DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and CAPN14

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001138594.1	Gene:	CAPN14 / 440854	HGNCID:	16664	Length:	684	Species:	Homo sapiens

Alignment Length:	686	Identity:	194/686 - (28%)
Similarity:	309/686 - (45%)	Gaps:	107/686 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSV----FYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAP 65
            :|.:|::|.....|:||..|||..||:    ...:.|| ..||||..:|           .|...
Human    30 FEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPP-RLQWKRPPEL-----------HSNPQ 82

  Fly    66 VFLNESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVE 129
            .:..::...|:..|.:||.|.::.|..|:..:::..||||.:|:....: |:|||..|..|.||.
Human    83 FYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWVP 147

  Fly   130 VLVDDRLPTIN--GRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQ 192
            |::||||| :|  |:|.|:.....|.||.||||||.|||.||||.|:.|..|:.|.|..|||...
Human   148 VVIDDRLP-VNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGGVTMT 211

  Fly   193 MPILS--DNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTL 255
            :.:..  .|:. ..|.|......::.|.......:        :.||::....|.|:.:.|| |.
Human   212 INLAEAHGNLW-DILIEATYNRTLIGCQTHSGEKI--------LENGLVEGHAYTLTGIRKV-TC 266

  Fly   256 MGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFCDFVE 320
            ......||.|::     |:| |..:.||||..|..||.:|..|:..|:|:...||||::..||..
Human   267 KHRPEYLVKLRN-----PWG-KVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQDFKT 325

  Fly   321 IFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRN--HESFHINPQLLISVQ 383
            .|..:.:..|.....:.|...|     |...|.:|:|::..||||.|.  .::|..|||.|:||.
Human   326 HFVLLVICKLTPGLLSQEAAQK-----WTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLLSVW 385

  Fly   384 DEQD---------LVIALNQ---HTAVEPK---VIGFTMYTWDGEYMLSECLQKDFFKNHVSYLN 433
            ..::         ::::|.|   |...:.|   .|||.:|..:..:.....|..:||:.:.....
Human   386 RPEEGRRSLRPCSVLVSLLQKPRHRCRKRKPLLAIGFYLYRMNKYHDDQRRLPPEFFQRNTPLSQ 450

  Fly   434 SD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRI---------LGTGSFRLSCLETQTM 488
            .| :...:.||....||.|.|:::|...|..:::.|.:|:         :|:.|..:...|.:
Human   451 PDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKHIFYEIGSNSGVVFSKEIE-- 513

  Fly   489 ILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLPNDYIKGCA- 552
                       ...||           .:..:.:..:::..||..:|..||.....:..  |..
Human   514 -----------DQNER-----------QDEFFTKFFEKHPEINAVQLQNLLNQMTWSSL--GSRQ 554

  Fly   553 ---NIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALCDI 614
               :::.|:.::||.|.:.||.::.|:|:.....||..|.||....: .:|.|..|:|..|:.:.
Human   555 PFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDR-GSGYLNWEQLHAAMREA 618

  Fly   615 GFQLSTDIMNCLIQRYIRKDGTLRLS-DFVSAVIHL 649
            |..||.|:...::.||    |..||. |||| .|||
Human   619 GIMLSDDVCQLMLIRY----GGPRLQMDFVS-FIHL 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	107/330 (32%)
		Calpain_III	346..483	CDD:238132	40/163 (25%)
		FRQ1	<567..648	CDD:227455	27/81 (33%)
CAPN14	NP_001138594.1	Peptidase_C2	44..334	CDD:279042	104/318 (33%)
		Domain III	337..503		41/170 (24%)
		Calpain_III	348..496	CDD:279416	38/147 (26%)
		Linker	504..517		2/25 (8%)
		Domain IV	518..683		41/151 (27%)
		EFh	562..616	CDD:298682	18/54 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920