DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and capn13

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001008025.1	Gene:	capn13 / 493387	XenbaseID:	XB-GENE-6045506	Length:	763	Species:	Xenopus tropicalis

Alignment Length:	777	Identity:	198/777 - (25%)
Similarity:	328/777 - (42%)	Gaps:	149/777 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPP---FTFQWKRIMDLADSGSGAVAANSSAAPV 66
            ::.|...|.|:..|:||..|||..||:.....|.   .:.:|:|..::           .|.|.:
Frog    34 FDSIRESCYSRRQLFEDETFPASVSSIGQKLLPKDQLLSIKWERPKEI-----------QSDARL 87

  Fly    67 FLNESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEV 130
            .::.::.||:|.|.:||.|:::.:|.|:..:.....|:|.||.....: |.|.||.|..||||:|
Frog    88 LVDGASIFDMVQGYLGDCWVLAAVGALTLHQKFLDIVIPKDQEFNYKYAGAFHFRFWQFGEWVDV 152

  Fly   131 LVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPI 195
            ::||||||:||:...:.|::.|.||..|||||.|||.|||:.|.:|..|:.|.|..|||:.:..:
Frog   153 VIDDRLPTLNGKYLSVHPRSDNEFWPTLLEKAYAKLRGSYQNLHWGYISEALVDFSGGVLVEFDL 217

  Fly   196 LSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMG--D 258
            ...   ||.|::::........|...:....|::....:.||::....|.::...:|:...|  |
Frog   218 TKP---PQDLRDIVIAAAKSGSLMGSNTPGGKQSGNPELQNGLVQGHAYTVTDATQVEYKNGTED 279

  Fly   259 SVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFCDFVEIFS 323
            .|::        ..|:| |..:.|.||..:..|:||....|.:|..|...||||:|..||::.||
Frog   280 LVRV--------WNPWG-KGEWNGRWSDNAPQWDRVRADVRQKLNVQKNDGEFWMSCQDFLQNFS 335

  Fly   324 TMEV-----VYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNHESFHINPQLLISVQ 383
            ...:     .|.|.:.....         |:...:..:|.||.||.||.:.|....|||.:|||.
Frog   336 CASICNHTPAYFDFDNPKRT---------WQTLTYFSRWVRGSTAAGCSSKEDLWRNPQFVISVS 391

  Fly   384 DEQ------DLVIALNQHTAVEPKV------IGFTMYTWDGEYMLSECLQKDFFKNHVSYLNSDY 436
            |.:      ::.:||.|....|.|.      |||.:.......:.....|....|..:..:|::.
Frog   392 DSEGMKRGYNVTVALMQSLENEHKYSQRWMGIGFALCRVASMGVKGISQQNYSAKQAMDVINTEI 456

  Fly   437 GNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMILLDPFPALKSTD 501
            ..:|.|:.......|.||:||.|....:|:.|.:||.         |:|:.   :|.|...|:..
Frog   457 QISREVTRSFMAPPGTYVVIPFTESKGQESEFLLRIF---------LKTKE---IDKFQDTKTVP 509

  Fly   502 AE-------RCGG--------------------------------PKVKSVCQ------------ 515
            .|       ..||                                |:.:|..|
Frog   510 REGNQTFYPSNGGSRYQDPKPKPRDDNQPMYPNETRARNQSSSSLPREESPYQYGSDGGLSDFSS 574

  Fly   516 --------------------YEPVYMQLADENKTINCFELHELLEACLPNDYI----KGCANIDI 556
                                ||.|:.:..:::..:...:|..||...:..|..    :|...:|.
Frog   575 SLSMNSQIPKAVLKKYQDDNYEMVFTRYCNKSSELYAEQLQRLLNEVIIKDQTFAGGRGDFTLDA 639

  Fly   557 CRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALCDIGFQLSTD 621
            ||.::.|.|.:.:||::.|:|......|...:.:|:.....:.|.:.|..|:.|:...|..:|..
Frog   640 CRGILMLMDLNANGRLSLQEFGRLWKRLNMCKDMFRSIDGNQTGFIDASGLKKAVQLAGLPISNA 704

  Fly   622 IMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQF-HLKNYGQVNVIEVHL--HDWIKSILS 680
            ::|.::.||......|..:|||..:|.|.|....| :|...|:    .|:|  .:|::.|:|
Frog   705 LINVMVLRYANSSEKLSFADFVCCMIRLETVTKVFKNLSKDGR----GVYLSGEEWMQIIMS 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	103/332 (31%)
		Calpain_III	346..483	CDD:238132	39/148 (26%)
		FRQ1	<567..648	CDD:227455	19/80 (24%)
capn13	NP_001008025.1	Peptidase_C2	48..341	CDD:366222	99/315 (31%)
		Calpain_III	364..497	CDD:366446	39/141 (28%)
		EFh_PEF_CAPN13_14	595..763	CDD:320070	43/172 (25%)
		EF-hand motif	595..622	CDD:320070	6/26 (23%)
		EF-hand motif	639..668	CDD:320070	8/28 (29%)
		EF-hand motif	669..699	CDD:320070	5/29 (17%)
		EF-hand motif	705..733	CDD:320070	8/27 (30%)
		EF-hand motif	735..763	CDD:320070	8/32 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020