Protein Alignment CalpC and Capn11

DIOPT Version :10

• Sequence 1: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001002806.2
• Gene: Capn11 / 408218
• RGDID: 1302946
• Length: 715
• Species: Rattus norvegicus
• Alignment Length: 723
• Identity: 212/723 - (29%)
• Similarity: 352/723 - (48%)
• Gaps: 107/723 - (14%)

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPP-----FTFQWKRIMDLADSGSGAVAANSSAA 64
            :|.:.:.|.....|:|||.|||...|:.:.:..|     ....|:|..|:..:
  Rat    42 FEDLRASCLKMGELFEDPFFPAEPQSIGFKELGPKSQEVHNVYWQRPKDIIHN------------ 94

  Fly    65 PVFL-NESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEW 127
            |.|: |:.:..|:..|.:||.||::.:|.|::...|.:||||..|:....: |:|.|:||..|.|
  Rat    95 PQFITNDFSPTDICQGILGDCWLLAAIGSLTTSPKLLFRVVPRSQSFKKNYAGIFHFQLWQFGHW 159

  Fly   128 VEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVR- 191
            :.|:|||||||.|.:|.|:.......||.||||||.|||:||||||..|:..:||.|..||:.:
  Rat   160 LNVVVDDRLPTKNNKLVFVHASHRQEFWGALLEKAYAKLNGSYEALTGGSTMEGLEDFTGGMAQC 224

  Fly   192 ---QMPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVN-YRLSSL--- 249
               |.|       |..|..||......:.|...|......:..|:|.:.:||..: |.::.|
  Rat   225 IRLQNP-------PHNLLRLLRKALEKSSLMGCSIEATNSDDVEKMAHNMLVKGHAYAITGLQDV 282

  Fly   250 ---DKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEF 311
               ||::||:  .:|          .|:| :..:.|.||..:|.||.|....:.:|:.:...|||
  Rat   283 YYRDKLETLI--RIQ----------NPWG-RIEWNGAWSDKAKEWEEVMPEVQMQLLHKKEDGEF 334

  Fly   312 WLSFCDFVEIFSTMEVVYL--DTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFH 373
            |:|:.||:..|:.:|:..|  |..:|.|.:..      |.....:|.|:||.|||||||: |:|.
  Rat   335 WMSYEDFMSNFTLLEICNLTPDALSSWDYKSC------WHTTFFEGSWRRGSTAGGCRNYPETFW 393

  Fly   374 INPQLLISVQDEQD-------------LVIALNQ----HTAVEPKV--IGFTMYTWDGEYM-LSE 418
            .|||..||:.:..|             .::||.|    |....|::  |||.:::...|:. |.:
  Rat   394 SNPQFRISLPETDDPEDSSDKSEMVCTCLVALMQKNWRHAREGPQLLTIGFVVFSVPKEFQNLQD 458

  Fly   419 C-LQKDFFKNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLS 481
            . |:||||..:..:..|: :.|||.|:.|..|..|.||:||:|:||.::|.|.:|:     |...
  Rat   459 IHLKKDFFMKYRDHGFSEIFTNTREVNSHLRLPPGEYVIIPSTFEPHKDADFLLRV-----FTEK 518

  Fly   482 CLETQTMILLDPFPALKS------TDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELL- 539
            ..||.   |||....|:.      |||:.    ...||..:|    .||:.:..::.::|.:||
  Rat   519 HSETW---LLDEVNMLEQLQEETITDADL----DQNSVELFE----TLANRDSQVDMYDLQKLLN 572

  Fly   540 --EACLPNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGIL 602
              .:...:...|| .::|:||:::.|.|:..||::...:|......:|.|..:||...::::|.|
  Rat   573 KMSSKFKSFKSKG-FSLDVCRRMVNLMDKDDSGKLGLHEFHILWKKIKKWMEIFKECDQDRSGNL 636

  Fly   603 RAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVI 667
            .:..:|.|:...|.:::..:...::.||...:..:...:|::..:.|...|..|...:..:...|
  Rat   637 NSYEMRLAIEKAGIRMNNRVTEVVVARYADANMIVDFDNFINCFLRLKAMFAFFLSMDTKKTGSI 701

  Fly   668 EVHLHDWI 675
            .::::.|:
  Rat   702 CLNINQWL 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	109/339 (32%)
		Calpain_III	346..483	CDD:238132	54/159 (34%)
		EFh_PEF	515..680	CDD:355382	33/164 (20%)
		EF-hand motif	515..543	CDD:320054	6/30 (20%)
		EF-hand motif	556..585	CDD:320054	7/28 (25%)
		EF-hand motif	586..615	CDD:320054	7/28 (25%)
		EF-hand motif	622..650	CDD:320054	3/27 (11%)
		EF-hand motif	652..680	CDD:320054	4/24 (17%)
Capn11	NP_001002806.2	Peptidase_C2	56..352	CDD:459889	107/327 (33%)
		Calpain_III	367..525	CDD:238132	56/165 (34%)
		Linker. /evidence=ECO:0000250|UniProtKB:Q9UMQ6	528..543		3/14 (21%)
		Domain IV. /evidence=ECO:0000250|UniProtKB:Q9UMQ6	544..714		35/175 (20%)
		EFh_PEF	547..715	CDD:355382	35/168 (21%)
		EF-hand motif	547..575	CDD:320054	8/31 (26%)
		EF-hand motif	590..619	CDD:320054	7/28 (25%)
		EF-hand motif	620..649	CDD:320054	7/28 (25%)
		EF-hand motif	656..684	CDD:320054	3/27 (11%)
		EF-hand motif	686..714	CDD:320054	4/24 (17%)