DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and Capn11

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001002806.2	Gene:	Capn11 / 408218	RGDID:	1302946	Length:	715	Species:	Rattus norvegicus

Alignment Length:	727	Identity:	213/727 - (29%)
Similarity:	351/727 - (48%)	Gaps:	115/727 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPP-----FTFQWKRIMDLADSGSGAVAANSSAA 64
            :|.:.:.|.....|:|||.|||...|:.:.:..|     ....|:|..|:..:
  Rat    42 FEDLRASCLKMGELFEDPFFPAEPQSIGFKELGPKSQEVHNVYWQRPKDIIHN------------ 94

  Fly    65 PVFL-NESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEW 127
            |.|: |:.:..|:..|.:||.||::.:|.|::...|.:||||..|:....: |:|.|:||..|.|
  Rat    95 PQFITNDFSPTDICQGILGDCWLLAAIGSLTTSPKLLFRVVPRSQSFKKNYAGIFHFQLWQFGHW 159

  Fly   128 VEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVR- 191
            :.|:|||||||.|.:|.|:.......||.||||||.|||:||||||..|:..:||.|..||:.:
  Rat   160 LNVVVDDRLPTKNNKLVFVHASHRQEFWGALLEKAYAKLNGSYEALTGGSTMEGLEDFTGGMAQC 224

  Fly   192 ---QMPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILV-----------NV 242
               |.|       |..|..||......:.|...|......:..|:|.:.:||           :|
  Rat   225 IRLQNP-------PHNLLRLLRKALEKSSLMGCSIEATNSDDVEKMAHNMLVKGHAYAITGLQDV 282

  Fly   243 NYRLSSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLG 307
            .||    ||::||:  .:|          .|:| :..:.|.||..:|.||.|....:.:|:.:..
  Rat   283 YYR----DKLETLI--RIQ----------NPWG-RIEWNGAWSDKAKEWEEVMPEVQMQLLHKKE 330

  Fly   308 PGEFWLSFCDFVEIFSTMEVVYL--DTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH- 369
            .||||:|:.||:..|:.:|:..|  |..:|.|.:..      |.....:|.|:||.|||||||:
  Rat   331 DGEFWMSYEDFMSNFTLLEICNLTPDALSSWDYKSC------WHTTFFEGSWRRGSTAGGCRNYP 389

  Fly   370 ESFHINPQLLISVQDEQD-------------LVIALNQ----HTAVEPKV--IGFTMYTWDGEYM 415
            |:|..|||..||:.:..|             .::||.|    |....|::  |||.:::...|:.
  Rat   390 ETFWSNPQFRISLPETDDPEDSSDKSEMVCTCLVALMQKNWRHAREGPQLLTIGFVVFSVPKEFQ 454

  Fly   416 -LSEC-LQKDFFKNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGS 477
             |.:. |:||||..:..:..|: :.|||.|:.|..|..|.||:||:|:||.::|.|.:|:
  Rat   455 NLQDIHLKKDFFMKYRDHGFSEIFTNTREVNSHLRLPPGEYVIIPSTFEPHKDADFLLRV----- 514

  Fly   478 FRLSCLETQTMILLDPFPALKS------TDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELH 536
            |.....||.   |||....|:.      |||:.    ...||..:|    .||:.:..::.::|.
  Rat   515 FTEKHSETW---LLDEVNMLEQLQEETITDADL----DQNSVELFE----TLANRDSQVDMYDLQ 568

  Fly   537 ELL---EACLPNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEK 598
            :||   .:...:...|| .::|:||:::.|.|:..||::...:|......:|.|..:||...:::
  Rat   569 KLLNKMSSKFKSFKSKG-FSLDVCRRMVNLMDKDDSGKLGLHEFHILWKKIKKWMEIFKECDQDR 632

  Fly   599 AGILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQ 663
            :|.|.:..:|.|:...|.:::..:...::.||...:..:...:|::..:.|...|..|...:..:
  Rat   633 SGNLNSYEMRLAIEKAGIRMNNRVTEVVVARYADANMIVDFDNFINCFLRLKAMFAFFLSMDTKK 697

  Fly   664 VNVIEVHLHDWI 675
            ...|.::::.|:
  Rat   698 TGSICLNINQWL 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	110/343 (32%)
		Calpain_III	346..483	CDD:238132	54/159 (34%)
		FRQ1	<567..648	CDD:227455	15/80 (19%)
Capn11	NP_001002806.2	Peptidase_C2	56..352	CDD:279042	108/331 (33%)
		Calpain_III	367..520	CDD:279416	54/157 (34%)
		Linker. /evidence=ECO:0000250\|UniProtKB:Q9UMQ6	528..543		3/14 (21%)
		Domain IV. /evidence=ECO:0000250\|UniProtKB:Q9UMQ6	544..714		35/175 (20%)
		EFh	591..641	CDD:238008	13/49 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920