Protein Alignment CalpC and capn3a

DIOPT Version :10

• Sequence 1: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: XP_017207114.1
• Gene: capn3a / 447832
• ZFINID: ZDB-GENE-040912-97
• Length: 733
• Species: Danio rerio
• Alignment Length: 742
• Identity: 207/742 - (27%)
• Similarity: 353/742 - (47%)
• Gaps: 120/742 - (16%)

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQ-----TPPFTFQWKRIMDLADSGSGAVAANSSAA 64
            |..:..:...|..|:||..|||...|:.|.:     .......|||..::.|:
Zfish    37 YTLLKQEYLQKKTLFEDETFPATVDSLGYKELGHKSNKVKNIVWKRPKEICDN------------ 89

  Fly    65 PVFL-NESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEW 127
            |.|: ..::..|:..|.:||.||::.:..|:....|.|||:|.:|:.:..: |:|.|:.|..|:|
Zfish    90 PQFIVGGASRTDICQGDLGDCWLLAAIACLTLNDKLLYRVIPQEQSFSEQYAGIFHFQFWRYGDW 154

  Fly   128 VEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGV--- 189
            |:|:||||:||.|.:|.|.:....|.||:||||||.|||||||||||.|..::|:.|..|||
Zfish   155 VDVVVDDRIPTFNNQLVFTKSAERNEFWSALLEKAYAKLHGSYEALKGGNTAEGMEDFTGGVTEF 219

  Fly   190 --VRQMPILSDNIRPQTLKEL-------LTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYR 245
              :::.|           |||       |....::.|..|   ::.......|...|::....|.
Zfish   220 YEMKEAP-----------KELYKIMQKALERGSLMGCSID---SLVPARFETRTATGLVKGHAYS 270

  Fly   246 LSSLDKVKTLM--GDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQ-LG 307
            ::::::.|...  ...|:||.|::     |:|: ..:.|.||..||.||.:|:.|:.:|.:| ..
Zfish   271 VTAVEECKQSQQKESRVRLVRLRN-----PWGQ-VEWNGPWSDNSKEWESLSKAEKEKLQQQNAE 329

  Fly   308 PGEFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ES 371
            .||||:||.||.:.::.:|:..|..:...|:::.|     |.:.:::|:|.||.:||||||: ::
Zfish   330 DGEFWMSFEDFKKNYTKIEICNLTPDALEDDKLHK-----WTVSVNEGRWVRGCSAGGCRNYPDT 389

  Fly   372 FHINPQLLISVQDEQD----------LVIALNQHTAVEPK-------VIGFTMYTWDGE-YMLSE 418
            |..|||..:.:.:|.|          .|:||.|....:.:       .|||::|....| :...:
Zfish   390 FWTNPQYRLRLLEEDDDPEDDEVACTFVVALMQKNRRKERKLGANLLTIGFSIYEVPKEMHGNKQ 454

  Fly   419 CLQKDFFKNHVSYLNS-DYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSC 482
            .:||:||.:..:...| .|.|.|.|:....|..|.||:||::|||.:|..|.:|:.  ...|.:.
Zfish   455 HMQKEFFMSTTAKARSRAYINLREVTQRFRLSPGEYVIIPSSYEPHQEGEFILRVF--SEKRNTS 517

  Fly   483 LETQTMILLD-PFPALKSTDAERCGGPKVKSVCQYEPVYMQLADE------------NKTINCFE 534
            .|.:..|..| |.|:..||      |.:.:...|:..::..:|.:            |..::..|
Zfish   518 EEIENRIEADHPVPSPAST------GEESEEDQQFLSIFQHIAGDVSTGEAVSAWGSNMEVSANE 576

  Fly   535 LHELLEACL-------PNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFK 592
            |.::|...:       ...:.:.|     ||.:|||.|..|:||:..|:|:.....:|.||.:||
Zfish   577 LKDVLNKVVSKHKDIHTESFSREC-----CRSMIALMDMDGTGRLNLQEFRQLWNKIKQWQEIFK 636

  Fly   593 MYTKEKAGILRAERLRDAL--------CDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHL 649
            .|..:....:.:..:|:|:        |..||:|:..:.:.:..||..:...:....|:|.::.|
Zfish   637 RYDFDHNDTISSYEMRNAINDAVTCLVCHSGFRLNNQLYDIITMRYANESMNVDFESFISCLVRL 701

  Fly   650 TTAFNQFHLKNYGQVNVIEVHLHDWIK 676
            ...|..|...:......|.:.:.:|::
Zfish   702 EGMFRAFQAFDQCGDGSIRLSVLEWLQ 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	108/343 (31%)
		Calpain_III	346..483	CDD:238132	48/156 (31%)
		EFh_PEF	515..680	CDD:355382	39/189 (21%)
		EF-hand motif	515..543	CDD:320054	6/39 (15%)
		EF-hand motif	556..585	CDD:320054	11/28 (39%)
		EF-hand motif	586..615	CDD:320054	8/36 (22%)
		EF-hand motif	622..650	CDD:320054	4/27 (15%)
		EF-hand motif	652..680	CDD:320054	4/25 (16%)
capn3a	XP_017207114.1	Peptidase_C2	51..351	CDD:459889	106/331 (32%)
		Calpain_III	371..510	CDD:460050	46/138 (33%)
		EFh_PEF	545..733	CDD:355382	39/189 (21%)
		EF-hand motif	545..585	CDD:320054	6/39 (15%)
		EF-hand motif	600..629	CDD:320054	12/33 (36%)
		EF-hand motif	630..667	CDD:320054	8/36 (22%)
		EF-hand motif	674..702	CDD:320054	4/27 (15%)
		EF-hand motif	704..732	CDD:320054	4/25 (16%)