQD 565
            ...:...|||..|   |||      |::.    |.||..|.........|.|.:     ::.:::
Mouse  1046 SSRLVMVEPVEAQPTTLADAIILLTESRG----ERHEGREGMTCYYLTHGWAGL-----IVVVEN 1101

  Fly   566 RSGSGRITFQQFKTFMVNLKSWQG 589
            |.....:..|...|...|:.|.:|
Mouse  1102 RHPKSYLHVQCDCTDSFNVVSTRG 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	98/360 (27%)
		Calpain_III	346..483	CDD:238132	28/161 (17%)
		EFh_PEF	515..680	CDD:355382	20/84 (24%)
		EF-hand motif	515..543	CDD:320054	12/36 (33%)
		EF-hand motif	556..585	CDD:320054	4/28 (14%)
		EF-hand motif	586..615	CDD:320054	2/4 (50%)
		EF-hand motif	622..650	CDD:320054
		EF-hand motif	652..680	CDD:320054
Capn15	NP_001334263.1	ZnF_RBZ	71..95	CDD:197784
		RanBP2-type Zn finger	73..92	CDD:275376
		ZnF_RBZ	113..135	CDD:197784
		RanBP2-type Zn finger	114..133	CDD:275376
		ZnF_RBZ	219..241	CDD:197784
		RanBP2-type Zn finger	219..238	CDD:275376
		ZnF_RBZ	420..442	CDD:197784
		RanBP2-type Zn finger	420..439	CDD:275376
		RanBP2-type Zn finger	457..472	CDD:275375
		ZnF_RBZ	490..514	CDD:197784
		RanBP2-type Zn finger	492..511	CDD:275376
		CysPc	552..867	CDD:238004	98/360 (27%)